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Purpose and application of R'-beta-D-fructopyranoside in preparing medicament for preventing and treating cancer cell diffusion transfer

A technology of cancer cell proliferation and fructopyranose, which is applied in the field of drug preparation for the prevention and treatment of cancer proliferation and metastasis, and can solve problems such as increased osmotic pressure, hemolysis, and damage to the normal penetration of red blood cells.

Inactive Publication Date: 2010-10-13
杨浚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0059] There are problems in the development of traditional Chinese medicine triterpenoid saponins to prevent and treat cancer diffusion and metastasis: saponin aqueous solution can combine with cholesterol on the red blood cell wall to form a water-insoluble molecular complex, which destroys the normal osmosis of red blood cells and increases the intracellular osmotic pressure. Disintegration occurs, which leads to hemolysis. Therefore, there are hemolysis problems in the development of triterpenoid saponins to prevent and treat cancer diffusion and metastasis, and they cannot be used for intravenous injection in particular.

Method used

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  • Purpose and application of R'-beta-D-fructopyranoside in preparing medicament for preventing and treating cancer cell diffusion transfer
  • Purpose and application of R'-beta-D-fructopyranoside in preparing medicament for preventing and treating cancer cell diffusion transfer
  • Purpose and application of R'-beta-D-fructopyranoside in preparing medicament for preventing and treating cancer cell diffusion transfer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Example 1: Extraction of total sugars containing "n-butyl-O-β-D-fructopyranoside (n-butyl-O-β-D-fructopyranoside)":

[0125] ① Weigh 100 kg of water, pour it into a 1000 liter container, add 16 kg of hydrochloric acid, and stir well (PH4). Then add 0.3 kg of cellulase and stir evenly.

[0126] ② Weigh 100 kg of natural plant vine root, remove silt and weeds; crush it into about 20 meshes, pour it into the enzymolysis solution in the above container, and stir for 6 hours for enzymolysis;

[0127]③ Pour the vine pear root treated by the above enzymatic hydrolysis into a 1000-liter microwave and ultrasonic extraction kettle, and extract at a temperature of 60-70°C for 80 minutes;

[0128] ④Use a "solid-liquid" separation device to separate the wisteria root powder from the extract.

[0129] ④ Filtrate and concentrate the extract to obtain the total glycosides containing "n-butyl-O-β-D-fructopyranoside"

[0130] concentrated extract;

[0131] ⑤ Add the total glycoside c...

Embodiment 2

[0134] Embodiment 2: Extract other anticancer components such as triterpenoids and anthraquinones in the root of wisteria

[0135] 1. take by weighing 100 kilograms (moisture 30%) of the wisteria root powder that " ④ " step separates in " embodiment 1 ", add the ethanol of an amount of 80-95% to the ethanol concentration of whole solution to be 75%.

[0136] ②Microwave and ultrasonic extraction, the extraction temperature is 60-75°C, and the extraction time is 30-360 minutes;

[0137] ③ solid-liquid separation;

[0138] ④ Liquid-phase filtration, concentration, and recovery of ethanol to obtain 5-10 kg of concentrated extract;

[0139] ⑤Remove impurities such as protein;

[0140] ⑥ recovery of solvent;

[0141] ⑦ Concentrate and dry to obtain 3-7 kg of triterpenoids, anthraquinones and other anticancer ingredients.

Embodiment 3

[0142] Example 3: Preparation of intravenous infusion of "n-butyl-O-β-D-fructopyranoside" for preventing and treating the spread and metastasis of gastric cancer

[0143] ① Weigh 5.5 kg of total glycosides containing "n-butyl-O-β-D-fructopyranoside (n-butyl-O-β-D-fructopyranoside)" extracted in "Example 1";

[0144] ② Add distilled water until the total glycosides containing "n-butyl-O-β-D-fructopyranoside (n-butyl-O-β-D-fructopyranoside)" are completely dissolved.

[0145] ③ filter

[0146] ④ Add 95% ethanol to the filtrate, and adjust the ethanol concentration to 80%.

[0147] ⑤ Precipitation, filtration; recovery of ethanol;

[0148] ⑥ Drying to obtain high-purity total glycosides containing "n-butyl-O-β-D-fructopyranoside (n-butyl-O-β-D-fructopyranoside)";

[0149] ⑦ Add 5 kg of high-purity total glycosides containing "n-butyl-O-β-D-fructopyranoside" to distilled water or a medically acceptable carrier, Fully dissolved and prepared as a 50% infusion solution;

[0150]...

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Abstract

The invention discloses a purpose and application of R'-beta-D-fructopyranoside in preparing a medicament for preventing and treating cancer cell diffusion transfer. The medicament for preventing and treating cancer cell diffusion transfer is prepared by firstly utilizing the depression action of R'-beta-D-fructopyranoside on cancer cell diffusion transfer and is clinically applied to preventing and treating cancer cell diffusion transfer of digestive systems such as gastric cancer, liver cancer, intestinal cancer and the like; when matching with concurrent chemoradiotherapy for preventing and treating cancer cell diffusion transfer, the invention achieves the remarkable high-efficiency and low-toxicity effects that the normal retention rate of the hematic convention of a patient is 70 percent, the normal retention rate of blood T lymphocell subgroup is 70 percent, and the normal retention rate of hepatic / renal function is over 80 percent, and solves the problem that no medicaments for preventing and treating cancer cell diffusion transfer appear till now.

Description

technical field [0001] The invention belongs to the field of preparation of drugs for the prevention and treatment of cancer diffusion and metastasis, and in particular relates to the use of "R'-β-D-fructopyranoside (R'-β-D-fructopyranoside)" to prepare drugs for preventing and treating gastric cancer diffusion and metastasis and applications. Background technique [0002] Gastric cancer is one of the common malignant tumors in my country, and it is extremely harmful. The mortality rate of gastric cancer in men is as high as 40.8 / 100,000, and that of women is as high as 18.6 / 100,000, which are 4.2-7.9 times and 3.8-8.0 times that of developed countries in Europe and America. The mortality rate ranks first among all kinds of tumors. [0003] Gastric cancer treatment mainly includes surgery, radiation therapy, and chemotherapy. Early gastric cancer is mostly asymptomatic or only has mild symptoms. When the clinical symptoms are obvious, the lesion is already in the advanced s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61K31/351A61K31/704A61P35/00A61P35/04
Inventor 杨浚
Owner 杨浚
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