Pharmaceutical composition used for alimentary canals and application thereof

A composition and digestive tract technology, applied in the direction of drug combination, silicon compound active ingredients, digestive system, etc., can solve the problems of lack of simethicone, pepsin, pronase, etc., and achieve uniform and stable drug quality, good drug selection, Guaranteed safety effect

Active Publication Date: 2010-08-18
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no relevant report on the combined u

Method used

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  • Pharmaceutical composition used for alimentary canals and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Preparation of pepsin silicone oil composition granules

[0069] 1. Prescription:

[0070] Simethicone 40g

[0071] Calcium hydrogen phosphate 40g

[0072] Pepsin (1200 units: 1g) 400g

[0073] Lactose 400g

[0074] Croscarmellose Sodium 15g

[0075] 10% starch slurry 20g (calculated as starch)

[0076] Magnesium stearate 8g

[0077]

[0078] A total of 1000 bags were made

[0079] 2. Process steps:

[0080] (1) Simethicone and absorbent calcium hydrogen phosphate are mixed evenly and set aside;

[0081] (2) Take pepsin, croscarmellose sodium, and lactose according to the prescription amount, add a mixture of simethicone and calcium hydrogen phosphate, mix well, use 10% starch slurry as a binder to granulate, and pass 24 Mesh sieve, dry at 40°C for 1.5 hours, granulate with 18 mesh, add magnesium stearate, mix evenly, pack into bags, 0.92g / bag.

[0082] 3. Clinical use

[0083] 20 minutes ...

Embodiment 2

[0085] Preparation of Pepsin Silicone Oil Composition Powder

[0086] 1. Prescription:

[0087] Simethicone 80g

[0088] Calcium hydrogen phosphate 80g

[0089] Pepsin (1200 units: 1g) 400g

[0090] Sucrose powder 400g

[0091] Crospovidone (XL-10) 20g

[0092] Silica 14g

[0093]

[0094] A total of 1000 bags were made

[0095] 2. Process steps:

[0096] (1) Simethicone and absorbent calcium hydrogen phosphate are mixed evenly and set aside;

[0097] (2) Weigh pepsin, sucrose powder, and crospovidone (XL-10) according to the prescription amount, add a mixture of simethicone and calcium hydrogen phosphate, mix well, finally add silicon dioxide, mix well, pack into bags, 0.98g / bag.

[0098] 3. Clinical use

[0099] 20 minutes before digestive endoscopy and treatment or imaging examination, take 1 bag of pepsin silicone oil composition powder, dissolve and disperse with about 50 ml of water a...

Embodiment 3

[0101] Preparation of Pepsin Silicone Oil Composition Suspension

[0102] 1. Prescription:

[0103] Simethicone 50g

[0104] Silica 2.5g

[0105] Pepsin (1200 units: 1g) 100g

[0106] Microcrystalline Cellulose 30g

[0107] Xanthan gum 5g

[0108] Aspartame 5g

[0109] Ethylparaben 2g

[0110] Disodium edetate 1g

[0111] Ethanol 20g

[0112] 1M sodium hydroxide solution appropriate amount

[0113]

[0114] Purified water up to 1000ml

[0115] 2. Process steps:

[0116] (1) Pepsin, microcrystalline cellulose, and xanthan gum are passed through a 100-mesh sieve respectively, and set aside; purified water is boiled and deoxidized, set aside; sodium hydroxide is prepared into a sodium hydroxide solution with a concentration of 1M, set aside;

[0117] (2) After mixing simethicone and silicon dioxide, place it at 150°C for 3 hours, take it out after cooling, and obtain mixture I; dissolve ethyl p-hydroxybenzoate in ethanol to obtain soluti...

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PUM

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Abstract

The invention discloses a pharmaceutical composition used for alimentary canals and application thereof. The composition comprises a first pharmacology active component A containing at least one digestive enzyme and a second pharmacology active component B containing at least one silicone oil analogue. The composition can be made into various pharmaceutically acceptable formulations; the invention also relates to the application of the composition in preparing adjuvant drugs which are administrated before digestive endoscopy examination and treatment or iconography examination. The composition has both very strong defoaming function and grume removal function, and thereby, the view definition of the digestive endoscopy examination and treatment or the iconography examination can be effectively improved, misdiagnosis and missed diagnosis are reduced and the treatment availability is improved, which are beneficial to the early diagnosis discovery of digestive tract diseases.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a pharmaceutical composition for the digestive tract and its application. The composition comprises a first pharmacologically active component A containing at least one digestive enzyme and at least one silicone oil The second pharmacologically active component B of the analogue, and the application of the composition in the preparation of adjuvant medicine for digestive endoscopy and treatment or imaging examination. Background technique [0002] Digestive endoscopy plays a very important role in the diagnosis of gastrointestinal diseases. It is favored by doctors because of its intuitiveness and simplicity, and it is especially commonly used in clinical diagnosis and treatment. However, due to the presence of a large amount of foam and mucus in the digestive tract, the visual field is unclear, the examination time is prolonged, the patient’s pain is increased, and it i...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61P1/00A61P43/00A61K31/695A61K31/80
Inventor 王国华赵小萍刘萍李侠杨勇
Owner 四川健能制药有限公司
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