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Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof

A technology of metritis, Chinese and Western medicine, applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as unreasonable formulas, decreased curative effect of drug-resistant strains, and slow action effects , to achieve the effects of easy absorption for treatment, long-lasting drug effect, and improved utilization

Inactive Publication Date: 2012-05-02
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of metritis mainly adopts antibiotics, chemically synthesized antibacterial drugs, and traditional Chinese medicine. The use of antibiotics is quick, but it is easy to produce drug-resistant strains, which will reduce the curative effect, especially the waste of milk during antibiotic treatment will increase the treatment cost; chemically synthesized antibacterial Drugs have a strong killing effect on bacteria, but the function is relatively simple; traditional Chinese medicine is a natural drug, which has the advantages of no drug resistance and no residue, but the effect is slow
The medicines currently on the market for the treatment of cow metritis, due to the unreasonable formula, the treatment effect needs to be improved

Method used

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  • Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof
  • Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof
  • Compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 5g of turmeric, 5g of rhubarb, 10g of Phellodendron phellodendri, 5g of Angelica dahurica, 10g of Viola chinensis, 10g of honeysuckle, 5g of dandelion, 10g of Sagevine, 10g of Patrinia, 10g of forsythia, 0.2g of gatifloxacin, 0.05g of dexamethasone g, 0.5g of palmatine, measure 40ml of dimethyl sulfoxide, 10ml of glycerin; add turmeric, rhubarb, Phellodendron, Angelica dahurica, Viola chinensis, honeysuckle, dandelion, Sargentina, Patrinia, and Forsythia with water Decoct twice, each time for 2 hours, concentrate to contain 1g of Chinese medicinal materials per ml, add 95% ethanol until the alcohol content reaches 65%, let it stand for 12 hours, filter, add 95% ethanol to the filtrate to make the alcohol content reach 75% , stand still for 12 hours, filter, the filtrate volatilizes ethanol until it has no alcohol smell, and it is a traditional Chinese medicine extract; mix dimethyl sulfoxide and glycerin, add gatifloxacin, dexamethasone, palmatine, stir, add Chine...

Embodiment 2

[0017] Weigh 10g of turmeric, 10g of rhubarb, 10g of Cortex Phellodendri, 10g of Angelica dahurica, 10g of Viola, 5g of honeysuckle, 10g of dandelion, 5g of Rhizoma sagitta, 5g of Patrinia, 5g of forsythia, 1g of gatifloxacin, 0.5g of dexamethasone , 0.1g of palmatine, measure 40ml of dimethyl sulfoxide, 5ml of glycerin; add water to decoct turmeric, rhubarb, Phellodendron, Angelica dahurica, Viola chinensis, honeysuckle, dandelion, Sage rattan, Patrinia, and forsythia Boil twice, 2 hours each time, concentrate to 1g of Chinese herbal medicine per milliliter, add 95% ethanol until the alcohol content reaches 65%, let it stand for 12 hours, filter, add 95% ethanol to the filtrate to make the alcohol content reach 75%, Stand still for 12 hours, filter, the filtrate volatilizes ethanol until it has no alcohol smell, and it is a traditional Chinese medicine extract; mix dimethyl sulfoxide and glycerin, add gatifloxacin, dexamethasone, palmatine, stir, add Chinese medicine Add wate...

Embodiment 3

[0019] Weigh 20g of turmeric, 20g of rhubarb, 20g of Cortex Phellodendri, 5g of Angelica dahurica, 5g of Zihuadi Ding, 5g of honeysuckle, 5g of dandelion, 5g of Sagevine, 5g of Patrinia, 5g of Forsythia, 0.1g of gatifloxacin, and 0.01g of dexamethasone. g, 0.1g of palmatine, measure 10ml of dimethyl sulfoxide, 20ml of glycerol; add turmeric, rhubarb, Phellodendron, Angelica dahurica, Viola chinensis, honeysuckle, dandelion, Sargentina, Patrinia, and Forsythia with water Decoct twice, 2 hours each time, concentrate to 1g of Chinese medicinal materials per ml, add 95% ethanol until the alcohol content reaches 65%, let it stand for 12 hours, filter, add 95% ethanol to the filtrate to make the alcohol content reach 75% , stand still for 12 hours, filter, the filtrate volatilizes ethanol until it has no alcohol smell, and it is a traditional Chinese medicine extract; mix dimethyl sulfoxide and glycerin, add gatifloxacin, dexamethasone, palmatine, stir, add Chinese medicine extract,...

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Abstract

The invention discloses a compound infusion preparation of Chinese herbal medicines and western medicines for treating cow hysteritis and a preparation method thereof, belonging to the veterinary drug technology. The compound infusion preparation of the invention comprises turmeric, Chinese rhubarbs, amur corktree barks, angelica roots, philippine violet herbs, honeysuckle flowers, mongolian dandelion herbs, sargent gloryvine, dahurian patrinia herbs, weeping forsythiae capsule, Gatifloxacin, dexamethasone, Fibriuretinin, dimethyl sulfoxide, glycerol and water for injection, and the total volume is 100ml; and the preparation method comprises the following steps: adding water into the turmeric, the Chinese rhubarbs, the amur corktree barks, the angelica roots, the philippine violet herbs, the honeysuckle flowers, the mongolian dandelion herbs, the sargent gloryvine, the dahurian patrinia herbs and the weeping forsythiae capsule to decoct; concentrating the obtained liquid; adding ethanol into the obtained concentrated solution; standing and filtrating the obtained mixture; then obtaining a Chinese herbal extract after ethanol therein is completely volatilized and has no ethanol flavor exists; blending the dimethyl sulfoxide and the glycerol in the Gatifloxacin, the dexamethasone and the Fibriuretinin; stirring the obtained mixture; then adding the Chinese herbal extract into the obtained mixture; adding the water for injection until the total volume of the obtained product is 100ml; carrying out stirring, dissolving, standing, microfiltration-membrane filtration and sub-packaging on the obtained product; and finally, carrying out moist heat sterilization on the obtained product for 20 minutes at a temperature of 121 DEG C so as to obtain the compound infusion preparation of the invention. The invention has the advantages of wide antimicrobial spectrum, rapid effect taking, and lasting drug effect.

Description

technical field [0001] The invention belongs to the technology of veterinary medicine, and mainly relates to a Chinese and western medicine compound perfusion agent for treating bovine metritis and a preparation method thereof. Background technique [0002] Metritis is a relatively common obstetrical disease in dairy cows, which can prolong the calving interval, reduce milk production, increase treatment costs, increase the culling rate due to loss of reproductive ability, and cause great economic losses. Bacteria are the main pathogens causing metritis, the common pathogens are Escherichia coli, Staphylococcus aureus, followed by Streptococcus, Actinomyces pyogenes, Pseudomonas, Proteus, Corynebacterium, Bacillus and Cree Burgeria. The main symptoms of clinical examination are thickening of the uterine horns, thickening of the uterine wall, a large amount of dirty or brownish-yellow mucopurulent discharge from the vagina, and a large amount of exudate accumulated in the ut...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/08A61K47/20A61P15/00A61P31/04A61K31/573A61K31/4375A61K31/496
Inventor 岳奎忠张翔徐志辉
Owner NORTHEAST AGRICULTURAL UNIVERSITY