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Traditional Chinese medicine composition for treating glaucoma as well as preparation method and administration mode of same

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine for the treatment of glaucoma, can solve the problems of patients with impaired visual function, optic nerve blindness, visual field defect, etc., and achieve the effect of prevention and treatment of optic nerve damage, no drug resistance, and high cure rate

Inactive Publication Date: 2012-07-18
刘娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High intraocular pressure is the basic factor of visual function damage in glaucoma. If the intraocular pressure cannot be effectively controlled, the apoptosis of retinal photoreceptors and ganglion cells, the extensive damage of axons, and the loss of application fibers will cause severe visual dysfunction, resulting in Vision loss and visual field defect can eventually lead to blindness, but long-term clinical and experimental studies have found that after the intraocular pressure of glaucoma is controlled within the normal range, about one-third of patients with glaucoma continue to have impaired visual function, eventually leading to optic atrophy and death. blindness

Method used

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  • Traditional Chinese medicine composition for treating glaucoma as well as preparation method and administration mode of same
  • Traditional Chinese medicine composition for treating glaucoma as well as preparation method and administration mode of same

Examples

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preparation example Construction

[0054] When the dosage form of the Chinese medicinal composition of the present invention is a granule, its preparation method comprises the following steps:

[0055] The first step is to mix the components according to the stated ratio, add 80% to 90% ethanol with an alcohol concentration of 3 to 5 times that of the mixture, heat to boiling and reflux for 2 to 4 hours, filter, and use the percolation method Slowly percolating at a rate of 1-2ml per minute, collecting the percolating liquid, and then concentrating under reduced pressure under vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C, spray drying, spraying The inlet air temperature of the dryer is 150-170°C, and the outlet air temperature is 75-85°C, and then pulverized into powder to make dry paste powder;

[0056] In the second step, 0.3-0.5 times the mass of sucrose powder and 0.1-0.2 times the mass of the dry paste powder are added to the obtained dry paste powder to prepare granule...

Embodiment 1

[0069] Embodiment 1 The decoction prepared by the traditional Chinese medicine composition of the present invention

[0070] 22g of Tribulus terrestris, 68g of Salvia miltiorrhiza, 48g of Wolfberry, 68g of Chuanxiong, 22g of Pueraria, 33g of ginseng, 12g of Paeonia lactiflora, 9g of Cyperus officinalis, 32g of Radix Scutellariae, 18g of Scutellaria, 18g of Gardenia, 18g of Equisetum, 32g of Paeonia lactiflora, Sanleng 32g, Puhuang 33g, black sesame 48g, Apocynum sackcloth 33g, Cortex Moutan 32g and borneol 9g were mixed, pulverized into powder, the obtained powder was added to 2300g cold water and soaked for 36 hours, and simmered for 2 hours. The decocting liquid was filtered to obtain the first filtrate, the filter residue obtained by filtration was added to 600 g of cold water again, decocted for 2 hours at low heat, filtered to obtain the second filtrate, and the two filtrates were combined to obtain the decoction.

Embodiment 2

[0071] Example 2 Granules prepared from traditional Chinese medicine composition of the present invention

[0072] 22g of Tribulus terrestris, 68g of Salvia miltiorrhiza, 48g of Wolfberry, 68g of Chuanxiong, 22g of Pueraria, 33g of ginseng, 12g of Paeonia lactiflora, 9g of Cyperus officinalis, 32g of Radix Scutellariae, 18g of Scutellaria, 18g of Gardenia, 18g of Equisetum, 32g of Paeonia lactiflora, Sanleng 32g, Puhuang 33g, black sesame 48g, Apocynum sackcloth 33g, Cortex Moutan 32g and borneol 9g were mixed, added 2300g of ethanol with an alcohol concentration of 90%, heated to boiling and refluxed for 3 hours, filtered, and permeated with 1ml per minute. Slowly percolating at a speed, collecting the percolating liquid, and then concentrating under reduced pressure under a vacuum of 0.09Mpa to a paste with a relative density of 1.10 at 60°C, spray drying, the inlet air temperature of the spray dryer is 170°C, and the air outlet temperature is 85°C. ℃, then pulverized into p...

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Abstract

The invention provides a traditional Chinese medicine composition for treating glaucoma, which comprises caltrop, salvia miltiorrhiza, fructus lycii, ligusticum wallichii, radix puerariae, ginseng, radix paeoniae alba, rhizoma cyperi, fructus leonuri, radix scutellariae, gardenia, horsetail, radix paeoniae rubra, rhizoma sparganii, pollen typhae, semen sesami nigrum, folium apocyni veneti, cortexmoutan radicis and borneol. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is small in side effects, good in curative effect, low incost, high in cure rate, free from tolerance, and convenient to take; the traditional Chinese medicine composition can well control postoperative intraocular pressure based on an operative treatment,prevents and treats glaucomatous optic neuropathy, and thus better treats the glaucoma.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical engineering, in particular to a traditional Chinese medicine for treating glaucoma. Background technique [0002] Glaucoma is a multi-factor irreversible blinding eye disease characterized by specific optic atrophy and visual field defect. The World Health Organization has listed glaucoma as the second blinding eye disease. The prevalence of primary glaucoma in the population of 14%, while the incidence of primary glaucoma moderate blindness and low vision were 9.26% and 16.67%, respectively. [0003] The visual function damage of glaucoma patients is mainly due to ischemia and hypoxia caused by high intraocular pressure or low blood perfusion pressure, which interrupt the axoplasmic flow of optic nerve fibers, thereby causing optic nerve damage. High intraocular pressure is the basic factor of glaucoma visual function damage. If intraocular pressure cannot be effectively controlled, retin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/902A61K9/08A61K9/16A61P27/06A61K31/045
Inventor 刘娟王子熹姜永华
Owner 刘娟
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