Glucosamine modified poly (ethylene glycol) diacrylate (PEGDA) hydrogel, preparation method and application thereof

A technology of glucosamine hydrochloride and glucosamine, which is applied in medical science, prostheses, etc., can solve the problems of lack of biological activity and cell identification signals, unfavorable cell-specific gene activation, etc., to achieve large-scale production, good biological Compatibility, the effect of simple process
CN101864046AActive Publication Date: 2010-10-20SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2010-10-20

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Abstract

The invention discloses a glucosamine modified poly (ethylene glycol) diacrylate (PEGDA) hydrogel, a preparation method and application thereof. The glucosamine modified poly (ethylene glycol) diacrylate hydrogel contains 10-30 percent of poly (ethylene glycol) diacrylate, 1.0-10mM of acryloyl or propenyl glucosamine and 0.03-0.1 percent of initiating agent I2959. The preparation method comprises the steps of: preparing the PEGDA by using polyethyleneglycol as a basic material; preparing the acryloyl or propenyl glucosamine by using glucosamine hydrochloride as a raw material; and preparing a water solution or PBS (Poly (Butadiene-Styrene) solution by using the acryloyl or propenyl glucosamine and the initiating agent I2959 in a certain proportion, and can be cured into the hydrogel after being irradiated by ultraviolet with 365nm wavelength. The hydrogel can be used for tissue repair of clinical medicine, has simple preparation process, can realize in situ injection forming, meet the requirement on minimally invasive procedure, and has better application prospect and scientific significance.
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Description

technical field

[0001] The invention relates to a modified biological material and its preparation technology, in particular to a glucosamine modified polyethylene glycol diacrylate hydrogel with good biocompatibility and biological activity, its preparation method and application. Background technique

[0002] Glucosamine is a structural unit of glycosaminoglycan, hyaluronic acid, which constitutes the extracellular matrix of cartilage. Glucosamine hydrochloride or sulfate, as a clinical drug for the treatment of osteoarthritis, can relieve the pain of patients and reduce the narrowing of the joint cavity. Although its pharmacological effects are still unclear, in vitro experiments have shown that a certain concentration (2mM added to the medium) of glucosamine can promote the secretion of proteoglycan and collagen II in three-dimensional cultured chondrocytes, and can up-regulate the expression of TGFb-1 in chondrocyte mRNA ; Can promote three-dimensional culture of embry...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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