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Chinese medicine gel ointment for treating children diarrhea and preparing method thereof

A gel ointment and a technology for infantile diarrhea, which are applied in the field of traditional Chinese medicine compound preparations and their preparation, and can solve the problems of insufficient bioavailability, irritating damage to children's tender skin, poor adhesion and the like

Inactive Publication Date: 2012-07-04
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This dosage form has defects such as inconvenient use, poor adhesion, easy scattering of powdered medicine, easy contamination of clothes, easy drying of ointment, poor quality stability, and insufficient bioavailability, and the amount of medicinal materials is not disclosed in the article, and the amount of each paste is also difficult to control. It is impossible to industrialize mass production
[0004] In the prior art (Chinese invention patents CN1876049A, CN1292770C) respectively disclose two kinds of medicines and preparation methods for treating infantile diarrhea, wherein the raw materials of the medicines are composed of cloves, white pepper, Evodia rutaecarpas, and cinnamon. It is irritating and will cause irritating damage to the tender skin of children

Method used

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  • Chinese medicine gel ointment for treating children diarrhea and preparing method thereof
  • Chinese medicine gel ointment for treating children diarrhea and preparing method thereof
  • Chinese medicine gel ointment for treating children diarrhea and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Preparation of Herbal Mixture for Gel Ointment

[0028] Take by weight Evodia rutaecarpa: Clove: Cinnamon is the ratio of 4: 3: 1 and take 200g of medicinal materials, extract the extract and prepare the Chinese medicine mixture of gel ointment according to the following process:

[0029] A, the mixed medicinal materials are pulverized and passed through a 40 mesh sieve;

[0030] B. Add 2Kg of 75% ethanol to the sieved medicinal material and soak for 1 hour, heat and reflux for extraction for 1 hour, filter to obtain the filtrate, then use 8 times the amount of 75% ethanol to heat and reflux for extraction twice, each time for 1 hour, and combine the extracts three times ;

[0031] C, the extract is reclaimed under reduced pressure to ethanol, and concentrated to a concentrated extract whose relative density is 1.15g / mL;

[0032] D. Get 20g of polyethylene glycol 6000, dissolve it in 15mL of water, then add 50g of the above-mentioned extract, mix well, add 25g of c...

Embodiment 2

[0043] 1. Preparation of Herbal Mixture for Gel Ointment

[0044] Take by weight Evodia rutaecarpa: clove: cinnamon in the ratio of 6: 2: 3 and take 200g of medicinal materials, extract the extract and prepare the Chinese medicine mixture of gel ointment according to the following process:

[0045] A, the mixed medicinal material is pulverized, and crosses 80 mesh sieves;

[0046] B. Add 2Kg of 95% ethanol to the sieved medicinal material, heat and reflux for extraction for 1h, filter to obtain the filtrate, then use 1.6Kg of 95% ethanol for reflux to extract the medicinal residues for 1h, and combine the ethanol extract;

[0047] C, the ethanol extract is concentrated to about 1.20g / mL extract density;

[0048] D. Take 15g of polyethylene glycol 6000, dissolve it in 16mL of water, then take 40g of the above extract, mix well, add 16g of calcium hydrogen phosphate, and mix well to obtain a Chinese medicine mixture.

[0049] 2. Preparation of Gel Ointment Blank Matrix

[005...

Embodiment 3

[0054] 1. Preparation of Herbal Mixture for Gel Ointment

[0055] By weight Evodia rutaecarpa: clove: cinnamon is the ratio of 5: 1: 2 and takes 210g of medicinal materials, extracts the extract and prepares the Chinese medicine mixture of gel ointment according to the following process:

[0056] A, the mixed medicinal material is pulverized, and crosses 80 mesh sieves;

[0057] B. Add 2.1Kg of 95% ethanol to the sieved medicinal material and soak for 1 hour, heat and reflux for extraction for 1 hour, filter to obtain the filtrate, and then use 1.7 Kg of 95% ethanol for reflux extraction of medicinal residues for 1 hour, and combine the ethanol extract;

[0058] C, the ethanol extract is concentrated to about 1.30g / mL extract density;

[0059] D. Take 10g of polyethylene glycol 6000, dissolve it in 6mL of water, then add 40g of the above-mentioned extract, mix well, add 15g of micropowdered silica gel, mix well, and obtain a Chinese medicine mixture.

[0060] 2. Preparation ...

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Abstract

Chinese medicine gel ointment for treating children diarrhea and a preparing method thereof relate to a Chinese medicine compound preparation and a preparation method of the preparation. The gel ointment is prepared by the steps of taking Chinese medicine raw materials of fructus evodiae, syzygium aromaticum and cinnamon with weight ratio of 4-6:1-3:1-3, extracting the Chinese medicine raw materials through 70-95% ethanol solution, concentrating the obtained extraction solution into Chinese medicine extract with relative density of 1.10-1.30, adding an adsorption agent and a dispersing agent into the extract to obtain Chinese medicine mixture, evenly mixing the Chinese medicine mixture and blank matrix according to a weight ratio of 1:3-10 at 50-70 DEG C, and coating the mixture of the Chinese medicine mixture and the blank matrix on a lining material to obtain the gel ointment. The Chinese medicine gel ointment for treating the children diarrhea is improved by animal tests to have the advantages of being good in anti-diarrhea and analgesia effect and safety, large in medicine loading amount, good in permeability, small in skin stimulation, plenty in water containing and the like, and is particularly suitable for being applied to children. In addition, the medicine is easy to absorb.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine gel ointment prepared from a compound traditional Chinese medicine extract for treating diarrhea in children and a preparation method thereof. Background technique [0002] Diarrhea in children is one of the common clinical diseases and frequently-occurring diseases. Among the drugs used by Western medicine for the treatment of diarrhea, antibiotics, antidiarrheals, antispasmodics and sedatives are useful according to the cause of the disease, but these drugs have certain side effects. Therefore, it should be used with caution. Traditional Chinese medicine has accumulated rich experience in the treatment of infantile diarrhea, and combined with the characteristics of infants and young children, a variety of treatment methods have been adopted to achieve better curative effect. There are many cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/754A61K9/06A61K47/34A61K47/38A61K47/40A61K47/42A61P1/12
Inventor 王冬梅徐月红李静陈宝唐志叶卉
Owner SUN YAT SEN UNIV
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