Porous bracket with micro grooves on pore walls and preparation method thereof

A technology of porous scaffolds and micro-grooves, applied in medical science, prosthesis, etc., can solve the problem of difficulty in constructing micro-grooves, and achieve the advantages of large-scale production, good reproducibility, and good adhesion of cells. attached effect

Inactive Publication Date: 2010-12-22
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] But these studies are often limited to building structures on two-dimensional materials
It is difficult

Method used

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  • Porous bracket with micro grooves on pore walls and preparation method thereof
  • Porous bracket with micro grooves on pore walls and preparation method thereof
  • Porous bracket with micro grooves on pore walls and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0033] Example 1

[0034] Firstly, sugar fibers with a diameter of 10 μm are spun by a commercially available electric wire drawing machine. The sodium chloride is sieved with molecular sieves to obtain different particle sizes, and sodium chloride with a particle size of 180 μm-280 μm is taken for later use. Dissolve 2g of PLGA85 / 15 with a molecular weight of 359,000 in 11g of dichloromethane, then disperse 1g of sugar fiber and 30g of sodium chloride in the dichloromethane solution of PLGA, pour it into the mold, press at room temperature, after 24 hours Decompression, take out the stent, soak the stent with 200ml deionized water, change the water every 1 hour, until the 0.1mol / L silver nitrate aqueous solution is added dropwise to the leaching solution, no white precipitation appears, indicating sugar fiber and chlorine Sodium sulfide has been completely leached, and the stent that has completely leached the porogen is used to absorb most of the deionized water with filter pap...

Example Embodiment

[0035] Example 2 Dissolve 2g of PLGA85 / 15 with a molecular weight of 359,000 in 11g of dichloromethane, and then disperse 5g of sugar fiber (diameter 10μm) and 26g of sodium chloride (particle size 180μm-280μm) evenly dispersed in the dichloride of PLGA Pour the methane solution into the mold, press at room temperature, decompress after 24 hours, use 200ml deionized water holder, change the water every 0.5 hours, until 0.1mol / L silver nitrate aqueous solution is added dropwise to the leaching solution. A white precipitate appears, indicating that the sugar fiber and sodium chloride have been completely leached. The stent that has completely leached the porogen is used to absorb most of the deionized water with filter paper or toilet paper, and then vacuum-dried at a drying temperature of 20°C and a drying time of 48 hours A three-dimensional porous scaffold with grooves on the pore wall with a pore diameter of 200 μm and a porosity of 90% is obtained. The groove is 10 μm wide an...

Example Embodiment

[0036] Example 3 2g of PLGA85 / 15 with a molecular weight of 359,000 was dissolved in 17g of dichloromethane, and then 1g of sugar fiber (diameter 15μm) and 20g of sodium chloride (particle size 180μm-280μm) were uniformly dispersed in the dichloride of PLGA Pour the methane solution into the mold, press at room temperature, decompress after 24 hours, take out the stent, soak the stent with 200ml deionized water, change the water every 1 hour, until the water solution of 0.1mol / L silver nitrate is used, drip When added to the leaching solution, there is no white precipitation, so far. The stent from which the porogen has been completely leached is used to absorb most of the deionized water with filter paper or toilet paper, and then vacuum-dried, vacuum-dried, at a temperature of 20°C, and dried for 48 hours to obtain a pore wall with a pore size of 200μm and a porosity of 86% A three-dimensional porous scaffold with 15μm wide and 15μm deep grooves has a theoretical coverage of ...

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Abstract

The invention belongs to the technical field of biological materials, and particularly relates to a porous bracket with micro grooves on pore walls and a preparation method thereof. The pore walls of the porous bracket are provided with micro grooves, the porosity is 20-99%, the pore size is 5-2000 mu m, the width of each micro groove is 20 nm -300 mu m, the depth of each micro groove is 20 nm-300 mu m, and the percentage of coverage of the micro grooves on the pore wall surface is 0.5-98%; and the substrate of the bracket is made of self-adhesive dissoluble high molecular material with plasticity. The preparation method comprises the following steps: evenly mixing fibrous substance, porogenic agent and substrate material in solvent, and carrying out die pressing/particle leaching at roomtemperature. The bracket is constructed with a unique micro groove structure in a three-dimensional space structure, and provides a new three-dimensional space for the response of cells and material.The three-dimensional porous bracket can be used as a carrier for cell adhesion and orientated growth.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a porous support with grooves on the inner surface (hole wall) and a preparation method thereof. Background technique [0002] Tissue engineering is a comprehensive application of the basic principles, basic theories, basic technologies and basic methods of engineering and life sciences. It pre-constructs a biologically active implant in vitro, and then implants it in the body to repair tissue defects and replace tissues and organs. Part or all of the functions, or as an extracorporeal device, temporarily replace part of the functions of organs to achieve the purpose of improving life, quality of life, and prolonging life activities. The core of this connotation is living cells, scaffolding materials for cells to carry out life activities, and the interaction between cells and scaffolding materials, which are the main scientific issues in tissue engineering resea...

Claims

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Application Information

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IPC IPC(8): A61L27/14A61L27/18A61L27/16A61L27/26A61L27/56C08J9/26
Inventor 丁建东屈泽华
Owner FUDAN UNIV
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