Preparation method of uniform-dimension polymer nano microspheres

A technology of nano-microspheres and polymers is applied in the field of preparation of polymer nano-microspheres of uniform size, and achieves the effects of low cost, high yield and highly controllable preparation process.

Active Publication Date: 2012-10-17
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, a variety of organic reagents such as monomers, cross-linking agents, initiators, and detergents need to be used, involving multiple steps such as reagent purification, heating and stirring, solvent evaporation, vacuum filtration, and washing. The ball size is above 1 micron, not suitable for applications with smaller size requirements

Method used

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  • Preparation method of uniform-dimension polymer nano microspheres
  • Preparation method of uniform-dimension polymer nano microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Place 1 gram of polystyrene and polymethyl methacrylate copolymer (molecular weight is 70,000) with a weight ratio of 1:0.3 in a 50 ml glass flask equipped with a reflux device, and then add 30 g propionic acid;

[0018] 2) Heat the liquid in the flask to 110°C with an oil bath and keep it for 10 hours;

[0019] 3) Stop heating and cool to room temperature to obtain polymer microspheres dispersed in propionic acid.

[0020] The scanning electron microscope (SEM) image of the obtained polymer microspheres is shown in figure 1 Shown; The diameter of the microspheres measured from the SEM image is 55 nanometers; and the size is uniform.

Embodiment 2

[0022] In Example 2, compared to Example 1 step 1), the amount of polymer used was increased to increase the yield, and the dissolution temperature was increased to reduce the time required for dissolution.

[0023] 1) 5 grams of polystyrene and polymethyl methacrylate with a weight ratio of 1: 0.3 (molecular weight of a copolymer of 70,000 Daltons) are placed in a 50-ml glass flask equipped with a reflux device, and then poured into the flask Add 30 grams of propionic acid;

[0024] 2) Heat the liquid in the flask to 150°C with an oil bath and keep it for 2 hours;

[0025] 3) Stop heating and cool to room temperature to obtain polymer microspheres dispersed in propionic acid.

[0026] Observing the obtained polymer microspheres with a scanning electron microscope, the diameter of the microspheres measured from the SEM image is also 55 nanometers, and the size is uniform.

Embodiment 3

[0028] Compared with Example 1, Example 2 changed the type, molecular weight, weight ratio of chain segments, and the weight ratio of copolymer to solvent to obtain polymer microspheres with different chemical compositions and particle sizes.

[0029] 1) 2 grams of polystyrene and poly(4-vinylpyridine) (molecular weight 20,000 Daltons) in a weight ratio of 1:0.2 are placed in a 25 ml glass flask equipped with a reflux device, and then Add 10 grams of propionic acid in the flask;

[0030] 2) Stir and heat the liquid in the flask to 30°C with an oil bath, and keep it for 10 minutes;

[0031] 3) Stop heating and cool to room temperature to obtain polymer microspheres dispersed in propionic acid.

[0032] Scanning electron microscope images of the resulting polymer microspheres are shown in figure 2 Shown; The diameter of the microspheres measured from the SEM image is 30 nanometers; and the size is uniform.

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Abstract

The invention relates to a preparation method of uniform-dimension polymer nano microspheres, which comprises the following steps: mixing copolymer and solvent in a certain proportion, and putting the mixture in a container; and heating the container containing the polymer and solvent to a certain temperature, and keeping for some time, thereby obtaining the polymer microspheres dispersed in solvent, wherein the copolymer is composed of a chain segment A and a chain segment B; the chain segment A is polystyrene, polymethylstyrene or polyacrylonitrile; and the chain segment B is polymethyl methacrylate, poly(N,N-dimethylaminoethyl methacrylate), dimethylamino methyl polymethacrylate, poly(2-vinyl pyridine), poly(4-vinyl pyridine) or polyoxyethylene. The polymer microspheres obtained by themethod provided by the invention have highly uniform dimension, and the particle size can be regulated within the range of 20-200nm. The method provided by the invention is simple, is not related to chemical reaction, has the advantages of short technical process, low cost and high yield, and is especially applicable to large-scale production.

Description

technical field [0001] The invention relates to a method for preparing polymer nanospheres with uniform size. The prepared polymer nanospheres can be used as standard metering substances, drug carriers, catalyst carriers, fillers, coatings, pigments, adsorbents, etc., and are widely used In precision instruments, precision machining, clinical testing, chemical separation, inspection and quarantine, environmental testing, material synthesis and other fields. Background technique [0002] Polymer microspheres are widely used in chemical, chemical, materials, biomedical engineering and other fields such as size standard substances, drug carriers, catalyst carriers, fillers, coatings, pigments, and adsorbents. The particle size, distribution and surface properties of polymer microspheres directly determine the performance and use effect in the application process. Especially in high-precision, high-value-added applications such as optoelectronic materials and reference material...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12
Inventor 汪勇邢卫红范益群
Owner NANJING UNIV OF TECH
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