Crystallization method of cefcapene ester hydrochloride monohydrate

Abstract

The invention relates to a crystallization method of cefcapene ester hydrochloride monohydrate, which belongs to the field of medicine. The method comprises the following steps: adding solvents into cefcapene ester hydrochloride for dissolution; adding active carbon for decolourization; carrying out filtration and washing; adding hydrochloric acid water solution into obtained filter liquid for carrying out crystallization; filtering crystals; respectively washing the crystals by water and ethyl acetate; and carrying out drying to obtain the cefcapene ester hydrochloride monohydrate. The method of the invention can use a single solvent of methanol for crystallization to improve the recovery yield and reduce the production cost, and can also use mixed solvents of the methanol and ketone for crystallization to improve the quality of finished product. Low-temperature active carbon is used for decolourization, and the impurity control in the operation process can be ensured at the same time of ensuring the product quality (the control on the color grade, the endotoxin and the like). The baking temperature is reduced, the baking time is shortened, and the quality such as the color grade, the impurity content and the like of the products can be reached. The invention has the advantages of simplicity, easy implementation, low cost, good crystallization clarity, good color grade and easy control on the impurities of the finished products, is suitable for large-scale popularized application, and has obvious economic benefits.

Description

technical field

[0001] The invention relates to a crystallization method of cefcapene hydrochloride monohydrate, which belongs to the field of medicines. Background technique

[0002] Cefcapene pivoxil hydrochloride is the third generation of oral cephalosporin antibiotics, used for the treatment of superficial infection caused by sensitive bacteria, deep skin infection, chronic pyoderma, secondary infection of wounds such as trauma, burns and surgical trauma, mastitis , perianal abscess, pharyngitis, laryngitis, tonsillitis (including peritonsillar inflammation, peritonsillar abscess), acute bronchitis, pneumonia, secondary infection of chronic respiratory diseases, cystitis, pyelonephritis, urethritis, cervicitis , cholecystitis, cholangitis, intrauterine infection, uterine adnexitis, dacryocystitis, stye, meibomitis, otitis externa, otitis media, sinusitis, dental tissue infection, periodontitis, jaw inflammation, etc. Cefcapene pivoxil hydrochloride is an ester-type p...

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