Preparation methods of poppy shell extract and cough tablet

Abstract

The invention discloses a preparation method of poppy shell extract. The method comprises the following steps: (1) crushing poppy shells to obtain coarse powder of poppy shell; (2) extracting and refluxing for 2.5 to 3.5 hours by adding 4 to 10 times of 50-100 percent ethanol to obtain an extracting solution; (3) decocting and extracting residues with 4 to 10 times of basic aqueous solution for 1.5 to 2.5 hours to obtain an extracting solution; (4) decocting and extracting the residues with 4 to 10 times of water for 1.5 to 2.5 hours to obtain an extracting solution; and (5) concentrating the extracting solutions respectively and combining the concentrated extracting solutions, or combining and concentrating the extracting solutions to obtain thick paste, and drying to obtain the poppy shell dry extract powder. The invention also discloses a preparation method of a cough tablet, which is prepared from aster, platycodon root, stemona root, dried tangerine peel, fineleaf schizonepeta herb, whiteflower hogfennel root, tangerine, bitter orange, Chinese magnoliavine fruit, dry ginger, liquorice, the poppy shell extract, ammonium chloride, dementholized peppermint oil and pharmaceutical conventional auxiliary materials.

Description

technical field [0001] The invention relates to a preparation method of poppy shell extract, a cough suppressant tablet prepared from the poppy shell extract and a preparation method of the cough suppressant tablet. Background technique [0002] Zhikebao Tablets is a Chinese patent medicine created by Cheng Zhongling, a famous doctor in the Qing Dynasty, on the basis of the famous prescription "Zhikesan" included in "Medical Mind Awareness". A compound preparation prepared by extracting medicinal materials such as aster, platycodon, peucedanum, tangerine peel, nepeta, peucedanum, orange red, poppy shell extract, citrus aurantium, schisandra, dried ginger, licorice, ammonium chloride, and mint oil. It has the effects of clearing the lung and eliminating phlegm, relieving cough and relieving asthma. It is used for cough, excessive phlegm, clear and thin, cough and even wheezing caused by exogenous wind and cold; chronic bronchitis and upper respiratory tract infection see the ...

AI Technical Summary

Problems solved by technology

[0003] But this variety has the following disadvantages: the preparation process is simple, especially the preparation process of poppy shell extract is unreasonable, and the content of active ingredients is not high; the detection method adopts a simple ultraviolet absorption method, the detection accuracy and precision are not high, and the product cannot be accurately controlled. quality, etc.

The content of morphine was measured by spectrophotometry. During the production inspection, it was found that the content of morphine fluctuated greatly, which caused difficulties in the quality control of production. After analysis, the preparation process of the test solution was complicated, resulting in the easy loss of morphine in the sample, and the operation time was long and the operation intensity was high. At the same time, during several years of production testing, it was found that the dry paste powder extracted from other ingredients of Zhikebao tablets interfered to varying degrees in the determination of morphine by UV spectrophotometry, resulting in falsely high morphine content

On the other hand, a large amount of organic solvents such as benzene and chloroform are used in the preparation of the test solution, which is highly toxic and has a great impact on the health of operators;

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