Double-magnetic-response temperature-sensitive microcapsules and preparation method thereof

A magnetic response, microcapsule technology, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problem that microcapsules cannot respond to multiple stimuli at the same time

Inactive Publication Date: 2011-07-20
PUTIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first purpose of the present invention is to provide a dual magnetic response temperature-sensitive microcapsule to solve the problem that the microcapsules in the prior art cannot respond to multiple stimuli at the same time

Method used

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  • Double-magnetic-response temperature-sensitive microcapsules and preparation method thereof
  • Double-magnetic-response temperature-sensitive microcapsules and preparation method thereof
  • Double-magnetic-response temperature-sensitive microcapsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of magnetic Fe by co-precipitation method under nitrogen protection 3 o 4Nanoparticles (the particle size of the nanoparticles is specifically 20nm), the surface of the magnetic nanoparticles is modified with oleic acid, and the amount of the oleic acid is 5 to 100% (weight) of the magnetic nanoparticles; under the protection of nitrogen, the surface undergoes Modified magnetic nanoparticles and N-isopropylacrylamide, N'N-methylenebispropylamide comonomers are grafted and polymerized in the presence of a free radical initiator, azobisisobutyronitrile, and the reaction temperature is 50 ~100°C, the weight of N-isopropylacrylamide and N'N-methylenebispropylamide comonomer is 50-1500% of the weight of magnetic nanoparticles, and N'N-methylenebispropylamide is specific In order to act as a crosslinking agent, the weight of azobisisobutyronitrile is 1.0 to 20.0% of the weight of N-isopropylacrylamide and N'N-methylenebispropylamide comonomer, thus forming a warm...

Embodiment 2

[0040] Preparation of magnetic Fe by co-precipitation method under nitrogen protection 3 o 4 Nanoparticles (the particle size of the nanoparticles is specifically 20nm), the surface of the magnetic nanoparticles is modified with oleic acid, and the amount of the oleic acid is 5 to 100% (weight) of the magnetic nanoparticles; under the protection of nitrogen, the surface undergoes Modified magnetic nanoparticles and N-isopropylacrylamide, N'N-methylenebispropylamide, methacrylic acid mixed monomers were encapsulated by graft polymerization in the presence of free radical initiator azobisisobutyronitrile , the reaction temperature is 50-100°C, the weight of the above-mentioned mixed monomers is 50-1500% of the weight of the magnetic nanoparticles, and the weight of the free radical initiator is 1.0-20.0% of the weight of the above-mentioned mixed monomers, thereby forming temperature-sensitive magnetic nano-microspheres Specifically, the results of the transmission electron mic...

Embodiment 3

[0042] Preparation of magnetic Fe by co-precipitation method under nitrogen protection 3 o 4 Nanoparticles (the particle size of the nanoparticles is specifically 20nm), the surface of the magnetic nanoparticles is modified with oleic acid, and the amount of the oleic acid is 5 to 100% (weight) of the magnetic nanoparticles; under the protection of nitrogen, the surface undergoes Modified magnetic nanoparticles and N-isopropylacrylamide, N'N-methylenebispropylamide, and acrylamide mixed monomers are grafted and polymerized in the presence of a free radical initiator, azobisisobutyronitrile. The reaction temperature is 50-100°C, the weight of the above-mentioned mixed monomer is 50-1500% of the weight of the magnetic nanoparticles, and the weight of the free radical initiator is 1.0-20.0% of the weight of the monomer, thereby forming temperature-sensitive magnetic nano-microspheres; specifically , The results of transmission electron microscopy show that in this example, the s...

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Abstract

The invention discloses double-magnetic-response temperature-sensitive microcapsules and a preparation method thereof. A temperature-sensitive polymer is coated on the surface of magnetic nanoparticles and filled into the wall material of the microcapsules; under the action of an alternating magnetic field, the magnetic particles generates heat due to a magnetic lag effect the temperature of the magnetic particles thus rises, and when the temperature T is higher than the lowest critical solution temperature (LCST), the wall material forms lots of pores due to the shrinkage of the temperature-sensitive nanoparticles, the diffusion resistance to the medicine molecules passing through the wall material of the microcapluses is small and the release speed is high; and when the temperature T reaches the LCST, the temperature-sensitive magnetic nanoparticles expand to fully fill the pores in the wall material of the microcapsules, the diffusion resistance to the medicine molecules passing through the wall material of the microcapsules is big, and the release speed is low. Therefore, by regulating the synergetic effect between the temperature-sensitive structure of the temperature-sensitive polymer on the surfaces of the magnetic nanoparticles and the magnetothermal effect of the alternating magnetic field, the controlled release of the embedded medicine is realized. The microcapsulesprepared by the invention have double magnetic response and a temperature-sensitive controlled-release property.

Description

technical field [0001] The invention relates to the field of intelligent microcapsules, in particular to a double magnetic response temperature-sensitive microcapsule and a preparation method thereof. Background technique [0002] Targeting drug delivery system (TDDS) can deliver drugs to lesion sites in humans or animals through carriers, which can not only improve the utilization rate of drugs and reduce the dosage of drugs, but also effectively reduce or even eliminate the effect of drugs on other normal diseases. Toxic side effects of the site. Therefore, the targeted drug delivery system is one of the research hotspots in the field of biomedicine. As an important part of the targeted drug delivery system, the selection and intelligent design of the targeted drug carrier, and its impact on drug targeted delivery and controlled release The impact has been widely concerned and valued by people. [0003] Microcapsules have broad application prospects in the field of targe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/38A61K47/04A61J3/07A61K9/50
Inventor 蔡力锋温裕乾王春丽
Owner PUTIAN UNIV
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