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Cough-relieving tablets and preparation method thereof

A technology of Keke Tablets and Plain Tablets, which is applied in the direction of medical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of unqualified tablet quality and poor effect, and achieve intermediate The effect of fewer links, low cost and low energy consumption

Active Publication Date: 2010-12-08
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since Keke Tablet medicinal material extract powder contains a large amount of sugar components, wet granulation and high-speed stirring granulation are not effective, which may easily lead to unqualified tablet quality

Method used

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  • Cough-relieving tablets and preparation method thereof
  • Cough-relieving tablets and preparation method thereof
  • Cough-relieving tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 240g of ephedra and 240g of poppy shell, crush them into powder respectively, pass through a 80-mesh sieve to obtain the fine powder and the remaining coarse powder, leave 110g of ephedra fine powder and 110g of poppy shell fine powder for later use; the remaining 130g of ephedra coarse powder and 130g of poppy shell Coarse powder is added with acidic aqueous solution (an acidic aqueous solution whose pH value is adjusted to 5 with 10% hydrochloric acid aqueous solution by volume percentage concentration) decocting twice, the water of 10 times of coarse powder weight is added for the first time, and 8 times of coarse powder is added for the second time. Powder weight water, decocted for 2 hours each time, filtered, and the filtrate was adjusted to pH 7 with 10% sodium hydroxide aqueous solution with a mass percentage concentration to obtain a medicinal solution for subsequent use; the remaining 240g licorice, 240g bitter almonds, and 75g radish Potatoes, 75g platyco...

Embodiment 2

[0051] The preparation of medicinal material extraction ointment powder is the same as that in Example 1.

[0052] Grind the lactose powder, pregelatinized starch, magnesium stearate, microcrystalline cellulose, silicon dioxide and polyethylene glycol 4000 through a 100-mesh sieve respectively, and set aside.

[0053] Put 290g of the above-mentioned lactose powder, 42.8g of pregelatinized starch and 193g of medicinal material extract paste powder into the mixer, start the machine and mix evenly to obtain a premix; add 43.8g of microcrystalline cellulose and 80g of polyethylene glycol 4000 to the In the above premix, mix well to obtain a mixture; put the above mixture into a GZL series dry roller compaction granulator, the pressure of the roller is 80Pa, the speed of the roller is 16 rpm, and the conveying speed of the mixture is 65 rpm. Start the machine, pass through a 40-mesh sieve after granulation, and discharge the material to obtain 613g of granular matter; add the above...

Embodiment 3

[0055] The preparation of medicinal material extraction ointment powder is the same as that in Example 1.

[0056] Grind the lactose powder, pregelatinized starch, magnesium stearate, microcrystalline cellulose, silicon dioxide and polyethylene glycol 4000 through a 100-mesh sieve respectively, and set aside.

[0057] Put 110.8g of the above-mentioned lactose powder, 39.6g of pregelatinized starch and 490g of medicinal material extract paste powder into the mixer, start the machine and mix evenly to obtain a premix; add 39.6g of microcrystalline cellulose and 60g of polyethylene glycol 4000 Put the above mixture into the above premix and mix it evenly to obtain the mixture; put the above mixture into the GZL series dry roller granulator, the pressure of the roller is 60Pa, the speed of the roller is 10 rpm, and the conveying speed of the mixture is 45 rpm , start the machine, pass through a 80-mesh sieve after granulation, and then get 630g of granular matter; add the above-me...

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Abstract

The invention discloses cough-relieving tablets which are prepared by carrying out dry granulation and tablet pressing on medicinal material extract paste powder, lactose powder, microcrystalline cellulose, pregelatinized starch, silicon dioxide, magnesium stearate and polyethylene glycol 4000. The invention further discloses a preparation method of the cough-relieving tablets, which comprises the following steps: firstly uniformly mixing the lactose powder, the pregelatinized starch and the medicinal material extract paste powder, and being uniformly mixed with the microcrystalline cellulose and the polyethylene glycol 4000; and carrying out the dry granulation on the mixed materials, preparing granules, then carrying out final mixing with the magnesium stearate and the silicon dioxide, and carrying out the tablet pressing for preparing the cough-relieving tablets. The tablets prepared by adopting the dry granulation and the tablet pressing can effectively improve the hardness and the stability of the tablets, solve the problems of unqualified disintegration time limit and unqualified microorganisms, further improve the product quality, lead the process flow to be simple, save energy, save cost and be suitable for industrial production.

Description

technical field [0001] The invention relates to a Chinese patent medicine tablet and the field of preparation thereof, in particular to a Keke tablet and a preparation method thereof. Background technique [0002] Keke Tablets is a Chinese patent medicine with the functions of relieving cough, relieving asthma and eliminating phlegm. It can be used to treat cough, shortness of breath, etc. [0003] Existing Keke Tablets are generally prepared according to the State Drug Administration standard YBZ07032005, and the preparation method of the dry paste powder of extracting medicinal materials recorded therein is as follows: take 240g of ephedra and 240g of poppy shells and pulverize them into fine powder, sieve, and set aside 45.8% fine powder for later use; add acidic aqueous solution (use 10% hydrochloric acid solution to adjust the pH value to about 5) and decoct the remaining coarse powder twice, add water 10 times for the first time, add water 8 times for the second time, ...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/20A61K47/38A61P11/06A61P11/10A61P11/14A61K33/06
Inventor 刘全国
Owner HAINAN HULUWA PHARMA GRP CO LTD
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