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Oral rehydration salt effervescent tablet and its application

A technology for effervescent tablets and rehydration salts, applied in the field of oral rehydration salts, can solve the problems of non-contained, non-contained, etc., and achieve the effects of reducing production costs, reducing additions, and being easy to carry and transport.

Active Publication Date: 2012-02-01
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcoming is that its prescription does not contain the effervescent agent necessary for effervescent tablets, and it does not belong to the category of effervescent tablets.
However, oral rehydration salts (ORS) effervescent tablets have not yet appeared

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 (made 1000 oral rehydration salt effervescent tablets altogether)

[0046] Sodium chloride 350g

[0047] Potassium chloride 150g

[0048] Anhydrous glucose 2000g

[0049] Citric acid 215.8g

[0050] Sodium bicarbonate 283.2g

[0051] Macrogol 6000 158g

[0052] Flavor 25g

[0053] Preparation method: put the above-mentioned raw materials and excipients at 45°C for blast drying, pass through a 100-mesh sieve respectively, mix them evenly, and quickly place them in an operating room at a certain humidity, and directly compress them into tablets to make 1,000 tablets in total.

[0054] The tablet pressing process was smooth without sticking, the disintegration time of the effervescent tablet was 1 minute, the hardness was 3Kg, the foaming volume was 10ml, and the solution was clear.

Embodiment 2

[0055] Embodiment 2 (made 1000 oral rehydration salt effervescent tablets altogether)

[0056] Sodium chloride 315g

[0057] Potassium chloride 135g

[0058] Anhydrous glucose 1800g

[0059] Citric acid 194.2g

[0060] Sodium carbonate 160.8g

[0061] Macrogol 6000 15g

[0062] Flavor 15g

[0063] Preparation method: same as the preparation method of specific embodiment 1.

[0064] The tablet pressing process was smooth without sticking, the disintegration time of the effervescent tablet was 1 minute and 15 seconds, the hardness was 3Kg, the foaming volume was 9ml, and the solution was clear.

Embodiment 3

[0065] Embodiment 3 (making 1000 oral rehydration salt effervescent tablets altogether)

[0066] Sodium chloride 350g

[0067] Potassium chloride 150g

[0068] Anhydrous glucose 2000g

[0069] Citric acid 215.8g

[0070] Sodium carbonate 178.7g

[0071] Polyethylene glycol 6000 103.5g

[0072] Lactose 600g

[0073] Flavor 35g

[0074] Pigment 35g

[0075] Preparation method: with the preparation method of embodiment 1.

[0076] The tablet pressing process was smooth without sticking, the powder was compressible and had good fluidity, and the pressed tablet was more beautiful. The disintegration time was 1 minute and 45 seconds, the hardness was 4Kg, and the foaming volume was 8ml.

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Abstract

The invention discloses an oral rehydration salt effervescent tablet which mainly contains sodium chloride, postassium chloride, anhydrous dextrose, citric acid, sodium bicarbonate and / or sodium carbonate and water-soluble lubricant. The invention also discloses the application of the oral rehydration salt effervescent tablet. The oral rehydration salt effervescent tablet is convenient to carry and use. The dosages of an acid source and an alkali source in the oral rehydration salt effervescent tablet can reflect the dosage of sodium citrate needed by the prescription for producing oral rehydration salt (ORSII), thereby reducing the addition of the raw material sodium citrate and lowering the production cost effectively.

Description

technical field [0001] The invention relates to oral rehydration salts, in particular to an oral rehydration salt effervescent tablet and application thereof. Background technique [0002] The development of oral rehydration salts (ORS), since 1964 it was found that glucose has the ability to promote the absorption of Na in the gastrointestinal mucosa + It works with water and is widely used clinically to correct dehydration. It has become one of the first-choice medicines for the treatment of diarrhea and dehydration recommended by the World Health Organization (WHO), and was further recommended by the World Health Organization for the treatment of human cholera, viral and other causes of diarrhea, and achieved success , and quickly promoted and applied in more than 90 countries and regions. [0003] A large number of clinical practices have proved that the success rate of ORS in correcting dehydration acidosis is over 95%, the dehydration correction time is mostly within...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K47/12A61K47/02A61K47/34A61K33/14A61P1/12A61P3/00A61K31/7004A61K31/194A61K47/10
Inventor 高申寇有利陈虹丁雪鹰高静范伟丁宝月
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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