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Compound vitamin lipid nanoparticle and preparation method thereof

A lipid nanoparticle and multivitamin technology, which is applied in the field of carrier systems, can solve the problems of poor stability and low bioavailability, and achieve the effects of good stability, simple preparation method, and convenient preparation

Inactive Publication Date: 2012-07-11
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009]Technical problem: the present invention provides a kind of high stability, good compatibility water-soluble complex vitamin lipid nanoparticle, solves the problem of vitamin A palmitate in the prior art esters, vitamin E acetate and vitamin C ethyl ether have poor stability and low bioavailability

Method used

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  • Compound vitamin lipid nanoparticle and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Preparation of complex vitamin lipid nanoparticles

[0034] Composition formula

[0035]

[0036] The preparation steps of this embodiment are as follows:

[0037] 1. Weigh 1.0 g of polyethylene glycol-8 caprylic capric acid glyceride, 1.0 g of cetearyl glucoside, and 92.5 g of deionized water into a beaker, and heat it in a water bath at 60°C to a homogeneous solution.

[0038] 2. Weigh 2.0 g of acetylated monoglyceride and 0.5 g of caprylic capric acid glyceride and heat in a water bath at 60°C.

[0039] 3. After the lipid in the beaker is completely melted, add 1.0 g of vitamin A and 1.0 g of vitamin E, heat and mix well.

[0040] 4. Add the water phase to the above system, stir evenly, add 1.0 g of vitamin C, and shear. At the same time, turn on the high-pressure homogenizer and preheat it to 60°C with 70°C deionized water.

[0041] 5. Inject the high-temperature emulsion system after uniform shearing into the high-pressure homogenizer, adjust th...

Embodiment 2

[0044] weight Polyethylene Glycol-8 Caprylic Glycerides 4.0g cetearyl glucoside 1.5g Acetylated Monoglycerides 1.5g Glyceryl Caprylate 0.5g Soybean Powder Phospholipids 0.5g Vitamin A 1.5g Vitamin E 3.0g Vitamin C 2.5g Deionized water 85.0g

[0045] Preparation steps:

[0046] 1. Weigh 4.0 g of polyethylene glycol-8 caprylic capric acid glyceride, 1.5 g of cetearyl glucoside, 0.5 g of soybean powder phospholipid, and 85.0 g of deionized water into a beaker, and heat in a water bath at 55°C until homogeneous solution.

[0047] 2. Weigh 1.5 grams of acetylated monoglycerides and 0.5 grams of caprylic capric acid glycerides and heat them in a water bath at 55°C.

[0048] 3. After the lipid in the beaker is completely melted, add 1.5 grams of vitamin A and 3.0 grams of vitamin E, heat and mix well.

[0049] 4. Add the water phase to the above system, stir evenly, add 2.5 grams of vitamin C, and shear. At the ...

Embodiment 3

[0053] weight Cetostearyl Alcohol / Polyethylene Glycol-20 Cetostearyl Alcohol 1.0g Macrogol-100 Stearate 2.0g Glyceryl monostearate 2.0g Acetylated monoglyceride 4.0g olive oil 0.5g Corn oil 0.5g Vitamin A 2.0g Vitamin E 5.0g Vitamin C 4.0g Deionized water 79.0g

[0054] Preparation steps:

[0055] 1. Weigh 1.0 grams of cetostearyl alcohol / polyethylene glycol-20 cetostearyl alcohol, 2.0 grams of polyethylene glycol-100 stearate, and 79.0 grams of deionized water into a beaker for 70 ° C Heat in a water bath until a homogeneous solution is obtained.

[0056] 2. Weigh 2.0 grams of glyceryl monostearate, 4.0 grams of acetylated monoglycerides, 0.5 grams of olive oil, and 0.5 grams of corn oil and heat them in a water bath at 70°C.

[0057] 3. After the lipid in the beaker is completely melted, add 2.0 grams of vitamin A and 5.0 grams of vitamin E, heat and mix well.

[0058] 4. Add the water phase to th...

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Abstract

The invention discloses a compound vitamin lipid nanoparticle. The lipid nanoparticle is loaded with three active ingredients, i.e. vitamin A, vitamin C, vitamin E and is characterized by comprising the following ingredients in percentage by weight: 1-2% of vitamin A, 1-4% of vitamin C, 1-5% of vitamin E, 2-10% of emulsifying agent, 1-12% of compound lipid material and the rest of water, wherein the compound lipid material is a mixture of a solid lipid material and a liquid lipid material; and the lipid materials are selected from at least one or several of glycerol monolaurate, caprylic capric triglyceride, olive oil, soybean oil, corn oil, sunflower seed oil, acetylation monoglyceride, glycerin monostearate and stearic acid. The lipid nanoparticle has good stability, water solubility and repeatability and can be applied to the preparation of daily chemical products and health care foods containing the vitamin A, vitamin C and vitamin E; and a preparation method is simple and controlled.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics and food preparation technology, and relates to a nano-scale carrier and a preparation method thereof, in particular to a carrier with vitamin A palmitate, vitamin E acetate and vitamin C ethyl ether as active ingredients Lipid nanoparticles and preparation methods thereof. Background technique [0002] The meaning of vitamin A (VA) actually includes a class of substances that have the same biological activity as VA. Commonly referred to as VA refers to VA1, also known as retinol (Retinol). VA added in food as a nutritional enhancer is usually vitamin A acetate (VA acetate), also known as retinyl acetate (Retinyl acetate, RC) and VA palmitate (VA Palmitate), also known as retinyl palmitate (Retinyl Palmitate, RP) to achieve. Natural VA is mainly all-trans (all-trans) with a small amount of 13-cis (13-cris). The bioactivity of the degraded isomers, 9-cris and 13-cris isomer...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/92A61K8/86A61K8/85A61K8/60A61K8/55A61K8/39A61K8/14A23L1/302A61Q19/00A23L33/15
Inventor 夏强孔荣
Owner SOUTHEAST UNIV
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