Compound preparation for treating relevant vascular diseases and preparation method thereof

The technology of compound preparation and compound tablet, which is applied in the field of medicine, can solve the problems of inability to effectively improve the symptoms of intermittent claudication in patients with peripheral arterial occlusion, and achieve the effects of significant vascular-related diseases, simple production process and long shelf life.

Active Publication Date: 2010-11-10

XIAN LIBANG PHARMA

3 Cites 2 Cited by

AI-Extracted Technical Summary

Problems solved by technology

However, Mohler et al. found that beraprost sodium could not effectively improve the symptoms of intermittent claudication in patients with periphe...

Abstract

The invention belongs to the field of pharmacy, and in particular relates to a compound preparation for treating relevant vascular diseases. The compound preparation consists of the following two active ingredients: beraprost or a pharmaceutically-acceptable salt thereof and cilostazol or a pharmaceutically-acceptable salt thereof, wherein the weight ratio of the beraprost or the pharmaceutically-acceptable salt thereof to the cilostazol or the pharmaceutically-acceptable salt thereof is 0.5-2: 750-3,000.

Application Domain

Organic active ingredientsBlood disorder +2

Technology Topic

CilostazolVascular disease +8

Image

Examples

Experimental program(8)

Example Embodiment

[0075] Example 1 Preparation of compound tablets

[0076] formula:

[0077]

[0078]

[0079] Preparation:

[0080] (1) After mixing the prescription amount of beraprost sodium, cilostazol, cross-linked polyvinylpyrrolidone and sodium lauryl sulfate, place it in a grinder and grind to obtain a solid dispersion powder with a particle size of less than 50μm ;

[0081] (2) Add the prescribed amount of starch, use 5% polyvinylpyrrolidone and 50% ethanol aqueous solution to make a soft material, pass through a 20-mesh sieve, and ventilate and dry at 35°C;

[0082] (3) After drying, add the prescribed amount of magnesium stearate and mix, granulate and compress to obtain compound tablets.

Example Embodiment

[0083] Example 2 Preparation of sustained-release compound tablets

[0084] formula:

[0085]

[0086] Preparation:

[0087] (1) After mixing the prescription amount of beraprost sodium, cilostazol, cross-linked polyvinylpyrrolidone, sodium lauryl sulfate, and sodium hydroxypropyl cellulose uniformly, place them in a grinder to obtain the particle size It is a solid dispersion powder below 50μm;

[0088] (2) Add the prescription amount of starch, use 5% polyvinylpyrrolidone and 50% ethanol aqueous solution to make soft material, pass through a 20-mesh sieve, and ventilate and dry at 35℃;

[0089] (3) After drying, add the prescribed amount of magnesium stearate, mix well, granulate and compress to obtain compound tablets.

Example Embodiment

[0090] Example 3 Preparation of compound capsules

[0091] formula:

[0092]

[0093] Preparation:

[0094] Take the prescription amount of beraprost sodium and cilostazol and gradually dilute the prescription amount of starch according to the same amount of addition method, add the prescription amount of antioxidant vitamin C and mix well, add an appropriate amount of 10% starch slurry, granulate, dry, Whole granules, then choose moisture-proof and anti-oxidation coating powder to coat, dry, sieving, and encapsulate.

PUM

Property	Measurement	Unit
Particle size	<= 50.0	µm

Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

good stability

Compound preparation for treating relevant vascular diseases and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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