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Compound preparation containing benidipine hydrochloride and atorvastatin calcium and application for compound preparation

A technology of atorvastatin calcium and benidipine hydrochloride, which is applied in the field of biomedicine, can solve the problems of no pharmaceutical preparation standards that meet the dosage of the combination, inaccurate dosage, influence on the curative effect of the drug, etc., so as to enhance the therapeutic effect and improve the curative effect. , the effect of facilitating the promotion and application

Active Publication Date: 2013-08-28
山东新宝医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] When treating hypertension and hyperlipidemia clinically now, there are often the following problems: 1. A single drug is mainly used to treat a disease, but hypertension is accompanied by multiple complications such as hyperlipidemia, so it is necessary to use multiple drugs to ensure the curative effect. Only when the drugs are used at the same time can the therapeutic effect be guaranteed; 2. When the drug is used in combination, because there is no drug preparation standard that meets the combined drug dosage, the clinically used drug dosage is inaccurate, which affects the drug efficacy

Method used

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  • Compound preparation containing benidipine hydrochloride and atorvastatin calcium and application for compound preparation
  • Compound preparation containing benidipine hydrochloride and atorvastatin calcium and application for compound preparation

Examples

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Effect test

Embodiment 1

[0020] 1 part by weight of benidipine hydrochloride, 1 part by weight of atorvastatin calcium, 44 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 40 parts by weight of pregelatinized starch, 15 parts by weight of sodium carboxymethyl starch, hypromellose 2.5 parts by weight of magnesium stearate and 1.5 parts by weight of magnesium stearate.

[0021] The raw materials and auxiliary materials are respectively pulverized through 80-mesh sieves, and the hypromellose is prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, mix other raw and auxiliary materials uniformly by the method of equal incremental dilution, use the prepared adhesive to make a soft material, pass through a 18-mesh sieve for granulation, fully dry at 60°C, and granulate with an 18-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat. Each tablet contains 1 mg of benid...

Embodiment 2

[0023] 1 part by weight of benidipine hydrochloride, 5 parts by weight of atorvastatin calcium, 40 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 45 parts by weight of pregelatinized starch, 15 parts by weight of sodium carboxymethyl starch, croscarmellose 20 parts by weight of sodium cellulose, 2.5 parts by weight of hypromellose, and 1.5 parts by weight of magnesium stearate.

[0024] The raw materials and auxiliary materials were crushed through an 80-mesh sieve, and the povidone K30 was prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, other raw and auxiliary materials are mixed uniformly by the method of equal incremental dilution, and the soft material is made of the prepared adhesive, granulated through a 20-mesh sieve, fully dried at 65°C, and granulated with a 20-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat. Each ...

Embodiment 3

[0026] 2 parts by weight of benidipine hydrochloride, 10 parts by weight of atorvastatin calcium, 30 parts by weight of microcrystalline cellulose, 58 parts by weight of pregelatinized starch, 20 parts by weight of sodium carboxymethyl starch, 3 parts by weight of povidone K30, hard 2 parts by weight of magnesium fatty acid.

[0027] The raw materials and auxiliary materials were crushed through an 80-mesh sieve, and the povidone K30 was prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, other raw and auxiliary materials are mixed uniformly by the method of equal incremental dilution, and the soft material is made of the prepared adhesive, granulated through a 20-mesh sieve, fully dried at 65°C, and granulated with a 20-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat. Each tablet contains benidipine hydrochloride 2 mg and atorvastatin calcium 10 mg.

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Abstract

The invention discloses a compound preparation containing benidipine hydrochloride and atorvastatin calcium and application for the compound preparation. The compound preparation comprises the following active ingredients: the benidipine hydrochloride and the atorvastatin calcium. By the compound preparation, the defect that hypertension and hyperlipidemia cannot be treated simultaneously by single medicines is overcome, and the compound preparation is prepared by compounding the benidipine hydrochloride and the atorvastatin calcium. The preparation can be prepared into oral formulations of different forms, and a treatment effect of the compound preparation is enhanced under the synergetic and complementary action of medicines, the using dose of the medicines is reduced in clinical application, and the adverse reaction of patients is relieved, so the compound preparation is accepted easily by the patients. The compound preparation has an obvious treatment effect on hypertension and hyperlipidemia, is suitable for the patients who suffer from serious cardiovascular cerebrovascular diseases accompanied with high cholesterol, blood fat metabolic disturbance, cardiac failure, atherosclerosis, coronary heart diseases, acute myocardial infarction and the like, and is low in cost, easy to prepare and convenient to popularize and apply.

Description

technical field [0001] The invention relates to a compound preparation and an application thereof, in particular to a compound preparation containing benidipine hydrochloride and atorvastatin calcium and an application thereof, belonging to the technical field of biomedicine. Background technique [0002] Hypertension is the most prevalent disease in the world today, known as the "silent killer". According to the global burden of disease survey in 2000, 50% of cardiovascular diseases are caused by high blood pressure, which accounts for 4.5% of the current global disease burden. High blood pressure is common in both developed and developing countries. According to statistics, in recent years, the prevalence of hypertension among residents over the age of 18 in my country has reached 18.8%, and the number of patients in the country has reached 200 million; while it has risen to 60% to 70% among people over 70 years old. Among the causes of death of people over 40 years old i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4545A61P9/12A61P3/06A61K31/40
Inventor 许东升陈海霞初茂忠杨毅娟徐彦韩丽丽马全龙王浩骅孙山梁海勇
Owner 山东新宝医药有限公司
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