Preparation method of chrysoeriol

Abstract

The invention provides a preparation method of chrysoeriol. A high-purity chrysoeriol product is obtained by the steps of alkali extraction and water precipitation, organic solvent extraction, membrane concentration, macroporous resin adsorption, and the like. In a membrane separation process, not only the product purity is improved, but also the damage to resin is alleviated, and the service life of the resin is prolonged; and by adopting crystallization and recrystallization, the purification efficiency is high. The whole preparation process has the advantages that requirements on environment and equipment are low, extraction and separation time is short, purity is high and the preparation method is simple and easy to operate.

Description

Technical field:

[0001] The invention belongs to the field of medicine and chemical industry, and relates to a preparation method of coelisol. Background technique:

[0002] Coelisu

[0003] English name: Chrysoeriol, molecular formula: C 16 H 12 O 6 ; Molecular weight: 300.26;

[0004] Molecular structural formula:

[0005]

[0006] Coelitin is a pale yellow powder, mp. 320-322°C (mp. 336-337°C is also reported). Soluble in chloroform, ethyl acetate and other organic solvents.

[0007] Medicinal effects: anti-tumor (inhibits the carcinogenic effect of 3,4-benzopyrene, inhibits the metabolism of benzopyrene); cytotoxicity (P388, ED 50 =1.9 μg / ml); cAMP phosphodiesterase inhibitor (in vitro, IC 50 = 269 μmol / L); anti-allergic and anti-inflammatory (inhibit basophils to release histamine, inhibit neutrophils to release β-glucuronidase); aldose reductase inhibitor (10 μmol / L inhibition rate 31.3%); xanthine Oxidase inhibitor (50μg / ml inhibition rate 61.5%, IC 50 = ...

Images