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Preparation method for coptis chinensis total alkaloid effervescent tablets, and use of coptis chinensis total alkaloid effervescent tablets in treating female reproductive system diseases

A technology of total alkaloids and effervescent tablets, applied in sexual diseases, drug delivery, drug combination and other directions, can solve the problems of inconvenience of carrying, slow release of suppositories, easy deterioration, etc., and achieve convenient administration, rapid disintegration, and storage period long effect

Inactive Publication Date: 2012-01-04
CHANGCHUN UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, after women use ordinary tablets for external use, the active ingredients often need to be decomposed for a long time before they can be released; while the liquid medicine releases the active ingredients quickly, but it is inconvenient to carry and easily deteriorates, and the release speed of suppositories is slow.

Method used

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  • Preparation method for coptis chinensis total alkaloid effervescent tablets, and use of coptis chinensis total alkaloid effervescent tablets in treating female reproductive system diseases
  • Preparation method for coptis chinensis total alkaloid effervescent tablets, and use of coptis chinensis total alkaloid effervescent tablets in treating female reproductive system diseases
  • Preparation method for coptis chinensis total alkaloid effervescent tablets, and use of coptis chinensis total alkaloid effervescent tablets in treating female reproductive system diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] (1) Take an appropriate amount of the whole plant of the yellow lotus plant, crush it to coarse powder, add 4 times the volume of sulfuric acid aqueous solution (0.1%), soak and extract at room temperature for 24 hours, and filter twice; (2) Take the extract and add milk of lime to adjust the pH to 7, and place it 8 hours, filter, (3) take the extract and add concentrated hydrochloric acid to adjust the pH to 2-3, let it stand for 8 hours, and filter; (4) take the precipitate and add 50 times the volume of water to boil and dissolve, adjust the pH to 8-9 with milk of lime, and filter while it is hot; (5) Take the filtrate and wash it with water, drain it, and dry it to obtain the total alkaloids of Coptidis Rhizoma; Glycol and ethanol mixture is b; (7) adopt the spray starch absorption drying method of the microcapsule preparation method, spray b through the sprayer in the rotary coating pan containing a, and finally pass through the No. 2 sieve to form c; ( 8) Pass the...

Embodiment 2

[0137] (1) Take an appropriate amount of the whole plant of Coptis chinensis, crush it to coarse powder, add 4 times the volume of sulfuric acid aqueous solution (0.5%), soak and extract at room temperature for 24 hours, and filter for 3 times; (2) Take the extract and add milk of lime to adjust the pH to 7, place it After 10 hours, filter, (3) take the extract and add concentrated hydrochloric acid to adjust the pH to 2-3, let it stand for 10 hours, and filter; (4) take the precipitate and add 50 times the volume of water to boil to dissolve, adjust the pH to 8-9 with milk of lime, and filter while it is hot; (5) Take the filtrate and wash it with water, drain it, and dry it to obtain the total alkaloids of Coptidis Rhizome; Glycol and ethanol mixture is b; (7) adopt the spray starch absorption drying method of the microcapsule preparation method, spray b through the sprayer in the rotary coating pan containing a, and finally pass through the No. 2 sieve to form c; ( 8) Pass ...

Embodiment 3

[0139] (1) Take an appropriate amount of the whole plant of Coptis chinensis, crush it into a coarse powder, add 15 times the volume of sulfuric acid aqueous solution (1%), soak and extract at room temperature for 24 hours, and filter 5 times; (2) Take the extract and add milk of lime to adjust the pH to 7, place it After 12 hours, filter; (3) take the extract and add concentrated hydrochloric acid to adjust the pH to 2-3, let it stand for 12 hours, and filter; (4) take the precipitate and add 50 times the volume of water to boil to dissolve, adjust the pH to 8-9 with milk of lime, and filter while it is hot; (5) Take the filtrate and wash it with water, drain it, and dry it to obtain the total alkaloids of Coptidis Rhizoma; (6) dissolve 5 parts of polyethylene glycol 6000 in 15 parts of ethanol, add 30 parts of sodium bicarbonate to obtain sodium bicarbonate, polyethylene glycol Glycol and ethanol mixture is b; (7) adopt the spray starch absorption drying method of the microca...

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Abstract

The invention relates to a preparation method for coptis chinensis total alkaloid effervescent tablets. The method comprises the following steps: crushing a proper amount of the entire plant of the coptis chinensis into thick powder; adding an aqueous solution of sulphuric acid to the thick powder, wherein the volume of the aqueous solution of the sulphuric acid is 4-15 times the volume of the thick powder, the concentration of the the aqueous solution of the sulphuric acid is 0.1-1%; carrying out soak extraction at a room temperature for 24 hours, and carrying out filtering for 2-5 times; adding lime cream to the resulting extracting solution to adjust a pH value to 7, standing for 8-12 hours, then carrying out filtering; adding concentrated hydrochloric acid to the resulting extracted solution to adjust the pH value to 2-3, standing for 8-12 hours, then carrying out filtering; adding water to the precipitation to boil and dissolve the precipitation, wherein the volume of the water is 50 times the volume of the precipitation; adding the lime cream to the precipitation to adjust the pH value to 8-9, then carrying out filtering while hot; carrying out steps of washing through the water, water pumping out and drying for the resulting filtrate to obtain the coptis chinensis total alkaloid a; ; dissolving 2-5 parts of polyethylene glycol 6000 in 5-15 parts of ethanol, then adding 15-30 parts of sodium bicarbonate to obtain a mixed solution b comprising the sodium bicarbonate, the polyethylene glycol and the ethanol; adopting a spraying starch adsorption drying method in the preparation method for the micro encapsulate to spry the b through a nebulizer in a rotation coating pan filled with the a; adopting a II sieve for the treated b to pelletize into the C; adopting the II sieve for citric acid to pelletize into citric acid particles; adopting a VII sieve for the citric acid particles and the C, then uniformly mixing the screened citric acid particles and the C, carrying out tabletting, wherein the weight of each tablet is 1 g, and the infrared ray is adopted for irradiating the position of the filler inlet during the tabletting process. The effervescent tablets provided by the present invention is easy to be carried, has rapid onset, and provides high and exact therapeutic effects for treatment of the female reproductive system diseases.

Description

technical field [0001] The invention relates to a preparation method of Coptis chinensis total alkaloid effervescent tablet and its application in treating female reproductive system diseases, belonging to the technical field of traditional Chinese medicine. Background technique [0002] At present, the active component of Coptis chinensis - the total alkaloids of Coptis chinensis has special curative effect for treating intestinal diseases, but it has not been found to be used for treating female reproductive system diseases. At present, after women use ordinary tablets for external use, the active ingredients often need to be decomposed for a long time before they can be released; while the liquid medicine releases the active ingredients quickly, but it is inconvenient to carry and easily deteriorates, and the release speed of suppositories is slow. Contents of the invention [0003] The object of the present invention is to provide a preparation method of Coptis chinens...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/46A61P15/00
Inventor 张辉张红林喆
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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