Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof

The technology of gel material and wound dressing is applied in the field of antibacterial and healing-promoting gel material and preparation thereof, and can solve the problems of poor biocompatibility of medical wound dressing, poor ability to absorb wound exudate, low ability to absorb wound exudate, etc. Achieve the effect of preventing wound effusion, no drug resistance in the antimicrobial spectrum, and easy peeling and replacement

Active Publication Date: 2010-08-04
HENAN SUPER ASIA MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 200810122438.1 discloses a method for preparing a hydrogel wound dressing. The hydrogel wound dressing synthesized by this method has a high degree of swelling and a strong ability to absorb wound exudate, but its biocompatibility, promotion of tissue regeneration, antibacterial There are deficiencies in safety and other aspects; Chinese patent 200820055198.3 discloses a band-aid containing chitin. Natural chitosan can improve its medical performance because of its antibacterial and anti-inflammatory functions, but it has a single application and high cost without chemical modification. , the ability to absorb wound exudate is low;

Method used

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  • Antibacterial heal-promoting gel material used for preparing medical wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 10g of sodium alginate, 2.8g of polymannuronic oligosaccharide, 0.5g of glycerol, add 100mL of deionized water, stir to obtain a uniform viscous liquid; weigh 30mg of silver citrate, dissolve in 10mL of deionized water, add In the aforementioned liquid, stir, and adjust the pH value with triethanolamine to be 8, and place it for about 30 minutes to promote the reduction and precipitation of the nano-silver particles, then disperse in the glue solution until the color of the system is grayed, and then squeeze and filter through a 100-mesh nylon mesh. Glue (A) is obtained. Separately take 0.8 g of chitosan, add 35 mL of 2wt.% lactic acid solution, stir to dissolve, squeeze and filter through a 100-mesh nylon mesh to obtain glue (B). Stir and mix the glue solution (A) and (B) evenly, vacuum and defoaming, then extrude it with an extruder, coat it on a stainless steel belt or on the surface of the fabric, and then immerse it in a 1.1wt.% ferrous sulfate solution It i...

Embodiment 2

[0035] Weigh 2g of konjac powder, 8g of sodium alginate, 2.5g of polymannuronic oligosaccharide, 0.6g of glycerol, add 100mL of deionized water, stir to obtain a uniform viscous liquid; weigh 30mg of silver citrate, deionized with 10mL Dissolved in water, added to the aforementioned liquid, stirred, and adjusted the pH value to 8 with triethanolamine, left for about 30 minutes, until the color of the system turned gray, squeezed and filtered through a 100-mesh nylon mesh to obtain the glue (A). Another 1 g of chitosan was taken, 50 mL of 2wt.% lactic acid solution was added, stirred to dissolve, and filtered as above to obtain a glue solution (B). The glue (A) and (B) were mixed and stirred evenly, vacuumed and defoamed, then extruded with an extruder, coated on a stainless steel belt or attached to the fabric surface, and then immersed in a 0.9wt.% ferrous sulfate solution It is cross-linked and solidified to form a film, the inorganic salts on the surface are removed by clea...

Embodiment 3

[0037]Weigh 10 g of sodium alginate, 3 g of polymannuronic oligosaccharide, 0.6 g of glycerol, add 100 mL of deionized water, and stir to obtain a uniform viscous liquid. Take 30 mg of silver citrate, dissolve it with 10 mL of deionized water, add it to the aforementioned liquid, stir, and adjust the pH value to 8 with triethanolamine, leave it for about 30 minutes, and the color will turn gray, and squeeze and filter through a 100-mesh nylon mesh to obtain a glue solution (A ). Take another 1.2 g of chitosan, add 50 mL of 2wt.% lactic acid solution, stir to dissolve, and filter as above to obtain colloid (B). The colloids (A) and (B) were mixed and stirred evenly, vacuumed and defoamed, then extruded with an extruder, coated on a stainless steel belt or coated on the surface of a non-woven fabric, and then immersed in 0.8wt.% sulfuric acid It is cross-linked and solidified into a film in an iron solution, and the inorganic salts on the surface are removed by clear water, and...

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Abstract

The invention relates to an antibacterial heal-promoting gel material used for preparing medical wound dressing and a preparation method thereof. The antibacterial heal-promoting gel material used for preparing the medical wound dressing is characterized in that the antibacterial heal-promoting gel material comprises natural gel agents, chitosan, bioactive materials, soluble silver salt and organic acids, water is added into the ingredients, the water content accounts for 5 to 20 times of the weight sum of the natural gel agents and the chitosan, and then, the antibacterial heal-promoting gelmaterial of any forms can be obtained through cross-linked curing and aftertreatment. The antibacterial heal-promoting gel material is metered according to dry basis, and is prepared form the following ingredients in percentage by weight:57 to 90.9 percent of natural gel agents, 5 to 25 percent of bioactive materials, 2 to 8 percent of chitosan, 0.1 to 2 of soluble silver salt and 2 to 8 percent of organic acids. The antibacterial heal-promoting gel material has good biocompatibility, good antibiotic property, strong tissue regeneration promoting capacity and various forms, and can be easily and conveniently prepared into the medical wound dressing.

Description

technical field [0001] The invention relates to an antibacterial and healing-promoting gel material for preparing medical wound dressings and a preparation method thereof. Background technique [0002] General medical wound dressings are made of gauze or non-woven fabric and cotton combined with drugs, which can protect the wound from mechanical damage and prevent the wound from being infected, but its antibacterial, absorbent, and anti-inflammatory properties are not satisfactory. Chinese Patent No. 200810122438.1 discloses a preparation method of a hydrogel wound dressing. The hydrogel wound dressing synthesized by this method has a high degree of swelling and a strong ability to absorb wound exudate. There are deficiencies in properties and other aspects; Chinese patent 200820055198.3 discloses a band-aid containing chitin. Natural chitosan has certain antibacterial and anti-inflammatory functions, which can improve its medical performance, but the application is single, ...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/32A61L15/28A61L15/44
Inventor 赵雪林
Owner HENAN SUPER ASIA MEDICAL EQUIP
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