Chewable tablet prepared from berberis

A technology of barberry fruit and chewable tablets, which is applied in the field of medicine, can solve the problems of inability to achieve medicinal purposes and low utilization rate of medicinal active ingredients, and achieve the effects of high yield, fast onset of action, and good application prospects

Inactive Publication Date: 2010-06-30
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But in the prior art, there is no research on the further development and utilization of Berberis fruit, and the existing Berberis fruit has all adopted the form of direct administration, wherein the utilization rate of medicinal active ingredients is low, and the expected medicinal purpose cannot be achieved. In order to develop the medicinal resources of Berberis fruit, there is an urgent need for a way to effectively utilize it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Get 2kg of barberry fruit coarse powder, add 18kg 95% ethanol, 80 ℃ of water-bath reflux extraction three times, each 2 hours, merge three times filtrate, decompression concentration reclaims solvent, concentrates to 7% volume, obtains extract; Add a small amount of water to make The extract was suspended, subjected to AB-8 macroporous adsorption resin column chromatography, eluted with water, and the eluent was discarded; then eluted with 95% ethanol and acetone, the volume ratio of eluent to acetone was 2:1, Collect the eluate, concentrate under reduced pressure to recover the solvent, and concentrate to 2% volume to obtain an extract; dry the obtained extract at 60°C for 24 hours in a vacuum to obtain a dry solid, which is pulverized into powder to obtain total berberis glycosides powder.

[0023] Take 100g of the above-mentioned total glycosides of berbericin powder, 800g of microcrystalline cellulose, 4g of acesulfame-K, add 15g of water into the spray, mix well, se...

Embodiment 2

[0025] Get 2kg of barberry fruit coarse powder, add 18kg 95% ethanol, 80 ℃ of water-bath reflux extraction three times, each 2 hours, merge three times filtrate, decompression concentration reclaims solvent, concentrates to 7% volume, obtains extract; Add a small amount of water to make The extract was suspended, subjected to AB-8 macroporous adsorption resin column chromatography, eluted with water, and the eluent was discarded; then eluted with 95% ethanol and acetone, the volume ratio of eluent to acetone was 2:1, Collect the eluate, concentrate under reduced pressure to recover the solvent, and concentrate to 2% volume to obtain an extract; dry the obtained extract at 60°C for 24 hours in a vacuum to obtain a dry solid, which is pulverized into powder to obtain total berberis glycosides powder.

[0026] Take 100g of the above-mentioned total berbericin powder, 800g of sucrose, 4g of aspartame, spray and add 15g of water, mix evenly, send into granulation machine granules, d...

Embodiment 3

[0028] Get 2kg of barberry fruit coarse powder, add 18kg 95% ethanol, 80 ℃ of water-bath reflux extraction three times, each 2 hours, merge three times filtrate, decompression concentration reclaims solvent, concentrates to 7% volume, obtains extract; Add a small amount of water to make The extract was suspended, subjected to AB-8 macroporous adsorption resin column chromatography, eluted with water, and the eluent was discarded; then eluted with 95% ethanol and acetone, the volume ratio of eluent to acetone was 2:1, Collect the eluate, concentrate under reduced pressure to recover the solvent, and concentrate to 2% volume to obtain an extract; dry the obtained extract at 60°C for 24 hours in a vacuum to obtain a dry solid, which is pulverized into powder to obtain total berberis glycosides powder.

[0029] Take 100g of the above-mentioned total berbericin powder, 800g mannitol, 4g protein sugar, spray and add 15g water, mix evenly, send into the granulation machine granules, d...

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PUM

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Abstract

The invention belongs to the technical field of medicine and discloses a chewable tablet which is prepared by taking total glucoside of berberis as the main material together with auxiliary materials and flavoring agents, the taste of the medicine is improved while the curative effect of the medicine is ensured, and the additives are all edible and harmless to human body. By adopting special purification method to purify the total glucoside of the berberis and normal tablet formation technique, the invention reduces the production cost, improves the yield and is widely applicable in pharmaceutical field. The chewable tablet prepared from berberis has good taste and is convenient to take, quick to be absorbed, quick in effect and high in bioavailability. Therefore, the chewable tablet has a good application prospect.

Description

Technical field: [0001] The invention relates to a chewable tablet with berberberry total glycosides powder as the main raw material and a preparation method thereof, belonging to the technical field of medicine. Background technique: [0002] Berberis is a general term for about 500 species of thorny evergreen or deciduous shrubs belonging to the genus Berberis in the family Berberidaceae. Most are native to the northern temperate zone, especially in Asia. Berberis plants are woody yellow, with 6 yellow flowers and 3 thorns at the base of the petiole; the fruit is red, yellow, blue, purple or black, and contains one to several seeds. The fruit of several types of barberry can be used to make jelly, which has the effects of clearing away heat and dampness, purging fire and detoxifying. For bacillary dysentery, gastroenteritis, paratyphoid fever, dyspepsia, jaundice, liver cirrhosis ascites, urinary tract infection, acute nephritis, tonsillitis, stomatitis, bronchitis; exte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/29A61P1/00A61P1/02A61P1/14A61P1/16A61P11/00A61P11/04A61P13/00A61P13/12A61P17/02A61P27/02A61P27/16A61P31/04A61K131/00
Inventor 秦大伟王利振
Owner QILU UNIV OF TECH
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