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Diacetone-D-galactose modified heteropoly acid hybrid and preparation method thereof

A technology of galactose and heteropolyacid, which is applied in the field of diacetone-D-galactose modified heteropolyacid hybrid and its preparation, can solve the problems of destruction, toxicity, harmfulness, etc., and achieve easy purification and less harsh conditions , The effect of facilitating the promotion and application

Inactive Publication Date: 2012-05-02
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This therapy is sometimes called "cytotoxic therapy" because the drugs used are harmful, even toxic, and the cells in the body, whether malignant or not, are destroyed, and even some anticancer drugs are not easily absorbed by specific cells

Method used

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  • Diacetone-D-galactose modified heteropoly acid hybrid and preparation method thereof
  • Diacetone-D-galactose modified heteropoly acid hybrid and preparation method thereof
  • Diacetone-D-galactose modified heteropoly acid hybrid and preparation method thereof

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Embodiment

[0026] Embodiment: Preparation of diacetone-D-galactose modified heteropolyacid hybrid, the steps are as follows:

[0027] 1) 2g of diacetone-D-galactose, 94mg of 4-dimethylaminopyridine, 922mg of succinic anhydride and 933mg of triethylamine are added to the container, dissolved in 100mL of toluene solvent, stirred and refluxed for 3 hours, and the reaction solution drops to Room temperature, spin-dried, the solid was dissolved in chloroform, extracted three times with deionized water, the separated organic phase was dried with anhydrous magnesium sulfate, spin-dried, the crude product was dissolved in 10 mL ethyl acetate, precipitated in 300 mL n-hexane, The product was filtered out, dissolved in 7 mL of ethyl acetate, precipitated twice in 350 mL of ethanol, and dried under vacuum to obtain a white powder which was 6-O-(3-carboxypropionyl)-1,2:3,4-di-O - isopropylidene-D-galactopyranose;

[0028]2) Add 258 mg of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline and 130 mL of ...

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Abstract

The invention provides a diacetone-D-galactose modified heteropoly acid hybrid which has a chemical formula of [(n-Bu)4N]3{MnMo6O18[(OCH2)3CNHCOC15H23O7]2}. A preparation method for the hybrid is as follows: diacetone-D-galactose is used as a starting material to react with succinic anhydride so as to prepare an intermediate product; the intermediate product reacts with molybdenum-containing polyoxometallate having an Anderson structure so as to obtain a hybrid compound connected through covalent bonds. The invention has the following advantages: an organic-inorganic hybridization method is employed for chemical modification of molybdenum-containing polyoxometallate, so connection of molybdenum-containing polyoxometallate with diacetone-D-galactose through covalent bonds is realized for the first time; conditions of the preparation method are not severe, purification is easy to carry out, an obtained product has high yield and purity, it is convenient to popularize and apply the method, and the hybrid compound has a potential application value in the fields of medicine, biology, catalysts, surfactants, etc.

Description

technical field [0001] The invention relates to a synthesis technology of an organic-inorganic hybrid macromolecular compound, in particular to a diacetone-D-galactose modified heteropolyacid hybrid and a preparation method thereof. Background technique [0002] Cancer has always been a serious threat to human health. The current environmental pollution is increasing day by day, the living environment of human beings is deteriorating, and the contact with carcinogenic factors is getting closer and closer, resulting in a rapid increase in the mortality rate of human beings caused by cancer. The current treatment methods for cancer generally include surgical treatment, radiotherapy and chemotherapy, but chemotherapy is still the main method at present. Chemotherapy is to bring drugs to the whole body through blood vessels, affecting all cells in the body. This therapy is sometimes called "cytotoxic therapy" because the drugs used are harmful, even toxic, and the cells in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H13/06C07H1/00
Inventor 王维杨海宽杨洁刘波胡敏标
Owner NANKAI UNIV
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