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Guava leaf extract with function of reducing blood sugar as well as preparation method and application thereof

A guava leaf and hypoglycemic technology is applied in the field of guava leaf extract and its preparation, and achieves the effects of clear ingredients, improving insulin sensitivity index and improving insulin level.

Active Publication Date: 2013-01-16
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent ZL 01806328.4 introduces "α-amylase activity inhibitor", but this patent only relates to an α-amylase activity inhibitor obtained from guava leaves containing polyphenols as active ingredients for Type II Prevention and treatment of diabetes
Chinese patent CN 200610041855.4 introduces "preparation method of flavonoids from guava leaves", but this patent only involves the preparation method of total flavonoids from guava leaves and its effect on treating type II diabetes and related complications
However, there is no report on the prevention and treatment of type II diabetes mellitus by the total triterpene acids in guava leaves.

Method used

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  • Guava leaf extract with function of reducing blood sugar as well as preparation method and application thereof
  • Guava leaf extract with function of reducing blood sugar as well as preparation method and application thereof
  • Guava leaf extract with function of reducing blood sugar as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, the preparation of guava leaf extract

[0026] Dried guava (Psidium guajava L.) (produced in Guangdong Conghua) leaves 2.0kg, crushed and passed through a 20m mesh sieve, extracted by diafiltration with 25L of 95% ethanol, filtered the extract, concentrated under reduced pressure to 2L, and then added 2L water, boiled for 15-20 minutes, cooled, centrifuged (rotating speed 4000 rpm, 10min), to obtain 103g of water-insoluble matter (i.e. precipitate), which is guava leaf extract. After determination, the mass content of total triterpene acids is 56%.

Embodiment 2

[0027] Embodiment 2, the preparation of guava leaf extract

[0028] Dried guava (Psidium guajava L.) leaves (produced in Conghua, Guangdong) 1.0kg, crushed and sieved through a 20-mesh sieve, heated and refluxed with 5L of methanol to extract 3 times, 3 hours each time. Filter the extract, concentrate under reduced pressure to dry weight 155g, then add about 4L of water, boil for 15-20 minutes, after cooling, centrifuge (speed 4500 rpm, 10min) to obtain water-insoluble matter (i.e. precipitate) 60g. The water-insoluble matter was washed 3 times with 200 mL of petroleum ether, and suction-filtered to obtain 39 g of petroleum ether-insoluble matter, which was guava leaf extract. After determination, the mass content of total triterpene acids is 73%.

Embodiment 3

[0029] Embodiment 3, the preparation of guava leaf extract

[0030] Dry guava (Psidium guajava L.) (produced in Conghua, Guangdong) leaves 2.0kg, after crushing, pass through a 20m mesh sieve, extract by percolation with 25L of 95% ethanol, filter the extract, concentrate under reduced pressure to dry weighing 356g, Then add about 8L of water, boil for 15-20 minutes, after cooling, centrifuge (4500 rpm, 10min) to obtain 129g of water-insoluble matter (ie, precipitate). The water-insoluble matter was washed 3 times with 300 mL of petroleum ether, and suction filtered to obtain 87 g of petroleum ether-insoluble matter. Add 170 ml of absolute ethanol and 1 g of activated carbon to the petroleum ether-insoluble matter, reflux for 30 minutes for decolorization, and filter under heat. The filtrate was evaporated to dryness to obtain 65 g of light yellow powder, which was guava leaf extract. After determination, the mass content of total triterpene acids is 87%.

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PUM

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Abstract

The invention discloses a guava leaf extract with a function of reducing blood sugar as well as a preparation method and application thereof. The guava leaf extract with the function of reducing blood sugar is characterized by comprising 20-99% of total triterpenoid acid. The preparation method of the guava leaf extract comprises the following steps of: heating and reflowing or percolating and extracting guava leaves with ethanol or methanol; decompressing and concentrating to obtain extractum; adding water to the extractum and stirring the extractum; centrifuging; taking out sediments to obtain the guava leaf extract with the function of reducing blood sugar. The guava leaf extract can be used for preparing a medicament and a health care product for preventing and treating diabetes type II and has the advantages of clear effective part components, less toxicity, strong pharmacological effects, favorable pharmaceutical prospect, simple preparation process and easiness for large scale production.

Description

technical field [0001] The invention belongs to the field of plant natural medicines, and in particular relates to a guava leaf extract with hypoglycemic effect, a preparation method and application thereof. Background technique [0002] Insulin resistance refers to a pathophysiological state in which body tissues or target cells lack normal response to insulin, and their sensitivity or responsiveness is reduced. A large number of studies have shown that insulin resistance is one of the most important pathogenesis of type II diabetes, and runs through the entire process of the occurrence and development of diabetes, and is also the basis of the "motive force" leading to various complications of diabetes. Insulin resistance and the resulting compensatory hyperinsulinemia are closely related to the high incidence of type II diabetes, hyperlipidemia, hypertension and coronary heart disease in the population. This metabolic cardiovascular disease syndrome is called "X Syndrome"...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/61A61P3/10A61K127/00
Inventor 张晓琦叶文才叶春玲赵晶晶范春林王英邵萌张建张冬梅
Owner JINAN UNIVERSITY
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