Culture medium for producing kojic acid by fermenting aspergillus oryzae, and fermentation method thereof

Abstract

The invention provides a culture medium for producing kojic acid by standing fermentation of aspergillus oryzae. Every 1.5 liters of culture medium comprises the following components in weight: 10-30g of mannitol, 1-5g of yeast extract, 10-30g of maltose, 1-5g of monosodium glutamate, 3-15g of glucose, 1-10g of peptone, 50-200g of mashed potato and the balance of distilled water. The invention also provides a new standing fermentation method. The invention has the advantages of easy availability of raw materials, low energy consumption and high yield, and provides a new clue and a new method for research on fermentation of aspergillus oryzae and medical research on kojic acid.

Description

technical field [0001] The invention relates to the technical field of microorganism culture, and more specifically relates to a culture medium and a fermentation method for producing kojic acid by fermentation of Aspergillus oryzae. Background technique [0002] Kojic acid (5-hydroxy-2-hydroxymethyl-1,4-pyrone, English name Kojic acid), is a melanin-specific inhibitor, which can complex with copper ions in cells after entering skin cells , change the three-dimensional structure of tyrosinase, prevent the activation of tyrosinase, thereby inhibiting the formation of melanin. Kojic acid whitening active agents have better tyrosinase inhibitory effect than other whitening active agents. It does not act on other biological enzymes in the cells, and has no toxic effect on the cells. At the same time, it can also enter the intercellular matrix to form intercellular glial, which can retain water and increase skin elasticity. At present, it has been formulated into various cosmet...

AI Technical Summary

Problems solved by technology

At present, my country's kojic acid production technology is still relatively backward, with many production equipment, complicated operation, high energy consumption, and the production process needs to be improved