5,5-disubstituted-2-imino-pyrrolidine derivatives, preparation methods and pharmaceutical uses thereof

A technology of substituents and alkyl groups, used in 5,5-disubstituted-2-iminopyrrolidine derivatives, their preparation and their application in medicine, can solve the problem of increased bleeding, influence, weakening, etc. question
CN102471264BInactive Publication Date: 2014-04-02SHANGHAI HENGRUI PHARM CO LTD +2
6 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI HENGRUI PHARM CO LTD
Publication Date
2014-04-02
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

Disclosed are 5,5-disubstituted-2-imino-pyrrolidine derivatives of formula (I) and their pharmaceutically acceptable salts, preparation methods and uses thereof in medicine as thrombin receptor antagonists, wherein each substituents of formula (I) is defined as the description.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to a new 5,5-disubstituted-2-iminopyrrolidine derivative, its preparation method and pharmaceutical composition containing the derivative and its use as a therapeutic agent, especially as a thrombin receptor antagonist the use of. Background technique

[0002] Currently, thrombotic disease is the main cause of high morbidity and mortality of cardiovascular diseases worldwide. Arterial thrombosis can cause a variety of acute symptoms including acute coronary syndrome, ischemic stroke / transient ischemia, and peripheral arterial disease. These symptoms are all caused by the damage of atherosclerotic plaque or the damage of vascular endothelial cells, which induces the formation of arterial thrombosis and occlusion, which leads to insufficient blood supply. Platelets play a very important role in the formation of arterial thrombus. In this pathological process, damage to atherosclerotic plaques or damage to vascular endothe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More