Shell-crosslinked polymeric micelles by using metal nanoparticles as crosslinking agent

A technology of metal nanoparticles and polymer glue, which is applied in the direction of drug combination, drug delivery, medical preparations of non-active ingredients, etc., can solve the problem of non-degradability of cross-linked polymer micelles, and meet the stability requirements , the effect of good biocompatibility
CN101756887AInactive Publication Date: 2010-06-30ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2010-06-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a shell-crosslinked polymeric micelles by using metal nanoparticles as a crosslinking agent and a preparation method thereof. The shell-crosslinked polymeric micelles by using metal nanoparticles as a crosslinking agent consist of polymer micelles and the metal nanoparticles coated on the shells of the polymer micelles. The method for preparing the shell-crosslinked polymeric micelles comprises the following steps: performing functionalized modification on the tail end of an amphiphilic polymer so as to form a functional group capable of reacting with the metal nanoparticles; self-assembling the amphiphilic polymer containing the reactive functional group to form polymeric micelles, and positioning the reactive functional group on the shell surfaces of the polymeric micelles; adding the metal nanoparticles and chemically combining the metal nanoparticles with the reactive functional group so as to form the polymeric micelles crosslinked by the metal nanoparticles. The obtained polymeric micelles have excellent biocompatibility, anti-dilution stability and bio-responsibility, and have wide application prospect in gene and medicament delivery, biosensor and other fields.
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Description

technical field

[0001] The invention relates to a compound and a preparation method, in particular to a shell cross-linked polymer micelle with metal nanoparticles as a cross-linking agent and a preparation method. Background technique

[0002] Polymeric micelles have significant advantages as carriers of anticancer drugs [Eur J Pharm Biopharm 1999, 48, 101]. Compared with other means of solubilizing drugs, the advantages of the polymer micelle-based method stem from its several main properties: polymer micelles can dissolve hydrophobic drugs that are poorly soluble in water in their hydrophobic cores; The shell can prevent drugs from being absorbed by RES (reticuloendothelial system) or MPS (monocyte phagocyte system) and prolong their systemic circulation time; in addition, since tumor vessels are looser than normal vessels, their selective permeability is lower, and they promote Factors such as high vascular permeability and lack of lymphatic drainage in tumors allow pol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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