Unlock instant, AI-driven research and patent intelligence for your innovation.

Stable chlorine dioxide sustained-release gel preparation and preparation method and application thereof

A chlorine dioxide gel and chlorine dioxide technology, applied in the new application of preparations for rapid hemostasis, in the field of preparation preparation, can solve problems such as application research limitations

Active Publication Date: 2011-04-06
毕小平
View PDF4 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the stability factor of chlorine dioxide itself, the application research is also limited to a certain extent. The key factor is to solve the problem of the stability of chlorine dioxide, in order to be able to play a stable, effective, safe and long-lasting role and apply it clinically.
Existing chlorine dioxide and its preparations are mostly used in water treatment, air purification, etc., and there are no relevant reports on rapid hemostasis in humans and animals.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Stable chlorine dioxide sustained-release gel preparation and preparation method and application thereof
  • Stable chlorine dioxide sustained-release gel preparation and preparation method and application thereof
  • Stable chlorine dioxide sustained-release gel preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] ①Based on 100 parts by weight, weigh 10 parts of carboxymethylcellulose sodium, and evenly disperse it in 90 parts of 18-25mg / ml stable chlorine dioxide solution. Stir evenly to obtain the stable chlorine dioxide gel A system;

[0019] ②Based on 100 parts by weight, take 20 parts of Carbomer 940, and evenly disperse it in 70 parts of acetic acid solution with a pH of 2.6-3.5. After fully swelling, add 10 parts of glycerin under stirring condition of 400-650r / min, Mix evenly to get the activated gel B system;

[0020] ③Before use, mix system A and system B uniformly at a ratio of 1:0.8 to form a stable chlorine dioxide slow-release gel.

[0021] This product uses a drug transdermal absorption device for in vitro release simulation test. Dialysis membrane radius D=21mm, molecular weight cut-off is 12000-14000Da. Under the condition of temperature of 37±0.5°C, take the liquid at 1, 2, 4, 6, 8, 10, 11, 12, and 24 hours for measurement, according to "Pharmacopoeia of the ...

Embodiment 2

[0024] ①Based on 100 parts by weight, weigh 20 parts of sodium carboxymethylcellulose and 5 parts of sodium alginate, and evenly disperse them in 75 parts of stable chlorine dioxide solution of 18-25mg / ml. Under the condition of -650r / min, stir evenly to obtain the stable chlorine dioxide gel A system;

[0025] ②Based on 100 parts by weight, take 15 parts of Carbomer 940 and evenly disperse them into 77 parts of acetic acid solution with a pH of 2.6-3.5. After fully swelling, add 8 parts of glycerin under the stirring condition of 400-650r / min, Mix evenly to get the activated gel B system;

[0026] ③Before use, mix system A and system B uniformly at a ratio of 1:1.5 to form a stable chlorine dioxide slow-release gel.

[0027] This product uses a drug transdermal absorption device for in vitro release simulation tests. Dialysis membrane radius D=21mm, molecular weight cut-off is 12000-14000Da. Under the condition of temperature of 37±0.5°C, take the liquid at 1, 2, 4, 6, 8, ...

Embodiment 3

[0030]①Based on 100 parts by weight, weigh 20 parts of sodium carboxymethylcellulose and 10 parts of sodium alginate, and evenly disperse them in 70 parts of 18-25mg / ml stable chlorine dioxide solution. Under the condition of -650r / min, stir evenly to obtain the stable chlorine dioxide gel A system;

[0031] ②Based on 100 parts by weight, take 20 parts of Carbomer 940, and evenly disperse it in 70 parts of acetic acid solution with a pH of 2.6-3.5. After fully swelling, add 10 parts of glycerin under stirring condition of 400-650r / min, Mix evenly to get the activated gel B system;

[0032] ③Before use, mix system A and system B uniformly at a ratio of 1:1 to form a stable chlorine dioxide slow-release gel.

[0033] This product uses a drug transdermal absorption device for in vitro release simulation tests. Dialysis membrane radius D=21mm, molecular weight cut-off is 12000-14000Da. Under the condition of temperature of 37±0.5°C, take the liquid at 1, 2, 4, 6, 8, 10, 11, 12,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a chlorine dioxide sustained-release gel preparation, a preparation method and application thereof to rapid stop of at human or animal bleeding from wounds. The chlorine dioxide sustained-release gel preparation consists of a stable chlorine dioxide gel system A and an activated gel system B, wherein the stable chlorine dioxide gel system A and the activated gel system B are uniformly mixed according to the weight ratio of 1:0.8-1:1.5; the stable chlorine dioxide gel system A, based on a total weight of 100 parts, consists of the following substances: 70 to 90 parts of stable solution of chlorine dioxide, 10 to 30 parts of sodium carboxymethylcellulose and 0 to 10 parts of sodium alga acid; and the activated gel system B consists of the following substances: 10 to 25 parts of Carbomer 940, 5 to 15 parts of glycerol and 60 to 80 parts of solution of acetic acid with the pH value of 2.6 to 3.5. The preparation is prepared by using a binary form, and the two systems are uniformly mixed according to the ratio in clinic. The preparation technology is simple, the cost is low, and the effect of rapidly stopping bleeding can be achieved.

Description

technical field [0001] The invention relates to a stable chlorine dioxide sustained-release gel preparation, a preparation method of the preparation, and a new application of the preparation for rapid hemostasis. Background technique [0002] Chlorine dioxide is a safe, efficient, broad-spectrum, and powerful bactericide recognized by the United Nations World Health Organization. Its bactericidal ability is 5 times that of chlorine. It has a good killing and inhibiting effect on bacteria and viruses. It is used for water treatment. , does not react with organic matter in the water body to generate carcinogens such as trihalomethanes, and low doses of chlorine dioxide also have a strong anthelmintic effect. And the oral toxicity test shows that chlorine dioxide is a non-toxic product, safe to use, and it has no carcinogenic, teratogenic, mutagenic effects on higher animal and plant cells. It is widely used in water treatment, papermaking, bleaching, disinfection of medical a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K33/40A61K47/38A61L15/44A61P7/04
Inventor 毕小平李娟赵正保胡超云白冰谢茵全红金伟
Owner 毕小平