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Method for preparing inorganic/organic composite microspheres

A composite microsphere and organic technology, applied in the field of composite materials, can solve the problems of nanoparticle leakage and achieve the effects of good repeatability, uniform distribution and simple preparation process

Active Publication Date: 2011-04-13
南通药享科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an accurate and efficient method for preparing inorganic / organic composite microspheres, focusing on solving the bottleneck problem of nanoparticle leakage in the composite microspheres, and further expanding the coded microspheres for multiple biological analysis in the field of biomedicine , the application of the filter

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  • Method for preparing inorganic/organic composite microspheres
  • Method for preparing inorganic/organic composite microspheres
  • Method for preparing inorganic/organic composite microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1, weighing 30 mg of mesoporous polystyrene microspheres with an average particle size of 15 μm and a degree of crosslinking of 100%, such as figure 1 As shown; Measure 100 μL of CdSeTe quantum dots with an emission wavelength of 588nm; add the weighed microspheres into 6mL of hexadecane, and disperse evenly by ultrasonic; add the weighed quantum dots into 3mL of chloroform, and disperse evenly by ultrasonic ; Mix the two systems evenly and add them to a three-necked flask; install the air condensation device, ventilation device, and heating device; use a heating pot to raise the temperature, and keep the temperature at 50°C for 90 minutes;

[0029] Step 2, heating the reaction system to 180°C;

[0030] Step 3: observe that there is no reflux of chloroform, keep warm for 10 minutes, remove the heating device, rapidly cool down, and centrifuge and wash 4 times to obtain fluorescent microspheres.

[0031] Such as figure 2 , is the fluorescence spectrum of the quan...

Embodiment 2

[0033] Step 1, take 5 mg of polymethyl methacrylate microspheres with an average particle size of 1 μm and a crosslinking degree of 5% and 20 μL of CdSe quantum dots with an emission wavelength of 541 nm, and add the weighed microspheres to 3 mL of hexadecane, Ultrasonic dispersion is uniform; add the measured quantum dots to 1mL of cyclohexane, and ultrasonic dispersion is uniform; mix the two systems evenly and add them to a three-necked flask; install the air condensation device, ventilation device, and heating device; Use a heating pot to raise the temperature, and keep it warm at 60°C for 30 minutes; Step 2, raise the temperature of the reaction system to 140°C;

[0034] Step 3: observe without cyclohexane reflux, keep warm for 10 minutes, remove the heating device, rapidly cool down, centrifuge and wash 4 times to obtain fluorescent microspheres. Such as Figure 4 As shown, the fluorescent emission peak position of the prepared quantum dot fluorescent microspheres is at...

Embodiment 3

[0036] Step 1, take 20 mg of polyethyl methacrylate microspheres with an average particle size of 10 μm and a crosslinking degree of 20% and 60 μL of CdSe / ZnS quantum dots with an emission wavelength of 650 nm, and add the weighed microspheres to 6 mL of octadecane In olefin, the ultrasonic dispersion is uniform; the measured quantum dots are added to 4mL of cyclohexane, and the ultrasonic dispersion is uniform; the two systems are mixed evenly and then added to a three-necked flask; the air condensing device, ventilation device, and Heating device; use a heating pot to raise the temperature and keep it warm at 60°C for 60 minutes;

[0037] Step 2, heating the reaction system to 140°C;

[0038] Step 3: observe without cyclohexane reflux, keep warm for 10 minutes, remove the heating device, rapidly cool down, centrifuge and wash 4 times to obtain fluorescent microspheres. Such as Figure 5 As shown, the fluorescent emission peak position of the prepared quantum dot fluorescent ...

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Abstract

The invention relates to a method for preparing inorganic / organic composite microspheres. The method comprises the following steps of: dispersing inorganic nanoparticles and polymer microspheres in a sweller and a dispersing agent; swelling at the temperature of between 40 and 60 DEG C for 30 to 120 minutes; heating a reaction system to the temperature of between 140 and 240 DEG C, and keeping the temperature until the sweller does not reflux; and after the sweller is volatilized completely, cooling the reaction system quickly, centrifuging, washing and drying to obtain the inorganic / organic composite microspheres. By the method, the problem that the nanoparticles leak from the microspheres is solved to a great extent, so that the composite microspheres have high stability. Simultaneously, the effective utilization rate of the nanoparticles is improved; the capacity of the nanoparticles in the microspheres is increased; the preparation process is simple; and the repeatability is high. The nanoparticles are distributed uniformly; moreover, the signal strength of coding can be better controlled by controlling the quantity of the nanoparticles entering the microspheres.

Description

technical field [0001] The invention relates to a composite material applicable to the field of biomedicine, in particular to a method for preparing inorganic / organic composite microspheres through a high-temperature swelling method. Background technique [0002] In recent years, biomedical research has made remarkable achievements in functional gene analysis, drug screening and clinical diagnosis. At the same time, with the rapid development of combinatorial chemistry, natural product chemistry, and genomics, a large number of compounds to be screened and analyzed continue to emerge. How to efficiently and quickly screen out target substances from large-scale and complex candidate systems of biologically related substances to promote the development of biomedical research is a huge challenge for bioanalytical technologies at present. [0003] Suspension array technology (Suspension array technology) developed on the basis of the OBOC (One-Bead-One-Compound) screening techn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
Inventor 常津刘俊庆宋涛李云红张琦
Owner 南通药享科技有限公司
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