Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof

Abstract

The invention relates to an antibacterial heal-promoting gel material used for preparing medical wound dressing and a preparation method thereof. The antibacterial heal-promoting gel material used for preparing the medical wound dressing is characterized in that the antibacterial heal-promoting gel material comprises natural gel agents, chitosan, bioactive materials, soluble silver salt and organic acids, water is added into the ingredients, the water content accounts for 5 to 20 times of the weight sum of the natural gel agents and the chitosan, and then, the antibacterial heal-promoting gelmaterial of any forms can be obtained through cross-linked curing and aftertreatment. The antibacterial heal-promoting gel material is metered according to dry basis, and is prepared form the following ingredients in percentage by weight:57 to 90.9 percent of natural gel agents, 5 to 25 percent of bioactive materials, 2 to 8 percent of chitosan, 0.1 to 2 of soluble silver salt and 2 to 8 percent of organic acids. The antibacterial heal-promoting gel material has good biocompatibility, good antibiotic property, strong tissue regeneration promoting capacity and various forms, and can be easily and conveniently prepared into the medical wound dressing.

Description

technical field [0001] The invention relates to an antibacterial and healing-promoting gel material for preparing medical wound dressings and a preparation method thereof. Background technique [0002] General medical wound dressings are made of gauze or non-woven fabric and cotton combined with drugs, which can protect the wound from mechanical damage and prevent the wound from being infected, but its antibacterial, absorbent, and anti-inflammatory properties are not satisfactory. Chinese Patent No. 200810122438.1 discloses a preparation method of a hydrogel wound dressing. The hydrogel wound dressing synthesized by this method has a high degree of swelling and a strong ability to absorb wound exudate. There are deficiencies in properties and other aspects; Chinese patent 200820055198.3 discloses a band-aid containing chitin. Natural chitosan has certain antibacterial and anti-inflammatory functions, which can improve its medical performance, but the application is single, ...

AI Technical Summary

Problems solved by technology

Chinese patent 200810122438.1 discloses a method for preparing a hydrogel wound dressing. The hydrogel wound dressing synthesized by this method has a high degree of swelling and a strong ability to absorb wound exudate, but its biocompatibility, promotion of tissue regeneration, antibacterial There are deficiencies in safety and other aspects; Chinese patent 200820055198.3 discloses a band-aid containing chitin. Natural chitosan can improve its medical performance because of its antibacterial and anti-inflammatory functions, but it has a single application and high cost without chemical modification. , the ability to absorb wound exudate is low; Chinese patent 200810157267.6 discloses a manufacturing method of antibacterial calcium alginate fiber, which combines natural gel and cationic antibacterial agent for the manufacture of medical dressings, which has good liquid absorption, Biocompatibility, but compared with nano-silver, its antibacterial property is weak, and it is insufficient in promoting cell growth and accelerating wound healing

[0003] In summary, the medical wound dressings prepared by the above methods may have poor biocompatibility, poor antibacterial properties, or poor ability to absorb wound exudate, or have insufficient ability to promote cell growth and wound healing.

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