Process of extracting volatile oils and alpinetin from Alpinia katsumadai

A technology of volatile oil and alpinol, which is applied in the field of extracting volatile oil and alpinol, can solve the problems of high extraction loss of effective parts, low extraction rate, and increased activity of pepsin, and achieve the goals of reducing purification steps, easy operation, and reduced dosage Effect

Inactive Publication Date: 2012-05-30
苏州宝泽堂医药科技有限公司
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Problems solved by technology

In 1980, Li Zailiu and others reported that through chronic pharmacological experiments on dogs with a three-way Pavlovian stomach, the extract of cardamom had no obvious effect on the total acid excretion, but it significantly increased the activity of pepsin
[0008] At present, there are few studies on the extraction process of alpinin and cardamom volatile oil. Among them, Wang Xiuqin et al. "Optimization of the extraction process of alpinin and cardamom from cardamom" discloses that the extraction method of alpinin is to use 8 times the amount of 95% Ethanol reflux extraction twice, 2 hours each time, the extraction loss of the effective part of this method is large, and the extraction rate is low

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  • Process of extracting volatile oils and alpinetin from Alpinia katsumadai

Examples

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Effect test

Embodiment 1

[0024] Remove impurities from the cardamom medicinal material, crush it into a coarse powder, take 500g and put it into the extraction kettle, debug the extraction kettle, the extraction temperature is 45°C, the extraction pressure is 18MPa, CO 2 The flow rate is 40L / h, the extraction time is 1.5h, the temperature of the separation tank I is 40°C, the pressure is 6.5MPa, the temperature of the separation tank II is 45°C, and the pressure is 5.5MPa, the extract is analyzed from the separation tank, and the extract is collected. Filter to obtain the volatile oil product, add the above extracted medicinal residues to 0.1L 85% methanol solution, and adjust the extraction parameters: the extraction temperature is 55°C, the extraction pressure is 45MPa, CO 2 The flow rate is 35L / h, the extraction time is 2.5h, the temperature of the separation tank I is 40°C, the pressure is 9MPa, the temperature of the separation tank II is 45°C, the pressure is 6.5Mpa, and the supercritical CO 2 E...

Embodiment 2

[0026] Remove impurities from the cardamom medicinal material, crush it into a coarse powder, take 500g and put it into the extraction kettle, debug the extraction kettle, the extraction temperature is 35°C, the extraction pressure is 25MPa, CO 2 The flow rate is 30L / h, the extraction time is 3h, the temperature of the separation tank I is 30°C, the pressure is 7MPa, the temperature of the separation tank II is 35°C, and the pressure is 6MPa, analyze the extract from the separation tank, collect the extract, and filter to obtain For volatile oil products, add the extracted medicinal residues to 0.1L 90% methanol solution, and adjust the extraction parameters: extraction temperature is 75°C, extraction pressure is 30MPa, CO 2 The flow rate is 25L / h, the extraction time is 5h, the temperature of the separation tank I is 45°C, the pressure is 10MPa, the temperature of the separation tank II is 40°C, the pressure is 5.5Mpa, and the supercritical CO 2 Extraction, collect flavonoids...

Embodiment 3

[0028] Remove impurities from the cardamom medicinal material, crush it into a coarse powder, take 1kg and put it into the extraction kettle, debug the extraction kettle, the extraction temperature is 40°C, the extraction pressure is 20MPa, CO 2 The flow rate is 25L / h, the extraction time is 2.5h, the temperature of the separation tank I is 35°C, and the pressure is 6MPa, the temperature of the separation tank II is 30°C, and the pressure is 5MPa. Analyze the extract from the separation tank, collect the extract, and filter it. To obtain the volatile oil product, add the above-mentioned medicinal residue after extraction to 0.2L95% methanol solution, and adjust the extraction parameters: the extraction temperature is 65°C, the extraction pressure is 35MPa, CO 2 The flow rate is 45L / h, the extraction time is 2h, the temperature of the separation tank I is 40-45 ° C, the pressure is 7 MPa, the temperature of the separation tank II is 35 ° C, the pressure is 5 MPa, and the supercr...

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Abstract

The invention relates to a process of extracting volatile oils and alpinetin from Alpinia katsumadai. The process comprises the following steps of: grinding Alpinia katsumadai material, loading to an extraction kettle; performing supercritical CO2 extraction; filtering to obtain a volatile oil product; mixing the extraction residues with an appropriate amount of entrainers; performing supercritical CO2 extraction again to obtain flavonoids; diluting the flavonoid extract; subjecting to membrane separation; purifying by polyamide column chromatography; eluting with alcohols; concentrating to crystallize the eluate; re-crystallizing with anhydrous methanol; filtering out crystals; and drying to obtain an alpinetin product. The process is simple, has less pollution and low energy consumption, and is better in extraction rate and purity.

Description

technical field [0001] The invention relates to a process for extracting volatile oil and alpinol from cardamom. Background technique [0002] Alpinetin (Alpinetin); [0003] Chemical name: (S)-7-hydroxy-5-methoxyflavone; [0004] Molecular formula: C 16 h 14 o 4 ;Molecular weight: 270.27996; [0005] Molecular formula: [0006] [0007] Cardamom is the dry and nearly mature seed of Alpinia katsumadai Hayata, a plant in the ginger family. It is one of the commonly used aromatizing damp medicines. Food stagnation, choking and nausea, cold-damp vomiting and diarrhea, accumulation of phlegm and fluid, etc. Seeds contain flavonoids such as Alpinetin, Carda-monin and volatile oil compounds. Alpinetin has antibacterial, anti-oxidant, anti-cancer, anti-thrombosis, lowering blood pressure, lowering blood fat, lowering blood sugar, and anti-inflammatory effects. Emesis, analgesia and other effects, grass cardamom decoction excites guinea pig isolated intestines at low conc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B9/02C07D311/30C07D311/40
CPCY02P20/54
Inventor 李法庆刘东锋
Owner 苏州宝泽堂医药科技有限公司
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