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Humic acid active component and preparation method, application and pharmaceutical composition thereof

An active ingredient, humic acid technology, applied in the direction of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., can solve problems such as long-term use, kidney side effects, etc., to reduce scars, stop bleeding, and improve blood circulation. better effect

Active Publication Date: 2011-11-16
黑龙江臻旸生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the side effects of oral corticosteroids or non-steroidal anti-inflammatory drugs such as ibuprofen and indomethacin on the gastrointestinal tract, liver and kidney, it cannot be used for a long time

Method used

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  • Humic acid active component and preparation method, application and pharmaceutical composition thereof
  • Humic acid active component and preparation method, application and pharmaceutical composition thereof
  • Humic acid active component and preparation method, application and pharmaceutical composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1. Preparation of humic acid active component and its effect experiment on hemostasis and blood circulation

[0039] Method 1: Take 100 parts of peat natural humic acid (number average molecular weight 2000), and use the total amount of lipase in Trichoderma reesei and Bacteroides succinicum (i.e. the total amount of natural humic acid + lipase + catalase ) 0.05% (mass percentage), catalase (lipase and catalase can follow the literature "Zhang Chenyun, Liu Jinfu, Wang Na, Wang Bu, research on the separation and screening of Dongzao fruit wine brewing yeast. China brewing, 2010 (8 ): 43-47 " from Trichoderma reesei, Bacteroides succinici by the method screening) accounts for 0.05% (mass percentage) of the total amount (referring to the total amount of natural humic acid+lipase+catalase), For biodegradation, the temperature is 35°C, the time is 65 hours, the mass concentration of lipase is 0.2%, the mass concentration of catalase is 0.3%, and the humic acid active...

Embodiment 2

[0047] Example 2 Preparation of active components of humic acid and its effects of astringent, blood circulation, and treatment of rheumatoid arthritis

[0048] Method 1: Take 200 parts of peat natural humic acid (number average molecular weight 3000), respectively take lipase and catalase from 0.35 part of yeast and 0.3 part of Alcaligenes (refer to "Pulphus euphratica et al. Catalase and Co-immobilization of yeast cells. Journal of Hunan Agricultural University, 2001, 21(2): 164-166" was carried out in 0.06 parts each, and the humic acid active group was obtained by degradation (degradation temperature 25-65°C, time 48-102hr). points. The active component is analyzed (infrared spectrum see figure 2 ), figure 2 Among them, the characteristic of the first line was not detected; the characteristic of the second line was C-27 cholestane with steroids; the characteristic of the third line was the analogue of sodium lignosulfonate (with Humic acid degradation products of terpe...

Embodiment 3

[0053] Example 3 Preparation of active components of humic acid and its effects on anti-inflammation, promoting blood circulation and removing blood stasis, and treating systemic erythema

[0054] Method 3: Get 300 parts of peat natural humic acid (number-average molecular weight 1500), and simultaneously take cellulase in actinomycetes and yeasts with a weight ratio of 0.5:0.2 (Shao Jihai; Hu Junlin; Sun Yulin; He Shaojiang; Feng Xinmei. A strain producing Research on solid fermentation of thermotolerant cellulase actinomycetes. Solid fermentation, 2006(24): 37-39), biochemical humic acid enrichment at a temperature of 55°C and a time of 65hr, culture medium—potassium carbonate, urea and The content of superphosphate in the aqueous solution is 10g / L, 10g / L, and 15g / L respectively, and it is detected by LC-MS and NMR, and the fat-soluble / hydrophilic group ratio is calculated to be 5 / 2. Mix 28 parts by mass of humic acid active components, 5+2 parts of licorice-anthocyanidin, 4...

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Abstract

The invention discloses a humic acid active component and a preparation method, application and pharmaceutical composition thereof. The humic acid active component is obtained by biodegradation of natural humic acid, or by selection of plant materials and enrichment through a biochemical humic acid technology. The humic acid active component disclosed by the invention has the efficacies of arresting bleeding, promoting blood circulation, resisting inflammation, resisting rheumatism and removing blood stasis, can be used for preventing or treating lupus erythematosus, and has better effects on arresting bleeding and promoting blood circulation compared with that of Yunnan Baiyao and common humic acid.

Description

technical field [0001] The invention specifically relates to a humic acid active component, its preparation method, application and pharmaceutical composition containing it. Background technique [0002] According to investigations, the existing traditional Chinese medicines that can stop bleeding and activate blood mainly contain "Sanqi" medicinal material. "Notoginseng" contains not only the "Notoginseng" component that stops bleeding, but also the "Notoginseng saponins" component that promotes blood circulation. However, there is a certain dose-effect relationship with the amount of the drug when it is used to stop bleeding or activate blood circulation to treat blood stasis. Otherwise, it will backfire. [0003] There are many types of anti-inflammatory and anti-rheumatic drugs, such as glucocorticoids and non-steroidal anti-inflammatory drugs. Because oral corticosteroids or non-steroidal anti-inflammatory drugs such as ibuprofen and indomethacin have side effects on...

Claims

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Application Information

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IPC IPC(8): C12P1/00A61K35/02A61K35/10A61K36/16A61K36/534A61K36/81A61K36/8962A61K36/896A61K9/70A61P7/04A61P17/02A61P19/02A61P29/00A61P37/02
Inventor 曾宪成周霞萍韩立新谢兆佳史萍刘建文
Owner 黑龙江臻旸生物科技有限公司
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