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Nanometer composite gel dressing containing baicalin and soapstone and preparation method for nanometer composite gel dressing

A nano-composite, baicalin technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of easy rupture and exudation, and achieve the effects of good biocompatibility and antibacterial performance, mild conditions, and convenient operation

Active Publication Date: 2012-02-01
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the reported baicalin thermosensitive gel is liquid at normal temperature, if it is touched by a sharp object, it is easy to break and ooze out.

Method used

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  • Nanometer composite gel dressing containing baicalin and soapstone and preparation method for nanometer composite gel dressing
  • Nanometer composite gel dressing containing baicalin and soapstone and preparation method for nanometer composite gel dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0045] 1) Dispersion of inorganic nano-saponite particles: at 22°C, add 0.2 g of hectorite to 10 mL of deionized water, and stir for 20 min until completely dispersed to form a transparent solution;

[0046] 2) Preparation of gel dressing: under nitrogen protection and magnetic stirring, first add 1.0 g of isopropylacrylamide to the above transparent solution, then cool down to 3°C with ice cubes, add 0.01 g of ammonium persulfate, and stir for 20 minutes. Inject 80 μL of tetramethylethylenediamine aqueous solution with a mass percentage concentration of 2%, and slowly pour the solution into a glass vessel with a thickness of 2 mm after 15 minutes, seal it and carry out in-situ free radical polymerization reaction, control the reaction temperature at 22°C for 36 hours Stop reaction after;

[0047] 3) Purification of the gel dressing: Cut the reacted product into thin slices with a diameter of about 10mm, soak them in deionized water and absolute ethanol for 1 week respectively...

Embodiment 2

[0051] 1) Dispersion of inorganic nano-saponite particles: at 20°C, add 0.1 g of hectorite to 10 mL of deionized water, and stir for 15 min until completely dispersed to form a transparent solution;

[0052] 2) Preparation of gel dressing: under nitrogen protection and magnetic stirring, first add 1.1g of isopropylmethacrylamide to the above transparent solution, then cool down to 2°C with ice cubes, add 0.01g of potassium persulfate, and stir for 15 minutes Finally, inject 100 μL of sodium sulfite aqueous solution with a mass percentage concentration of 1%, and slowly pour the solution into a glass vessel with a thickness of 2 mm after 20 minutes. After sealing, carry out in-situ free radical polymerization reaction, control the reaction temperature at 23 ° C, and stop the reaction after 40 hours ;

[0053] 3) Purification of the gel dressing: Cut the reacted product into thin slices with a diameter of about 10mm, soak them in deionized water and absolute ethanol for 1 week r...

Embodiment 3

[0057] 1) Dispersion of inorganic nano-saponite particles: at 25°C, add 0.3 g of stesterite to 15 mL of deionized water, and stir for 25 min until completely dispersed to form a transparent solution;

[0058] 2) Preparation of gel dressing: under nitrogen protection and magnetic stirring, first add 1.5g of isopropylacrylamide to the above transparent solution, then cool down to 1°C with ice cubes, add 0.015g of ammonium persulfate, and stir for 20 minutes. Inject 120 μL of an aqueous solution of tetramethylpropylenediamine with a concentration of 0.5% by mass, and pour the solution slowly into a glass vessel with a thickness of 2 mm after 15 minutes. After sealing, carry out in-situ free radical polymerization reaction, and control the reaction temperature at 24°C for 48 hours Stop reaction after;

[0059] 3) Purification of the gel dressing: Cut the reacted product into thin slices with a diameter of about 10mm, soak them in deionized water and absolute ethanol for 1 week res...

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Abstract

The invention relates to a nanometer composite gel dressing containing baicalin and soapstone and a preparation method for the nanometer composite gel dressing. The nanometer composite gel dressing containing the baicalin and the soapstone comprises the following ingredients of: alkyl acrylamide monomers, inorganic nanometer soapstone grains, an initiator, a catalyst, the baicalin, deionized water and absolute ethanol. The preparation method comprises the following steps of: (1) dispersing the inorganic nanometer soapstone grains; (2) preparing a gel dressing; (3) purifying the gel dressing; and (4) adsorbing the baicalin by the gel dressing. The preparation method has the core that the nanometer composite gel dressing crosslinkd with the soapstone is soaked in absolute ethanol solution of the baicalin. The nanometer composite gel dressing is high in biocompatibility and antibacterial performance, and can be used for skin trauma, ulcers, burn, scald and other skin diseases. The nanometer composite gel dressing and the preparation method have the advantages that a preparation process is simple, the condition is mild, the transparency and toughness of the dressing are high, and the absorption and release of the baicalin are controllable.

Description

technical field [0001] The invention relates to the fields of pharmaceutical preparations, inorganic nanometer materials, biological materials and intelligent polymer materials, in particular to a nanocomposite gel dressing containing baicalin and saponite and a preparation method thereof. Background technique [0002] Hydrogels are a kind of hydrophilic but water-insoluble polymers, which can quickly swell to an equilibrium volume in water and still maintain their shape and three-dimensional space network structure, and dehydrate under certain conditions. Deswelling is a kind of functional polymer material that integrates water absorption, water retention and slow release and is developing rapidly. Intelligent or smart hydrogels are a class of hydrogels that can respond sensitively to external stimuli such as physical stimuli such as heat, gas, electricity, magnetism, and mechanical energy, as well as pH values, salt concentrations, and chemical substances. Nanocomposite g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/42A61L15/44
Inventor 张青松郭文娟李捷陈莉赵义平苑红蕊
Owner TIANJIN POLYTECHNIC UNIV
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