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Pholcodine-containing compound pharmaceutical preparation for treating cold

A technology for pharmaceutical preparations and phorcodine, which is applied in the field of pharmaceutical preparations and can solve problems such as strong side effects and inability to effectively alleviate them

Active Publication Date: 2014-03-05
YICHANG HUMANWELL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent can only be used for relieving cough and asthma, but it cannot effectively relieve fever, headache, sore limbs, sneezing, runny nose and nasal congestion caused by colds
At the same time, because it contains chlorpheniramine maleate, it produces strong side effects when used daily

Method used

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  • Pholcodine-containing compound pharmaceutical preparation for treating cold
  • Pholcodine-containing compound pharmaceutical preparation for treating cold
  • Pholcodine-containing compound pharmaceutical preparation for treating cold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1 utilizes the compound tablet that spray granulation method makes to contain different amounts

[0080] Table 1, compound tablet of the present invention form

[0081]

[0082] Preparation

[0083] In a 100,000-class clean area

[0084] A crosses 100 mesh sieves with pholcodine, paracetamol, pseudoephedrine hydrochloride, diphenhydramine hydrochloride (night use);

[0085] B receives a small amount of starch for mixing, adds half of the prescription amount of Tween 80 and stirs to make an adhesive;

[0086] C takes the prescribed amount of povidone, adds purified water and Tween 80 and stirs to make an adhesive;

[0087] D paracetamol, pseudoephedrine hydrochloride, diphenhydramine hydrochloride (night use) and starch, sodium carboxymethyl starch are put into premixed boiling granulator;

[0088] E successively spray the adhesive and the adhesive into the boiling granulator with a peristaltic pump, and turn off the peristaltic pump after spraying. Dr...

Embodiment 2

[0090] Embodiment 2 utilizes the compound tablet that extrusion granulation method makes

[0091] Table 2, compound tablet of the present invention.

[0092]

[0093] Preparation

[0094] In a 100,000-class clean area

[0095] A crosses 100 mesh sieves with pholcodine, paracetamol, pseudoephedrine hydrochloride, diphenhydramine hydrochloride (night use);

[0096] B takes the main ingredient and microcrystalline cellulose of prescription dosage, precrossed starch, PVPP, and mixes evenly;

[0097] C3% PVP solution for softening, 18# granulation, drying, moisture control 3%;

[0098] D18 mesh granules, mixed with magnesium stearate, compressed into tablets.

Embodiment 3

[0099] The compound syrup that embodiment 3 makes

[0100] Table 3, compound syrup of the present invention.

[0101] components

daily preparations

night preparation

Acetaminophen

325g

325g

Pholcodine

5

5g

Pseudoephedrine hydrochloride

30g

30g

Diphenhydramine hydrochloride

-

12.5g

citric acid

0.8g

0.8g

[0102] sucrose

some

some

Potassium sorbate

1.5g

1.5g

ethanol

Appropriate amount

Appropriate amount

artificial flavor

200μL

200μL

Co-made

1000Ml

1000mL

[0103] Preparation:

[0104] In a 100,000-class clean area

[0105] A540g sucrose is dissolved in 200mL boiled water to make syrup, filter;

[0106] B takes by weighing the prescribed amount of pholcodine, and dissolves it in an appropriate amount of ethanol;

[0107] C takes prescription quantity paracetamol, pseudoephedrine hydrochloride, d...

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PUM

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Abstract

The invention relates to the field of medicines, particularly a pharmaceutical preparation for treating cold and influenza. The pharmaceutical preparation comprises pholcodine, antipyretic analgesic and decongestant.

Description

[0001] This application is a divisional application of the application number 200910222919.4 and the title of the invention "a compound pharmaceutical preparation containing pholcodine for treating colds" submitted on November 13, 2009. technical field [0002] The invention relates to the field of pharmaceutical preparations, in particular to a compound pharmaceutical preparation containing pholcodine for treating colds. Background technique [0003] Influenza is a common respiratory disease caused by a variety of viruses, and has a high incidence rate. At present, the more practical treatment method is to relieve cold symptoms through the combination of antipyretic and analgesics, nasal decongestants, antihistamines and central cough suppressants--fever caused by colds, headache, sore limbs, sneezing , runny nose, stuffy nose, cough, etc. [0004] Central antitussives have strong antitussive effect and have mild sedative and analgesic effects; antipyretic and analgesic dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/5377A61P31/16A61P29/00A61P11/02A61P37/08A61P11/14A61P25/20A61K31/167A61K31/137A61K31/135
Inventor 符义刚杨玉萍朱卫国
Owner YICHANG HUMANWELL PHARMA