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Preparation method of magnetic fluorescent dual-function nano particle with nuclear shell structure

A core-shell structure, magnetic nanotechnology, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of uncontrollable molecular weight and distribution, poor polymer designability, etc., achieving non-toxic or low toxicity, convenient for industrial production, less toxic effect

Inactive Publication Date: 2010-08-04
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As we all know, the main disadvantages of conventional free radical polymerization are poor designability, uncontrollable molecular weight and distribution of the polymers obtained; while living polymerization overcomes these shortcomings, it makes it possible to accurately synthesize polymers with various topological structures.
[0005] However, there has not been any report at home and abroad that directly connects compounds with fluorescent groups to the surface of magnetic nanoparticles by living free radical polymerization.

Method used

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  • Preparation method of magnetic fluorescent dual-function nano particle with nuclear shell structure
  • Preparation method of magnetic fluorescent dual-function nano particle with nuclear shell structure
  • Preparation method of magnetic fluorescent dual-function nano particle with nuclear shell structure

Examples

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Embodiment 1

[0029] Example 1: Preparation of magnetic nanoparticles modified with ATRP initiator

[0030] 1.91gFe 3 o 4 Magnetic nanoparticles (MNPs) were dispersed in 50 mL of dewatered toluene by ultrasound (20 minutes) to form a homogeneously dispersed suspension;

[0031] Then add 6mL of APTES (0.025mol), stir at normal temperature for 12 hours to obtain APTES modified magnetic nanoparticles, wash with ethanol and dichloromethane 4-5 times respectively, separate with magnet, the prepared silanized magnetic nanoparticles For the modification of the initiator in the next step;

[0032] Disperse the above-mentioned APTES-modified magnetic nanoparticles in 50 mL of dried dichloromethane (DCM), add 6 mL (0.042 mol) of triethylamine to it, and put it in an ice-water bath until the temperature drops to 0 ° C. After 2 hours 5 mL of bromoisobutyryl bromide (0.039 mol) was added dropwise thereto, and stirred for 12 hours.

[0033] All the above experiments were carried out under the protectio...

Embodiment 2

[0034] Example 2: Using styrene carbazole (VBK) as a monomer to synthesize nanoparticles with fluorescent magnetism

[0035] Take monomer (VBK) 200mg (7.1×10 -1 mmol), embodiment one gained initiator 10mg (7.1 * 10 -3 mmol), catalyst (FeCl 3 ·6H 2 O) 7mg (2.6×10 -2 mmol), ligand (TDA) 16.5μL (5.2×10 -2 mmol), DMF2mL, vitamin C 9mg (5.1×10 -2 mmol) in a 5mL ampoule, directly seal the tube under air atmosphere, place the sealed ampoule in an oil bath at a constant temperature (90°C) and react for a predetermined time (4-14h).

[0036] After the reaction, take out the sealed tube, immediately cool it with cold water, open the sealed tube, dissolve it in tetrahydrofuran and centrifuge for 3 to 4 times, and finally precipitate it with methanol to obtain fluorescent and magnetic nanoparticles Fe 3 o 4 @PVBK, the average particle size of the nanoparticles is 130nm.

[0037] The molecular weight and distribution of the fluorescent polymers grafted on the magnetic nanoparticles...

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Abstract

The invention discloses a preparation method of a magnetic fluorescent dual-function nano particle with nuclear shell structure, comprising the following steps: (1) magnetic nano particles are prepped by a conventional method, and then the magnetic nano compound particles with amination surfaces are obtained by adopting the conventional method; bromo-alkyl acylbromide is adopted to react with the amino on the surface of the amino, so as to obtain the initiator-modified magnetic nano particles; (2) the initiator obtained in the step (1), fluorescent monomers, catalyst, ligand and reducing agents form a polymerization system, and the polymerization system is dissolved in solvent, the shell formed by fluorescence polymers is obtained by carrying out electronic activation regeneration atom transfer radical polymerization, so as to obtain the magnetic fluorescent dual-function nano particle with nuclear shell structure; as the invention adopts the fluorescent monomers to carry out active radical polymerization directly, and the obtained grafting fluorescent polymer shell is linked on the surface of the magnetic nano particles in a covalent way, so as to be beneficial to maintaining stable performance of the magnetic fluorescent dual-function nano particle with nuclear shell structure in the practical using process.

Description

technical field [0001] The present invention relates to a method for preparing magnetic fluorescent bifunctional nanoparticles with a core-shell structure, in particular to an active radical polymerization using AGET ATRP (ATRP using Activators Generated by ElectronTransfer, atom transfer radical polymerization that generates a catalyst through electron transfer) Methods A method for controllably preparing magnetic and fluorescent bifunctional nanoparticles. Background technique [0002] Nanoparticles with magnetic and fluorescent dual functions have broad application prospects in biomedical fields such as magnetic resonance imaging (MRI) and biomarkers. According to the structure of different magnetic / fluorescent nanomaterials, their preparation strategies can be divided into the following eight types: (1) the magnetic core is encapsulated by a silica shell containing fluorescent substances; (2) magnetic nanoparticles coated with fluorescent substances modified polymers (3...

Claims

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Application Information

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IPC IPC(8): C08F292/00C09K11/06
Inventor 程振平刘纪亮朱秀林张丽芬张正彪
Owner SUZHOU UNIV
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