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Hot-melt pressure-sensitive adhesive transdermal patch containing alpha-asarone and preparation method thereof

A technology of hot-melt pressure-sensitive adhesive and transdermal patch, which can be applied to non-active ingredients in medical preparations, pharmaceutical formulations, ether/acetal active ingredients, etc., and can solve the problems of emulsifier migration, high energy consumption, Problems such as slow drying speed, to achieve the effect of fast coating speed, high degree of automation, and low product cost

Inactive Publication Date: 2010-10-06
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Most of the pressure-sensitive adhesives used as the main material of transdermal drug delivery patches are solvent-based, which is accompanied by problems such as environmental pollution and high energy consumption.
Emulsion-type pressure-sensitive adhesives developed in recent years are also limited due to slow drying speed and emulsifier migration.

Method used

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  • Hot-melt pressure-sensitive adhesive transdermal patch containing alpha-asarone and preparation method thereof
  • Hot-melt pressure-sensitive adhesive transdermal patch containing alpha-asarone and preparation method thereof
  • Hot-melt pressure-sensitive adhesive transdermal patch containing alpha-asarone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of hot melt pressure sensitive adhesive:

[0048] Get 100g of styrene-isoprene-styrene triblock copolymer (Kraton, SIS-1161), 140g of hydrogenated petroleum resin (Lanzhou Huifeng Petrochemical Priority Company, 1#), 50g of liquid paraffin, N, N - Zinc dibutylcarbamate 2 g. After mixing the above materials, heat to 160°C to 180°C under the protection of nitrogen, stir for 2 hours, and cool down.

[0049] After testing, the melting point of the prepared hot-melt pressure-sensitive adhesive was 80°C.

Embodiment 2

[0051] Preparation of hot melt pressure sensitive adhesive:

[0052] Get 100g of styrene-isoprene-styrene triblock copolymer (Kraton, SIS-1161), 80g of hydrogenated petroleum resin (Lanzhou Huifeng Petrochemical Priority Company, 1#), dibutyl phthalate 40g, propyl gallate 2g. After mixing the above materials, heat to 160°C to 180°C under the protection of nitrogen, stir for 2 hours, and cool down.

[0053] After testing, the melting point of the prepared hot-melt pressure-sensitive adhesive was 126°C.

Embodiment 3

[0055] Preparation of hot melt pressure sensitive adhesive:

[0056] Get 100g of styrene-isoprene-styrene triblock copolymer (Kraton, SIS-1161), 160g of hydrogenated petroleum resin (Lanzhou Huifeng Petrochemical Priority Company, 1#), 80g of liquid paraffin, 2,6 - Di-tert-butyl-p-cresol 2 g. After mixing the above materials, heat to 160°C to 180°C under the protection of nitrogen, stir for 2 hours, and cool down.

[0057] After testing, the melting point of the prepared hot-melt pressure-sensitive adhesive was 72°C.

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Abstract

The invention discloses a hot-melt pressure-sensitive adhesive transdermal patch containing alpha-asarone, which comprises a back lining, a storage warehouse layer and an anti-sticking layer. The storage warehouse layer is prepared from the following raw materials in percentage by weight: 1-20 percent of alpha-asarone, 70-98 percent of hot-melt pressure-sensitive adhesive and 1-10 percent of transdermal accelerant. The transdermal patch adopts the hot-melt pressure-sensitive adhesive with both hot-melt and pressure-sensitive properties as a base material, has the advantages of no organic solvent and low pollution nuisance; in addition, the preparation of the transdermal patch has the advantages of high coating speed and high degree of automation.

Description

technical field [0001] The invention relates to the field of transdermal patches, in particular to a hot-melt pressure-sensitive adhesive transdermal patch containing α-asarone and a preparation method thereof. Background technique [0002] α-Asarone, also known as α-Asarone or Asarone, has a chemical name of 2,4,5-trimethoxy-phenylprop-1-ene, and is one of the main active ingredients in the Araceae plant Shichangpu , has the following general structure: [0003] [0004] Since the 1960s, extensive research on α-asarone has been carried out at home and abroad, and it has been confirmed that it has strong pharmacological activity, and has the functions of relieving cough, eliminating phlegm, relieving asthma, sedation, relieving spasm and anticonvulsant. It has anti-cancer activity on human cancer cells; it also has different degrees of inhibitory effects on the growth of Diplococcus pneumoniae, Staphylococcus aureus and Escherichia coli. α-Asarone is mainly used in the ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/09A61K47/32A61K47/44A61P11/00A61K47/46
Inventor 梁文权
Owner ZHEJIANG UNIV
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