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Application of Fasudil in preparing medicaments for treating glaucoma through ophthalmic drug delivery

A technology for fasudil and glaucoma, applied in the field of medicine, can solve the problem of no safe and effective alternative drugs of the same kind, and achieve the effects of low toxic and side effects, prolonged residence time, and strong optical activity

Active Publication Date: 2011-04-27
TIANJIN CHASE SUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Commonly used glaucoma drugs have different degrees of adverse reactions, but there is currently no safe and effective alternative drug of the same kind

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Eye drops

[0028] Prescription (1000 pieces)

[0029] Fasudil Hydrochloride 10.0g

[0030] Sodium chloride 50.0g

[0031] Methyl p-hydroxybenzoate 1g

[0032] Propyl p-hydroxybenzoate 1g

[0033] 1,2-Propanediol 1g

[0034] Vitamin E 0.5g

[0035] EDTA-2Na 0.5g

[0036] Lactic acid

[0037] Add water for injection to 5000ml

[0038] Made into 1000

[0039] Preparation Process

[0040] Weigh fasudil hydrochloride in an appropriate amount of distilled water, stir and heat to dissolve; also take sodium chloride, EDTA-2Na, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, 1,2-propanediol and vitamin E Dissolve in a proper amount of boiling distilled water, stir to dissolve; combine the two liquids, add activated carbon (0.1%), heat at 60~80℃ for 15 minutes, filter and decarbonize, dilute with water for injection to the prepared amount, use 1mol / L lactic acid solution Adjust the pH value to 6.5±0.5, test the intermediate, filter through a 0.45μm microporous membrane after passing the tes...

Embodiment 2

[0042] Application of fasudil in preparing medicine for treating glaucoma

[0043] Reagents and instruments 0.1%, 0.5%, 1%, 5%, 10% concentration of fasudil (Tianjin Hongri Pharmaceutical Co., Ltd.), physiological saline (0.9% NaCl). Medtronic type electrophysiological instrument, CH type optical microscope. Tonometer: schiφtz indentation tonometer.

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Abstract

The invention relates to the application of Fasudil in preparing medicaments for treating glaucoma through ophthalmic drug delivery, which belongs to the technical field of medicines. The Fasudil comprises pharmaceutically acceptable saline forms such as hydrochloride, nitrate, sulfate, phosphate, hydrobromide, mesylate, citrate and the like as well as pharmaceutically acceptable forms such as crystallization form, hydrate form and the like. The medicament is a pharmaceutic preparation composition prepared by using the Fasudil as an active pharmaceutical ingredient.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of fasudil through ocular administration in the preparation of drugs for treating glaucoma. Background technique [0002] Glaucoma is a common and difficult eye disease with rapid onset, great harm, and blindness at any time. The characteristic is that the intermittent or continuous increase in intraocular pressure exceeds the tolerance of the eyeball, which damages all parts of the eyeball and visual function, resulting in optic nerve atrophy, visual field reduction, vision loss, and blindness is only a matter of time. , In the acute period of 24 to 48 hours can be completely blind. For this group of diseases, people have been actively seeking effective treatment drugs. Treatment methods for glaucoma include surgery and medication. The high risk of surgery and numerous complications discourage patients. At present, medication is the mainstay. Although ...

Claims

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Application Information

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IPC IPC(8): A61K31/551A61K9/08A61K47/22A61P27/06
Inventor 姚小青孙长海董凯王瑞卿
Owner TIANJIN CHASE SUN PHARM CO LTD
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