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Formula of functional dressing and preparation method thereof

A functional chitosan technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of unfavorable human health, poor biodegradability of film-forming agents, limited bactericidal function, etc., and achieve the effect of promoting wound healing and good effect Effect

Inactive Publication Date: 2012-02-01
边俊杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 2. Most of the existing functional dressings are only limited to the bactericidal function, that is, there are only bactericides and auxiliary materials in the formula, but no other functions, such as general disinfectant
[0005] 3. The film-forming agent used in some liquid functional dressings that can form a film after spraying has poor biodegradability and is only suitable for the application of superficial skin wounds, such as liquid excipients made of polyvinyl alcohol and acrylate emulsion PSA (Chinese invention patent application with application number 200610012150)
[0006] 4. Most of the liquid dressings that use organic solvents as solvents are irritating and will make patients feel painful and unbearable. Anesthetics are needed to relieve pain
[0007] 5. Certain functional dressings that use nano-silver or other heavy metals as fungicides will cause heavy metal residues, which is harmful to human health (Chinese invention patent application with application number 200610083191.8)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The 200mg / L sodium chloride solution was electrolyzed until the hypochlorite ion content was 40mg / L, as solution A. Take 1.5g of dialkyl quaternary ammonium salt, 0.8g of chlorhexidine acetate, and 0.8g of collagen, dissolve them in 100mL of solution A, and configure them as solutions B, C, and D. Take another chitosan 0.8g to 1L beaker, swell with 300mL of solution A, let it stand still, if it does not dissolve, add dilute acetic acid dropwise, stir until dissolved while adding, let stand for 1h. Pour the above solutions B, C and D into a beaker and mix them with the chitosan solution, add solution A to make up the volume, stir evenly, fill and sterilize by radiation.

Embodiment 2

[0027] 150 mg / L sodium chloride solution was electrolyzed to a hypochlorite ion content of 30 mg / L, as solution A. Take 1.5g of dialkyl quaternary ammonium salt, 0.5g of chlorhexidine acetate, and 0.6g of collagen, respectively, dissolve them in 100mL of solution A, and configure them as solutions B, C, and D. Take another 0.5g to 1L chitosan, swell it with 300mL of solution A, and let it stand still. If it does not dissolve, add dilute acetic acid dropwise, stir until it dissolves, and let stand for 1h. Pour the above solutions B, C and D into a beaker and mix them with the chitosan solution, add solution A to make up the volume, stir evenly, fill and sterilize by radiation.

Embodiment 3

[0029] The 100 mg / L sodium chloride solution was electrolyzed to a hypochlorite ion content of 20 mg / L, as solution A. Take 1.5g of dialkyl quaternary ammonium salt, 1.0g of chlorhexidine acetate, and 1.0g of collagen, respectively, dissolve them in 100mL of solution A, and configure them as solutions B, C, and D. Take another 1.0-1L chitosan beaker, swell it with 300mL of solution A, and let it stand still. If it does not dissolve, add dilute acetic acid dropwise, stir until dissolved, and let stand for 1h. Pour the above solutions B, C and D into a beaker and mix them with the chitosan solution, add solution A to make up the volume, stir evenly, fill and sterilize by radiation.

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PUM

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Abstract

The invention discloses functional dressing having three functions of antibiosis, hemostasis and wound healing promoting and a preparing method thereof. The functional dressing is a novel compound preparation which makes use of a sodium chloride solution subjected to electrochemical treatment as a solvent and contains dialkyl quaternary ammonium salt, chlorhexidine acetate, chitosan, collagen and the like as main active ingredients. The functional dressing has obvious inhibitory activity for the growth of a variety of pathogenic bacteria, and has no irritation to skin and mucosa, and is suitable for the treatments of skin, mucosa and wound infection and has the function of sterilization treatment of sites subjected to surgery and injection, wound surfaces (all types of surgical incisions, I-II burn, scald, open trauma surgery) and suppurative wound infection, mucosal sterilization, itching relieving and wound healing promoting.

Description

technical field [0001] The invention relates to a medical material and a preparation method thereof, in particular to a formula and a preparation method of a functional dressing with antibacterial, hemostasis and wound healing promotion. technical background [0002] The traditional method of treating skin or mucous membranes and wound damage is to cover with powdered medicine or make it into a patch form, such as using plant fiber gauze as a drug delivery carrier, carrying the medicine and covering the wound surface, which is not convenient to use and also Not suitable for mucosal administration. With the continuous improvement of demand, new types of medical functional dressings gradually appear, such as various disinfectants. The existing functional dressings have the following problems: [0003] 1. Most of the existing liquid dressings are still liquid after spraying, which is easy to stick to dust and clothes. Therefore, when using this kind of liquid dressing, try to...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/44
Inventor 边俊杰
Owner 边俊杰
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