Method for improving material blood compatibility by using electrostatic self-assembled coating

A blood-compatibility, electrostatic self-assembly technology, applied in the field of surface science and biomedical polymer materials, can solve the problems of difficult to obtain phosphorylcholine-rich surface, limited biocompatibility, limited application, etc. To achieve the effect of reducing platelet adhesion, improving blood compatibility, and strong adaptability
CN101934080AInactive Publication Date: 2011-01-05NORTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NORTHWEST UNIV
Publication Date
2011-01-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for improving material blood compatibility by using an electrostatic self-assembled coating. The method comprises that: polyanion dipolymer is adsorbed on the surface of a polycation material by electrostatic interaction, and a cell outer membrane simulating structure is formed on the surface of the polycation material. The binary copolymer of acrylic monomers containing amphoteric ions and negative ions is taken as polyanions, the polycations and the polyanions construct the cell outer membrane simulating structure on the surface of the polycation material by electrostatic self-assembly, and the polyanion dipolymer is adsorbed on the surface of the polycations by electrostatic interaction, so the method has simple condition and strong adaptability and can realize surface modification of the polycation material with a complex shape structure. Compared with the polycation material, the protein adhesion and platelet adherence of the modified surface are obviously reduced, and the blood compatibility is remarkably improved.
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Description

technical field

[0001] The invention relates to a method for improving blood compatibility of materials by using an electrostatic self-assembly coating, and belongs to the technical fields of surface science and biomedical polymer materials. Background technique

[0002] Gene therapy is considered to be an effective way to treat various genetic diseases (including infectious diseases, cancer, etc.). In the process of gene therapy, gene vectors (including viral vectors and non-viral vectors) must be used to deliver nucleic acid drugs to the lesion site. The former is a carrier with high transfection efficiency, but the immune response and gene mutation limit its application. Therefore, people are paying more and more attention to safe, low-toxic non-viral vectors, among which polycationic gene vectors are one of the research hotspots in recent years.

[0003] In practical applications, polycationic non-viral gene carriers also have certain problems. Specifically, the surfa...

Claims

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