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Percutaneous absorption biological patch for treating rheumatoid arthritis and preparing method thereof

A technology for rheumatoid arthritis and arthritis, applied in the field of pharmaceutical preparations, can solve the problems of no preparation method and no biological patch, and achieve the effects of avoiding toxicity, simple preparation method and low investment

Inactive Publication Date: 2011-06-08
FUJIAN ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many research reports and patents about the patch, but there is no biological patch specifically for triptolide and lidocaine, so there is no preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] The transdermal biopatch for treating rheumatoid arthritis is composed of the main drug for treating rheumatoid arthritis, drug solvent, adhesive, biopatch matrix and transdermal absorption enhancer, and the main drugs are triptolide and Analgesic lidocaine hydrochloride for the relief of rheumatoid arthritis pain.

[0020] The drug solvent is selected from one or two or more of monohydric alcohols, dihydric alcohols, trihydric alcohols, and esters.

[0021] The pharmaceutical solvent is one or two of ethanol, propylene glycol, glycerin, 1,2 propylene glycol, polyethylene glycol, isopropanol, 2-octyldodecanol, pyrrolidone, and N-methyl-2-pyrrolidone.

[0022] Adhesive and bio-patch matrix are polyvinyl alcohol PVA-124, polyvinyl alcohol PVA-1788, polyvinyl alcohol PVA-0588, PVA-1750, polyethylpyrrolidone, CMC-Na, HPMC, lanolin, white petrolatum, kaolin , polyethylene glycol PEG-400, gelatin, carbomer-940, sodium polyacrylate, silicone rubber, zein gluten, polyvinyl but...

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PUM

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Abstract

The invention relates to a percutaneous absorption biological patch for treating rheumatoid arthritis and preparing method thereof. The biological patch consists of basic remedy treating for the rheumatoid arthritis, medicament solvent, adhesive, biological plaster matrix and percutaneous absorption penetration enhancer. The basic remedies treating for the rheumatoid arthritis include triptolide and analgesics lidocaine hydrochloride alleviating the pain of the rheumatoid arthritis. The biological plaster has comprehensive pharmacological effect, exactly blocks up the main pathology link of development of rheumatoid arthritis, has strong pertinency and lasting pharmacological effect; and can be prepared by using a general method in biological plaster preparing technology field; and the preparing method is simple.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations and a preparation method, in particular to a transdermal absorption biological patch for treating rheumatoid arthritis and providing local analgesia and a preparation method thereof. Background technique [0002] Triptolide is a chemical component extracted from Tripterygium wilfordii of the Euonymus family. From the point of view of pharmacological effects: (1) Triptolide has both non-specific anti-inflammatory and immune effects, and mainly suppresses immune effects. (2) It has obvious inhibitory effect on acute and chronic inflammation, and is related to the pituitary system, mainly through the pituitary gland to cause the release of ACTH and enhance the secretion function of the adrenal cortex. (3) The research on adjuvant arthritis shows that it has obvious inhibitory effect on adjuvant arthritis in rats. Rat adjuvant arthritis is an animal model for studying rheumatoid drugs, and ...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/167A61K9/70A61P19/02A61P29/00
Inventor 林绥彭华毅邓思珊黄郑隽阙慧卿钱丽萍连建清郭舜民齐一萍
Owner FUJIAN ACAD OF MEDICAL SCI
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