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Use of dirithromycin in the preparation of medicaments for the treatment of chronic non-infectious respiratory diseases

A technology of dirithromycin and a drug is applied in the field of medicine to achieve the effects of improving the quality of life, reducing the frequency of acute attacks and improving symptoms

Active Publication Date: 2011-12-14
湖北舒邦药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Studies have found that macrolides not only have antibacterial effects, but also have anti-inflammatory and immune regulation effects, but erythromycin has not been used to treat diffuse panbronchitis, bronchial asthma, and bronchial cystic fibrosis at home and abroad. , bronchiectasis, bronchiolitis obliterans, chronic obstructive pulmonary disease, chronic sinusitis, nasal polyps and other chronic non-infectious respiratory diseases

Method used

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  • Use of dirithromycin in the preparation of medicaments for the treatment of chronic non-infectious respiratory diseases
  • Use of dirithromycin in the preparation of medicaments for the treatment of chronic non-infectious respiratory diseases
  • Use of dirithromycin in the preparation of medicaments for the treatment of chronic non-infectious respiratory diseases

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Experimental program
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Effect test

Embodiment 1

[0029] Embodiment 1: the clinical research of dirithromycin treatment chronic sinusitis (not containing nasal polyps)

[0030] Chronic sinusitis is one of the most common diseases in the Department of Otorhinolaryngology. The main treatments are drugs such as glucocorticoids and macrolide anti-inflammatory treatments and nasal endoscopic surgery. The present invention selects the CRS patient who does not want surgical treatment, and accepts dirithromycin for conservative treatment. The specific research methods and observation results are as follows:

[0031] case selection

[0032] According to the diagnostic criteria in the "Guidelines for the Diagnosis and Treatment of Chronic Rhinosinusitis" (2008, Nanchang), selected chronic sinusitis patients without nasal polyps who were unwilling to undergo surgery from outpatients in the Department of Otolaryngology and had nasal congestion, runny nose, and headache , hyposmia and other symptoms, nasal endoscopy showed nasal mucosa c...

Embodiment 2

[0069] Embodiment 2: the clinical research of dirithromycin treatment chronic sinusitis (containing nasal polyps)

[0070] Chronic sinusitis complicated with nasal polyps is common in clinical practice. Surgery and / or drug treatment are mainly used. Drug treatment before surgery can help reduce inflammation, shrink polyps, and reduce surgical risks. Postoperative medication can help stabilize surgical results and reduce recurrence. We used a low dose (1 / 4 of the antibacterial daily dose) of dirithromycin 125mg, qd, to treat 47 patients with chronic sinusitis and nasal polyps for 3 to 6 months, and found that dirithromycin can significantly improve chronic sinusitis and nasal polyps. Patients with polyps have symptoms such as nasal congestion, runny nose, headache, and hyposmia, shrinking polyps, and the effect is similar to that of roxithromycin, but patients taking dirithromycin have fewer adverse reactions and better compliance. The specific research methods and observation ...

Embodiment 3

[0113] Embodiment 3: the clinical research of dirithromycin treatment adult's bronchial asthma (BA)

[0114] We used dirithromycin enteric-coated tablets (Pinglida) combined with routine asthma treatment and received better therapeutic effect. details as follows:

[0115] case screening

[0116] According to the diagnostic criteria for bronchial asthma established by the Chinese Medical Association, mild and moderate asthma patients in the non-acute attack period were screened from outpatients in the respiratory department, and other diseases that could cause asthma or dyspnea were excluded. All patients had not used sugar within one month. Corticosteroids, no theophylline within 24 hours, no β within 6 hours 2 receptor agonist.

[0117] case grouping

[0118] The 36 patients who met the inclusion criteria were randomly divided into two groups. The treatment group consisted of 20 cases, 12 males and 8 females, aged 19-64 years, with an average age of 36.8 years; the contr...

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Abstract

The invention relates to the field of medicine, and discloses the use of dirithromycin in the preparation of medicines for treating chronic non-infectious respiratory diseases, which include chronic rhinitis and sinusitis, bronchial asthma, and chronic obstructive pulmonary disease , diffuse panbronchiolitis, bronchial cystic fibrosis, bronchiectasis, and bronchiolitis obliterans. Dirithromycin can significantly improve subjective symptoms and objective signs when used in the treatment of chronic non-infectious respiratory diseases, with few adverse reactions and good patient compliance, so it has a good clinical application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of dirithromycin in the preparation of medicines for treating chronic non-infectious respiratory diseases. Background technique [0002] Macrolide antibiotics (MA) are weakly basic antibiotics produced by Streptomyces. erythromycin is the most typical representative of macrolide antibiotics, commonly used are roxithromycin, clarithromycin, dirithromycin (14 rings), azithromycin (15 ring), josamycin, midecamycin, spiramycin (16 rings). [0003] For a long time, macrolide antibiotics have been mainly used in the treatment of infectious diseases caused by sensitive bacteria. Their mechanism of action is to bind to the 50s and 30s subunits of ribosomes of sensitive microorganisms to inhibit the synthesis of bacterial proteins, thereby inhibiting bacterial growth and reproduction. . In addition to good antibacterial activity against gram-positive bacteria, macrolide antibiotics have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P11/00A61K31/706A61P11/02A61P11/06
Inventor 周海波朱强洪鸣龚明峰
Owner 湖北舒邦药业有限公司
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