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New application of golden thread processed product

A use, the technology of Coptis chinensis is applied in the pharmaceutical field of preparing insulin sensitizers and PPARγ agonists to achieve the effects of improving the treatment of diabetes and its complications, improving insulin resistance and clarifying drug efficacy

Inactive Publication Date: 2010-11-03
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine Coptis chinensis is also commonly used in the prescription of Chinese patent medicines for the treatment of diabetes. In 2006, the analysis results of diabetes medication in domestic hospitals showed that among the top ten products, Tangmaikang granules (including Coptis chinensis, with a market share of 22.1 %, about 100 million yuan), Jinqi Jiangtang Tablets (including Coptis chinensis, with a market share of 11.6%, about 50 million yuan), ranking 2nd and 4th respectively, are widely used in TCM clinical practice, but in TCM clinical practice Proposed that "Huanglian is not the main medicine for treating diabetes (diabetes)"

Method used

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  • New application of golden thread processed product
  • New application of golden thread processed product
  • New application of golden thread processed product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 The preparation of the processed product of Coptidis officinalis of the present invention

[0025] Take Evodia rutaecarpa and add appropriate amount of water to decoct, mix the decoction with Jinghuanglian, wait for the liquid to be absorbed, and fry to dry. For every 100kg of net coptis, use 10kg of Evodia rutaecarpa.

experiment example 2

[0026] Experimental Example 2 Preparation of Extract from Cornus Rhizoma Coptis Rhizome Processed Products of the Present Invention

[0027] Take the net Yuzhi Coptis chinensis, add water to decoct 3 times, 3 hours each time, add 10 times the amount of water each time, filter, combine the extracts, concentrate, and set aside.

[0028] According to the above process, the extracts of Coptis chinensis and Coptis chinensis were extracted and prepared, and the content of total polysaccharides was also determined on the basis of the determination of total alkaloids.

[0029] Determination method of total alkaloids: Accurately weigh 0.4g of the extract, put it into a 25mL measuring bottle, add ethanol to dilute to the mark, shake well, and test by column chromatography. Precisely measure 5mL, put it on the treated alumina column (about 0.9cm inner diameter, 5g neutral alumina, wet packing, pre-wash with 30mL ethanol), elute with 35mL ethanol, collect the eluate and put it in 50mL In...

Embodiment 3

[0034] Embodiment 3 The quality control method of Huanglian of the present invention

[0035] (1) TLC identification

[0036]Take 0.1g of this product powder, add methanol 50ml, ultrasonic treatment for 30min, and the filtrate is used as the test solution. Take jatrorrhizine hydrochloride, tetrandrine hydrochloride, epiberberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride and berberine hydrochloride plus methanol to make a solution containing 0.1 mg per 1 ml, as a reference solution. Precisely measure 1.5ml of each reference substance solution and add it to the same 10ml measuring bottle, dilute to the mark with methanol, and use it as a mixed reference substance solution. According to the test of thin-layer chromatography (Appendix VI B of the Chinese Pharmacopoeia in 2005), draw 10 μl of each of the above-mentioned three solutions, respectively spot on the same silica gel G thin-layer plate, and use cyclohexane-ethyl acetate-isopropanol- Methanol-ammoni...

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PUM

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Abstract

The invention provides application of golden thread in preparing medicaments, such as an insulin sensitizer and a PPAR-gamma agonist, in particular relates to application in restraining 3T3-L1 pre-adipocyte cell differentiation, enhancing the utilization ratio of 3T3-L1 pre-adipocyte glucose or reducing blood fat and improving insulin resistance or diabetes medicaments. The invention also provides a medicinal composition for restraining 3T3-L1 pre-adipocyte cell differentiation and enhancing the utilization ratio of glucose. The golden thread and the extract thereof have the advantages of restraining 3T3-L1 pre-adipocyte cell differentiation, improving insulin resistance and treating diabetes and complicating diseases thereof, and achieving remarkable medicament effect which is superior to that of berberine hydrochloride and crude golden thread.

Description

technical field [0001] The invention relates to a new application of Yuhuanglian, in particular, the application in the preparation of drugs for insulin sensitizers and PPARγ agonists. Background technique [0002] According to the World Health Organization's "2008 World Health Report": the combination of urbanization, aging and global lifestyle changes has made chronic non-communicable diseases such as diabetes an increasingly important cause of disease and death. According to the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2007 Edition)" issued by the Diabetes Society of the Chinese Medical Association: Type 2 diabetes is the main type (93.7%) of the diabetic population in China, and it is expected to reach 55 million people in 2025. Diabetes belongs to the category of "diabetes" disease in traditional Chinese medicine. According to the theory of traditional Chinese medicine, the pathogenesis of "diabetes" is: due to eating too much fat and sw...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P5/50A61P3/10A61P3/06
Inventor 赖先荣孟宪丽张艺李佳川郑海杰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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