Medicine composite for treating dysmenorrhea, preparation method and detection method

The technology of a composition and a medicine is applied in the field of pharmaceutical composition for treating dysmenorrhea and its preparation and detection, and can solve the problems of organ disease, obvious side effects, drug resistance and addiction of the body and the like

Active Publication Date: 2011-04-27
北京富国堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the current treatment of dysmenorrhea mostly uses western medicines such as analgesics. Long-term monthly medication will not only easily caus

Method used

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  • Medicine composite for treating dysmenorrhea, preparation method and detection method
  • Medicine composite for treating dysmenorrhea, preparation method and detection method
  • Medicine composite for treating dysmenorrhea, preparation method and detection method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 2

[0060] Experimental Example 2 Writhing Reaction Experiment of Mice Induced by Glacial Acetic Acid

[0061] Get 50 healthy mice with a body weight of 18-22g, and randomly divide them into 3 groups. Group A is subcutaneously injected with normal saline 0.1ml / 10g; Group B is fed with Tongjingbao granule 0.15ml / 10g; 0.15ml / 10g (1ml contains 5g of the original drug); 0.1ml / 10g of 0.7% glacial acetic acid was injected intraperitoneally after subcutaneous administration for 15 minutes and gavage for 20 minutes. Observe and record the number of times the mice writhe within 20 minutes, and the results are shown in Table 2:

[0062] Table 2 Inhibition of writhing response in mice

[0063]

[0064] Note: P<0.01 between blank group A and groups B and C, and P<0.05 between group B and group C.

[0065] The results show that: compared with Tongjingbao granule, the pharmaceutical composition granule of the present invention has a significant effect of inhibiting the writhing reaction ca...

experiment example 3

[0066] Experimental Example 3 Effects on Rat Uterus in Vivo

[0067] Take 20 healthy non-pregnant female rats and divide them into two groups. Before the experiment, inject diethylstilbestrol subcutaneously at 0.2mg / 100g, once a day. After 3 days of injection, intraperitoneally anesthetize with pentobarbital sodium, and lie supine on the experiment table for laparotomy. , find one side of the uterine horn, suture the vaginal end and ovarian end of the uterine horn to the fulcrums at the bottom of the special fixed cover, sew a thin thread in the middle of the uterine horn, connect the traction line to the sensor through a pulley, and then sew the abdominal wall Suture around the bottom of the fixed hood, and close the abdominal cavity to record the experimental process through the MS-302 multimedia biological signal recording and analysis system.

[0068] Get above-mentioned rat and inject Rockwell nutrient solution 10ml into peritoneal cavity, tracing normal contraction curve...

experiment example 4

[0072] Experimental example 4 Effect of drugs on isolated uterine smooth muscle under the action of PGF2a analogs or oxytocin

[0073] Select 40 healthy non-pregnant female rats and divide them into 5 groups. Diethylstilbestrol was subcutaneously injected with 0.2mg / 100g before the experiment, once a day. Place it in a small tank filled with 30ml Rockwell solution, connect it to the sensor, keep it in a water bath at (36±0.5)°C, let oxygen flow into the tank from the ventilation hook, and record it with the MS-302 multimedia biological signal recording and analysis system Normal contraction curve, then add cloprostenol (PGF 2a Analogue) 5ug / 0.5ml or oxytocin injection 0.5ug / 5ml, make the uterine smooth muscle contract strongly, add pharmaceutical composition granule 0.6ml of the present invention and Tongjingbao granule 0.6ml after stabilization, observe and record 10min uterine The tension and frequency of smooth muscle contraction, the results are shown in Tables 4 and 5: ...

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Abstract

The invention discloses a medicine composite for treating dysmenorrhea, a preparation method and a detection method. The medicine composite comprises the following raw material drugs: salvia, red peony roots, cyperus rotundus, roses, typha orientalis, rhizoma corydalis (processed with vinegar), trogopteroum faeces, cassia twigs, peach kernels and radix auckandiae. The preparation method comprises the following steps of adding conventional adjuncts in the raw material drugs of the composite, and preparing clinically acceptable dosage forms including, but not limited to, a condensed pill, a capsule, a dropping pill, granules, a tablet, a soft capsule, a sustained release preparation retarder, an oral liquid preparation or a freeze-dried injection. In the invention, a high-efficiency liquid phase chromatography is adopted to determine the content of paeoniflorin. The medicine composite is used for treating the dysmenorrhea and has good curative effect.

Description

[0001] The present invention is a divisional application, the original application number is 200710064062.9, the original application date is February 26, 2007, and the original application name is: a pharmaceutical composition for treating dysmenorrhea, a preparation method and a quality control method. field of invention [0002] The invention relates to a pharmaceutical composition, a preparation method and a quality control method, in particular to a pharmaceutical composition for treating dysmenorrhea, a preparation method and a quality control method. Background technique [0003] Dysmenorrhea refers to pain in the lower abdomen or lower back of a woman, even reaching the lumbosacral area, before and after menstruation. It often occurs with the menstrual cycle. In severe cases, it may be accompanied by nausea and vomiting, dripping cold sweat, cold hands and feet, and even fainting, which will seriously affect work and life. At present, it is often divided into primary...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P15/00A61P29/00G01N30/90G01N30/02G01N21/82A61K35/24
Inventor 付立家付建家
Owner 北京富国堂医药科技有限公司
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