Fluorocarbon film rubber plug and preparation method thereof

A technology of rubber stopper and fluorocarbon film, which is applied to the types of packaged items, special packaged items, packaging, etc. It can solve the problems of film layer shedding, reducing the self-sealing performance of rubber stoppers, and the difficulty of uniform film formation on the surface of rubber stoppers, etc.

Active Publication Date: 2011-01-26
郑州翱翔医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The film materials commonly used now include polytetrafluoroethylene, polyethylene, polypropylene, polychlorinated p-xylene, etc. The production process is complicated, the efficiency is low, and the cost is high. Due to the thickness of the film layer, it is easy to cause the film layer to fall off and reduce the rubber stopper. The original self-sealing property, and it is difficult to achieve uniform film formation on the surface of rubber stoppers with complex shapes

Method used

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  • Fluorocarbon film rubber plug and preparation method thereof
  • Fluorocarbon film rubber plug and preparation method thereof
  • Fluorocarbon film rubber plug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The fluorocarbon film rubber stopper in this embodiment includes a rubber stopper body, the surface of the rubber stopper body is entirely covered with a fluorocarbon polymer film, and the rubber stopper body and the fluorocarbon polymer film are integrated by physical and / or chemical bonding In one piece, there is no adhesive in between.

[0025] The content of carbon atoms in the fluorocarbon polymer film is 30-50%, and the content of fluorine atoms is 50-70%.

[0026] The thickness of the fluorocarbon polymer film is about 1 μm.

[0027] Manufacturing method of fluorocarbon membrane rubber stopper:

[0028] The surface of the common rubber stopper is cleaned and dried, then placed in the deposition chamber of the plasma enhanced chemical vapor deposition (PECVD) equipment and evacuated to 1??10 -1 Pa or less. When the deposition chamber temperature rises rapidly to 100 o After C, enter C with a flow rate of 50~100sccm 4 F 8 gas; adjust the air pressure of the ...

Embodiment 2

[0030] The fluorocarbon film rubber stopper in this embodiment includes a rubber stopper body, the surface of the rubber stopper body is entirely covered with a fluorocarbon polymer film, and the rubber stopper body and the fluorocarbon polymer film are integrated by physical and / or chemical bonding In one piece, there is no adhesive in between.

[0031] The content of carbon atoms in the fluorocarbon polymer film is 20-35%, the content of fluorine atoms is 35-55%, the content of hydrogen atoms is 10-15%, and the content of silicon atoms is 1-3%.

[0032] The thickness of the fluorocarbon polymer film is about 1 μm.

[0033] Manufacturing method of fluorocarbon polymer rubber stopper

[0034]The surface of the ordinary rubber stopper was cleaned and dried, then placed in the deposition chamber of the plasma-enhanced chemical vapor deposition (PECVD) equipment and evacuated to 1??10 -1 Pa or less. When the deposition chamber temperature rises rapidly to 170 o After C, firs...

Embodiment 3

[0036] The fluorocarbon membrane rubber stopper in this embodiment is as figure 1 As shown in the figure, including the rubber stopper body, the surface of the rubber stopper body is completely covered with a fluorocarbon polymer film, and the rubber stopper body and the fluorocarbon polymer film are integrated into one by physical and / or chemical bonding, and there is no glue between them. agent.

[0037] The content of carbon atoms in the fluorocarbon polymer film is 25-45%, the content of fluorine atoms is 45-60%, the content of oxygen atoms is 4-6%, and the content of nitrogen atoms is 1-3%.

[0038] The thickness of the fluorocarbon polymer film is about 0.5 μm.

[0039] Manufacturing method of fluorocarbon membrane rubber stopper:

[0040] A common rubber stopper was placed in the deposition chamber of an inductively coupled plasma chemical vapor deposition (ICP-CVD) equipment and evacuated to 1??10 -2 Below Pa, the flow rate of C is 50~65sccm 4 F 8 Gas and 5~15sccm...

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Abstract

The invention relates to a fluorocarbon film rubber plug and a preparation method thereof. The fluorocarbon film rubber plug comprises a rubber plug body, part or all of the surface of the rubber plug body is covered with a fluorocarbon polymer film, and the rubber plug body and the fluorocarbon polymer film are physically and / or chemically bonded and integrated into a whole without any adhesive between of both. The fluorocarbon polymer film is obtained by being deposited on the surface of an ordinary rubber plug by adopting a method of plasma chemical vapor deposition of reaction gas glow discharge. By strongly combining the ordinary rubber plug with the fluorocarbon polymer film with the advantages of high hydrophobicity, strong chemical inertness, uniform and compact structure and precise and controllable film thickness, the invention not only can obviously improve compatibility with contacted medicines, but also can effectively avoid the adhesion phenomenon of the rubber plug and easily remove surface contamination and preserve the original elasticity and tightness of the rubber plug in order to significantly improve product quality of the ordinary rubber plug and further expand application scope of the ordinary rubber plug.

Description

technical field [0001] The invention relates to the field of medical encapsulation materials, in particular to a medical fluorocarbon membrane rubber stopper and a preparation method thereof. Background technique [0002] Medical rubber stoppers are the main sealing parts and lead-out parts used to encapsulate various bottled medicines such as antibiotics and infusion medicines. During use and storage, they will inevitably come into direct contact with medicines, and their quality affects the stability of medicines. decisive role. Existing studies have shown that when the rubber stopper is in contact with the injection, the rubber stopper may absorb the active ingredients, antibacterial preservatives or other substances in the injection, and even chemical reactions may occur to cause the drug to fail; one or several components in the rubber stopper may occur. It may also be leached into the injection solution to make it turbid, produce toxicity or pyrogen, affect the chemic...

Claims

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Application Information

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IPC IPC(8): A61J1/14C08L27/12
Inventor 岳瑞峰
Owner 郑州翱翔医药科技股份有限公司
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