Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hydroxyapatite hybridized nanometer crystal assembly, preparation method and application thereof

A technology of hydroxyapatite and nanocrystals, applied in nanostructure manufacturing, chemical instruments and methods, nanotechnology, etc., can solve problems such as uneven size distribution, easy agglomeration of particles, poor stability and dispersion of water phase, etc., to overcome size The effect of uneven distribution, uniform size dispersion, and obvious increase

Inactive Publication Date: 2010-12-08
SICHUAN UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The patent application with the publication number CN101559241A discloses a hyaluronic acid-hydroxyapatite nanocomposite ball and its preparation method. Although the composite ball obtained by this method solves the problem of easy aggregation of particles, uneven size distribution, and stable water phase The problem of poor dispersion, and the composition of hyaluronic acid makes the material have specific targeting (CD44 receptor), but because the composite ball is a solid ball formed by the aggregation and growth of basic crystal nuclei, its specific surface area is relatively Smaller, and therefore limited in terms of carrier applications (such as adsorbents)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydroxyapatite hybridized nanometer crystal assembly, preparation method and application thereof
  • Hydroxyapatite hybridized nanometer crystal assembly, preparation method and application thereof
  • Hydroxyapatite hybridized nanometer crystal assembly, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] In this example, the process steps for preparing the hydroxyapatite hybrid nanocrystal assembly are as follows:

[0045] (1) Preparation of hyaluronic acid solution

[0046] Add 0.6kg of hyaluronic acid with a molecular weight of 2.2 million to a reaction vessel filled with 60L of deionized water at normal pressure and room temperature, and dissolve the hyaluronic acid completely under stirring;

[0047] (2) ion slow release diffusion

[0048] Under stirring, it is the Na of 0.36mol / L that the hydrogen phosphate concentration is added in the hyaluronic acid aqueous solution prepared in step (1). 2 HPO 4 2H 2 O aqueous solution 20L to form hyaluronic acid-Na 2 HPO 4 2H 2 O mixed liquor, adjust the pH value of described mixed liquor with the ammoniacal liquor of concentration 0.5mol / L and the HCl of concentration 0.5mol / L, make the pH value of mixed liquor stabilize at 10;

[0049] CaCl with a calcium ion concentration of 0.5 mol / L 2 Put 20L of aqueous solution in...

Embodiment 2

[0054] In this example, the process steps for preparing the hydroxyapatite hybrid nanocrystal assembly are as follows:

[0055] (1) Preparation of Hyaluronic Sodium Hyaluronate Solution

[0056] Add 0.6g of sodium hyaluronate with a molecular weight of 1.8 million to a reaction vessel filled with 60mL of deionized water at normal pressure and room temperature, and completely dissolve the sodium hyaluronate under stirring;

[0057] (2) ion slow release diffusion

[0058] Under stirring, add calcium ion concentration to the sodium hyaluronate aqueous solution prepared in step (1) and be the CaCl of 0.39mol / L 2 Aqueous solution 20mL to form sodium hyaluronate-CaCl 2 For the mixed solution, adjust the pH value of the mixed solution with ammonia water with a concentration of 0.2 mol / L and HCl with a concentration of 0.2 mol / L, so that the pH value of the mixed solution is stabilized at 10;

[0059] The hydrogen phosphate concentration is 0.3mol / L (NH 4 ) 2 HPO 4 2H 2 O aqueo...

Embodiment 3

[0064] In this example, the process steps for preparing the hydroxyapatite hybrid nanocrystal assembly are as follows:

[0065] (1) Preparation of hyaluronic acid solution

[0066] Add 0.06g of hyaluronic acid with a molecular weight of 6 million to a reaction vessel containing 20mL of deionized water at normal pressure and room temperature, and dissolve the hyaluronic acid completely under stirring;

[0067] (2) ion slow release diffusion

[0068] Under stirring, add CaCl with a calcium ion concentration of 1mol / L to the hyaluronic acid solution prepared in step (1). 2 Aqueous solution and K with a hydrogen phosphate concentration of 0.83 mol / L 2 HPO 4 ·3H 2 O aqueous solution 10mL each to form hyaluronic acid-CaCl 2 -K 2HPO 4 ·3H 2 O mixed liquor, adjust the pH value of described mixed liquor with the ammoniacal liquor of concentration 0.5mol / L and the HCl of concentration 0.5mol / L, make the pH value of mixed liquor stabilize at 10;

[0069] The hyaluronic acid-CaCl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
lengthaaaaaaaaaa
Login to View More

Abstract

A hydroxyapatite hybridized nanometer crystal assembly is formed by assembling the nanometer crystals which contain hyaluronic acid and hydroxyapatite. The assembly is of a globular shape, with a grain size from 100 nanometers to 10 microns. The nanometer crystal has a shape of needle, silk or sheet, with a length of from 20nm to 800nm. A method for preparing the hydroxyapatite hybridized nanometer crystal assembly comprises the following steps of: (1) preparing a hyaluronic acid polysaccharide solution, (2) slowly scattering ions, and (3) collecting products and drying. The hydroxyapatite hybridized nanometer crystal assembly can be used as medical carrier, absorbent, filler, and the like.

Description

technical field [0001] The invention belongs to the field of hydroxyapatite composite materials, in particular to a hyaluronic acid-hydroxyapatite hybrid nanocrystal assembly and a preparation method thereof. Background technique [0002] Nanocrystal assemblies refer to crystals with advanced and complex structures assembled in a certain way through weak interactions between nanocrystals (Wang Dingsheng, Peng Qing, Li Yadong; Synthesis and assembly of monodisperse nanocrystals and preparation of mesoporous materials ; Chinese Science Series G: Physics, Mechanics and Astronomy; 2008, 38(11): 1434~1454). Due to the excellent properties of nanocrystalline assembly materials such as large specific surface area, they have received extensive attention and research in recent years (Wei Wei, Guang-Hui Ma, et al., Preparation of Hierarchical Hollow CaCO 3 Particles and the Application as Anticancer Drug Carrier, JACS, 2008, 130(47), 15808-15810). [0003] Hydroxyapatite is the mai...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B82B1/00B82B3/00A61K47/36A61K47/02B01J13/02B01J20/04
Inventor 李旭东王彩红陈震华陈君泽桑琳罗冬梅
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com