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Compound preparation for preventing and treating poultry liver diseases and preparation method thereof

A compound preparation and liver disease technology, which is applied in the field of compound preparation and its preparation for the prevention and treatment of poultry liver disease, can solve the problems of difficult storage and affecting feed storage, and achieve the effects of convenient administration, high drug utilization rate and long residence time

Inactive Publication Date: 2011-01-05
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the 98.5% betaine hydrochloride used in clinical practice is very hygroscopic, and it is not easy to store itself, and it will affect the storage of feed after mixing.

Method used

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  • Compound preparation for preventing and treating poultry liver diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Components:

[0025] components

Dosage

Silymarin

25% (W / V)

betaine

1.6% (W / V)

ethanol

3% (V / V)

sodium lauryl sulfate

0.06% (W / V)

Glycerol

10% (V / V)

sodium citrate

2% (W / V)

Propylparaben

0.03% (W / V)

purified water

add up to 100%

[0026] Preparation method:

[0027] (1) First dissolve sodium citrate into 27ml of purified water, then add silymarin, betaine, ethanol and sodium lauryl sulfate, and stir to obtain mixture A.

[0028] (2) Take 60ml of purified water, add propylparaben, heat to dissolve, place it at room temperature, add glycerol, and stir to obtain mixture B.

[0029] (3) Pour solution B into solution A, stir and mix evenly, and dilute to 100ml with purified water to obtain mixture C.

[0030] (4) The mixture C is homogenized by a high-pressure homogenizer under a pressure of 100Mpa, and a silymarin and betaine suspension with a particle size of 5nm-50...

Embodiment 2

[0032] Components:

[0033] components

Dosage

Silymarin

12.5% ​​(W / V)

betaine

0.8% (W / V)

ethanol

2.3% (V / V)

sodium lauryl sulfate

0.08% (W / V)

Sodium carboxymethyl cellulose

5% (W / V)

[0034] Glycerol

12% (V / V)

sodium citrate

2.5% (W / V)

Potassium sorbate

0.03% (W / V)

purified water

add up to 100%

[0035] Preparation method:

[0036] (1) Dissolve sodium citrate into 260ml of purified water first, then add silymarin, betaine, ethanol and sodium lauryl sulfate, and stir to obtain mixture A.

[0037] (2) Take 600ml of purified water, add potassium sorbate, stir to dissolve and place it at room temperature, then add sodium carboxymethylcellulose and glycerin, and stir to obtain mixture B.

[0038] (3) Pour mixture B into mixture A, stir and mix evenly, and dilute to 1 L with purified water to obtain mixture C.

[0039] (4) Mixture C was homogenized by a ...

Embodiment 3

[0041] Clinical Efficacy Trial

[0042] 1. Materials

[0043] The control drug was a premix, which was purchased from the market. The “Gan Shen Kang” produced by a company in Qingdao was mainly composed of silymarin, carboxydiphenylpropiperine, L-carnitine, taurine, indomethacin sodium, Composed of 17 herbs including angelica, atractylodes macrocephala, green peel, tangerine peel, magnolia bark, and cinnamon.

[0044] The experimental drug is the silymarin and betaine nanosuspension prepared in Example 1.

[0045] Experimental animals: Silky chickens from a broiler chicken farm in Shenxian County, Shandong Province.

[0046] 2. Method

[0047] A total of 90 commercial silky chickens with low feed intake, depression, rough feathers and fatty liver were selected and randomly divided into 3 groups, 30 in each group. The first group is the premix control drug group, and the diet that the chicken eats is that every 1000kg feed is mixed with the feed of 1kg premix, and is used c...

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Abstract

The invention relates to a compound preparation for preventing and treating poultry liver diseases and a preparation method thereof. The invention well solves the preparation stability problem of silymarin and betaine two medicaments which are effective for poultry liver diseases. The prepared product is nano suspension; and when diluted according to dosage, the product can disperse in water uniformly and keep a stable suspension state. In clinic use, the product has the characteristics of convenient medicament administration, high medicament utilization rate, long in-vivo detention time, no drinking trough blockage and the like. The Chinese and western compound preparation can conduct maximum treatment and health-care effects of eliminating free radicals, promoting liver cell generation, detoxifying and protecting liver.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and specifically provides a compound preparation for preventing and treating poultry liver diseases and a preparation method thereof. The main drug includes silymarin and betaine, and the compound preparation is a nano-suspension, which can be suspended in water and is stable. Background technique [0002] With the intensive and large-scale development of China's poultry industry, the breeding efficiency has been greatly improved, but it has also created conditions for large-scale outbreaks of epidemic and infectious diseases. Salmonella infection, Escherichia coli infection, etc., will cause liver damage in chickens; due to the high energy intake and rapid protein synthesis of laying hens, fatty liver is ubiquitous, especially in the late laying period. The liver is an important detoxification organ, and the damage of liver disease to poultry individuals is mainly manifested as low immunity, gro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/357A61K47/38A61K47/36A61K47/20A61K47/14A61K47/12A61P1/16A61K31/205
Inventor 刘桂兰
Owner TIANJIN RINGPU BIO TECH
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