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Hydrolysable non-inflammatory polymer serving as medicament delivery carrier

A transmission carrier and hydrolyzable technology, applied in the direction of non-active components of polymer compounds, etc., to achieve the effect of simple synthesis process, no toxic side effects, and good biocompatibility

Inactive Publication Date: 2012-04-04
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few domestic studies in this field, and there are almost no such carrier materials with independent intellectual property rights.

Method used

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  • Hydrolysable non-inflammatory polymer serving as medicament delivery carrier
  • Hydrolysable non-inflammatory polymer serving as medicament delivery carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] First, 1.0 mmol of α-cyclodextrin was dissolved in 5 ml of 20% sodium hydroxide aqueous solution, 5 mmol of epichlorohydrin was added thereto, and reacted at 20° C. for 3 hours to obtain α-cyclodextrin polymer; then, under nitrogen protection Dissolve 0.5mmol α-cyclodextrin polymer in 10ml N,N-dimethylformamide, add 0.01mmol pyridine p-toluenesulfonate, and add 10mmol 2,2-dimethoxypropane at 20°C React under magnetic stirring; add 0.2 mmol triethylamine to the reaction system after 3 hours to stop the reaction, precipitate in water and vacuum dry to obtain the target polymer.

Embodiment 2

[0019] Firstly, 1.0 mmol of β-cyclodextrin was dissolved in 10 ml of 15% sodium hydroxide aqueous solution, 7 mmol of epichlorohydrin was added thereto, and reacted at 30°C for 3.5 hours to obtain β-cyclodextrin polymer; then, under nitrogen protection Dissolve 0.5mmol β-cyclodextrin polymer in 15ml N,N-dimethylformamide, add 0.012mmol pyridine p-toluenesulfonate, and add 10mmol 2,2-dimethoxypropane at the same time React under magnetic stirring at 0° C.; add 0.1 mmol triethylamine to the reaction system after 3.5 hours to stop the reaction, precipitate in water and dry in vacuum to obtain the target polymer.

Embodiment 3

[0021] Firstly, 1.0 mmol of γ-cyclodextrin was dissolved in 5 ml of 18% potassium hydroxide aqueous solution, 6 mmol of epichlorohydrin was added thereto, and reacted at 25° C. for 3 hours to obtain a γ-cyclodextrin polymer; then, under nitrogen protection Dissolve 0.5mmol γ-cyclodextrin polymer in 10ml N,N-dimethylacetamide, add 0.01mmol pyridine p-toluenesulfonate, and add 20mmol 2,2-dimethoxypropane at 20 ℃ under magnetic stirring; after 5 hours, 0.1 mmol triethylamine was added to the reaction system to stop the reaction, and the target polymer was obtained by precipitation in water and vacuum drying.

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Abstract

The invention discloses a hydrolysable non-inflammatory polymer serving as a medicament delivery carrier. The synthesis method comprises the following steps of: dissolving a certain amount of alpha-cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin in alkaline aqueous solution and adding epichlorohydrin into the mixture to perform reaction at a certain temperature to obtain a cyclodextrin polymer; and dissolving a certain amount of alpha-cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin in an organic solvent, adding a catalyst into the solution and adding an acetalation reagent into the reaction system to perform acetalation reaction for 1 to 10 hours so as to obtain the hydrolysable non-inflammatory polymer.

Description

technical field [0001] The invention relates to a hydrolyzable non-inflammatory polymer as a drug delivery carrier. Background technique [0002] In recent decades, hydrolyzable / degradable polymer materials have received extensive attention in the field of biomedicine [1-3]. Some materials have been applied clinically, for example, poly(lactide-co-glycolide) (PLGA) has been approved by the US FDA as an absorbable suture and a drug release carrier. In addition to being used to prepare sustained and controlled release drug delivery systems, degradable polymer materials are also widely used as scaffold materials for tissue engineering [4]. Generally speaking, degradable polymers can be divided into two categories, namely natural polymers and synthetic polymer materials. Natural polymers mainly include cellulose and its derivatives, chitosan and its derivatives, sodium alginate and its derivatives, collagen, gelatin, etc. [3]. For natural polymer materials, because their mole...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/16A61K47/40
Inventor 李晓辉张建祥李淑慧
Owner ARMY MEDICAL UNIV
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