Preparation method of magnetic fluorescent dual-function nano particle with nuclear shell structure
A core-shell structure, magnetic nanotechnology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of uncontrollable molecular weight and distribution, poor polymer designability, etc., achieving non-toxic or low toxicity, convenient for industrial production, less toxic effect
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[0029] Example 1: Preparation of magnetic nanoparticles modified with ATRP initiator
[0030] 1.91gFe 3 O 4 Magnetic nanoparticles (MNPs) were dispersed in 50 mL of toluene with dewatering by ultrasound (20 minutes) to form a uniformly dispersed suspension;
[0031] Then add 6mL of APTES (0.025mol) and stir for 12 hours at room temperature to obtain APTES-modified magnetic nanoparticles. Wash them with ethanol and dichloromethane for 4-5 times, and separate them with a magnet. The prepared silanized magnetic nanoparticles Used for the modification of the initiator in the next step;
[0032] Disperse the above APTES-modified magnetic nanoparticles in 50 mL of dried dichloromethane (DCM), add 6 mL (0.042 mol) of triethylamine to it, and bathe in ice water until the temperature drops to 0°C. 5mL bromoisobutyryl bromide (0.039mol) was added dropwise to it, and stirred for 12 hours.
[0033] The above-mentioned experimental processes were all carried out under the protection of argon gas....
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[0034] Example 2: Synthesis of fluorescent magnetic nanoparticles using styrene carbazole (VBK) as monomer
[0035] Take monomer (VBK) 200mg (7.1×10 -1 mmol), the initiator obtained in Example 1 10mg (7.1×10 -3 mmol), catalyst (FeCl 3 ·6H 2 O)7mg(2.6×10 -2 mmol), ligand (TDA) 16.5μL (5.2×10 -2 mmol), DMF2mL, Vitamin C 9mg (5.1×10 -2 mmol) in a 5mL ampoule, directly seal the tube in an air atmosphere, and place the sealed ampoule in an oil bath at a constant temperature (90°C) for a predetermined time (4-14h).
[0036] After the reaction is over, take out the sealed tube, immediately cool it with cold water, open the sealed tube, dissolve with tetrahydrofuran, centrifuge for 3 to 4 times, and finally precipitate with methanol to obtain fluorescent and magnetic nanoparticles Fe 3 O 4 @PVBK, the average particle size of the nanoparticles is 130nm.
[0037] Table 1 shows the molecular weight and distribution of the fluorescent polymer grafted on magnetic nanoparticles. It can be seen fro...
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