Method for extracting forsythin from weeping forsythia leaves

A technology for forsythin and forsythia leaves, which is applied in the field of plant extraction, can solve the problems of excessive heavy metals, many types of organic reagents, low content, etc., and achieves the effects of simple operation, good impurity removal effect, and reduced production cost.

Inactive Publication Date: 2011-02-16
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] As mentioned above, the existing process has excessive or low content of heavy metals or many types of organic reagents

Method used

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  • Method for extracting forsythin from weeping forsythia leaves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Forsythia leaves were sorted and crushed, put 5kg into a small extraction tank, added 60Lph10 saturated lime water and heated to 50°C, stirred and extracted for 1 hour, extracted 3 times, the combined extract was kept at 8°C, filtered and adjusted to neutralize with hydrochloric acid, Add 3LHZ801 macroporous resin column for adsorption, the column flow rate is 3L / h, wash the impurities with 30L water first, and then use 15L80% ethanol solution to elute forsythin, the elution rate is 9L / h. , Collect the eluate to recover ethanol, place the crystals, and filter to obtain crude crystals. Dissolve the crude crystals with 99% ethanol in a short and thick column of aluminum peroxide (120-200 mesh neutral alumina 800g, diameter-to-height ratio 1:3), and recover the ethanol under reduced pressure to 1 / 5 volume crystallization of the injection solution to obtain two Secondary crystals. The secondary crystals were refluxed with 95% ethanol to dissolve the crystals at room temper...

Embodiment 2

[0033] Forsythia leaves were sorted and crushed, put 5kg into a small extraction tank, added 40Lph9 saturated lime water and heated to 7°C, stirred and extracted for 2 hours, extracted 3 times, combined extracts were kept at 100°C and filtered to neutralize with sulfuric acid, Add 4L D4020 macroporous resin column for adsorption, the column flow rate is 8L / h, wash the impurities with 40L water first, and then use 32L 50% ethanol solution to elute forsythin, the elution rate is 4L / h. , Collect the eluate to recover ethanol, place the crystals, and filter to obtain crude crystals. Dissolve the crude crystals with 95% ethanol in a short and thick column of aluminum peroxide (120-200 mesh neutral alumina 800g, diameter-to-height ratio 1:3), and recover the ethanol under reduced pressure to 1 / 3 volume crystallization of the injection solution to obtain two Secondary crystals. The secondary crystals were refluxed with 99% ethanol to dissolve the crystals at room temperature twice, ...

Embodiment 3

[0035] Forsythia leaves were sorted and crushed, put 5kg into a small extraction tank, added 75Lph10 saturated lime water and heated to 60°C, stirred and extracted for 2 hours, extracted twice, and the combined extracts were kept at 8°C and filtered to neutralize the phosphoric acid mediation. Add 3L X-5 macroporous resin column for adsorption, the column flow rate is 6L / h, wash the impurities with 30L water first, and then use 21L 60% ethanol solution to elute forsythin, the elution rate is 3L / h. , Collect the eluate to recover ethanol, place the crystals, and filter to obtain crude crystals. Dissolve the crude crystals with 95% ethanol in a short thick column of aluminum peroxide (700 g of 120-200 mesh neutral alumina, diameter-to-height ratio 1:2), and recover the ethanol under reduced pressure to 1 / 5 volume crystallization of the injection liquid to obtain two Secondary crystals. The secondary crystals were refluxed with 95% ethanol to dissolve the crystals at room temper...

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Abstract

The invention relates to a method for extracting forsythin from weeping forsythia leaves. The method comprises the following steps of: smashing the weeping forsythia leaves serving as raw materials; adding solution of calcium hydroxide in an amount of 6 to 15 times that of the raw materials; heating until the temperature is between 50 and 70 DEG C; dynamically extracting for 1 to 3 hours for 2 to 3 times; preserving the heat of extracting solution at the temperature of between 80 and 1 DEG C; adjusting the extracting solution to neutral state; filtering and adding a macro-porous resin column for adsorbing; eluting impurities with water; eluting the forsythin with 50 to 80 percent solution of ethanol; condensing and crystallizing; dissolving an alumina short column with ethanol; recrystallizing and the like so as to obtain the forsythin. The forsythin produced by the method has high content and low cost and can be directly taken as a raw material for a health-care medicament. The method is easy to industrialize.

Description

Technical field: [0001] The invention belongs to the technical field of plant extraction, in particular to a method for extracting forsythin from forsythia leaves. Background technique: [0002] Forsythia is one of the traditional Chinese medicines commonly used in clinical practice in China, also known as Huanghuatiao, Lianhu, Qingqiao, Luoqiao, Huangqidan, etc. The forsythia recorded in the 2005 edition of the Pharmacopoeia of the People's Republic of China is the dried fruit of Forsythia genus Forsythia in Oleaceae. For the old Alice. [0003] Forsythia has antibacterial, cardiotonic, diuretic, anti-emetic and other pharmacological effects. It is used for wind-heat cold, fever, upset, sore throat, macule, erysipelas, scrofula, carbuncle sores, acute nephritis, and stranguria. [0004] Forsythin is a lignin glycoside compound, molecular formula: C27H34O11, molecular weight: 534, [0005] [0006] Physical properties: Melting point 1°C, hardly soluble in water, solubl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H15/26
Inventor 苏刘花
Owner NANJING ZELANG AGRI DEV
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