Granule for treating hypertension

A technology for granules and hypertension, applied in the field of granules for the treatment of hypertension, to achieve the effects of small side effects, good absorption and strong synergistic effect

Inactive Publication Date: 2012-07-18
北京水圣木科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Application number: 200810159766.9, the name of the invention is "A Zhedipine Composition", the patent application for the invention discloses "A Zhedipine and β-cyclodextrin dosage is 3-15 times of Azhedipine in terms of weight ratio... ", its "...the bioavailability of the azedipine composition can reach 42.2%", but the invention pate

Method used

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  • Granule for treating hypertension
  • Granule for treating hypertension
  • Granule for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The granules of the present embodiment are prepared from the following components by weight percentage:

[0039] Isradipine 0.1%, Labetalol 3%, Tetragalus 10% and including 86.9% lactose, sucrose, xylitol, chitosan, sodium carboxymethylcellulose, polyvinylpyrrolidone, hydroxypropylcellulose, methyl Pharmaceutical carriers including cellulose, glycerol and ethanol.

[0040] Among them, the effective average particle diameter of isradipine, labetalol, fangji and pharmaceutical carrier after pulverization is 1500nm.

Embodiment 2

[0042] The granules of the present embodiment are prepared from the following components by weight percentage:

[0043] Isradipine 60%, labetalol 15%, fangji 20% and 5% include bifidosaccharide, starch, mannitol, microcrystalline cellulose, methyl cellulose, ethyl cellulose, glycerin, sorbitol and ethanol in pharmaceutical carrier in it.

[0044] Among them, the raw materials: isradipine, labetalol, fangji and medicinal carrier, and the effective average particle size after pulverization is 1000nm.

Embodiment 3

[0046] The granules of the present embodiment are prepared from the following components by weight percentage:

[0047] Isradipine 11%, Labetalol 5%, Fangji 14% and 70% including mannitol, microcrystalline cellulose, dextrin, xylitol, chitosan, bifidosaccharide, starch, mannitol, microcrystalline cellulose Pharmaceutical carriers including sodium carboxymethylcellulose, glycerol and ethanol.

[0048] Among them, the raw materials: isradipine, labetalol, fangji and medicinal carrier, and the effective average particle size after pulverization is 1200nm.

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PUM

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Abstract

The invention relates to a granule for treating hypertension. The granule is characterized by comprising a calcium channel blocker, a beta receptor inhibitor, Chinese medicinal herbs and a medicinal carrier, and is prepared from the following components in percentage by weight: 0.1-60 percent of isradipine, 3-15 percent of labetalol, 10-20 percent of yellowmouth dutchmanspipe root and 7-70 percent of the medicinal carrier. The granule has the advantages of high safety, high synergistic effect among raw material components, high bioavailability, and capability of effectively reducing the side effects of separate azelnidipine on the health of a patient.

Description

[technical field] [0001] The invention relates to medicine, in particular to a granule for treating hypertension. [Background technique] [0002] Hypertension is a kind of common disease, frequently-occurring disease, and it occurs in emotion will disorder, eating and drinking is discordant, and internal injury is weak and weak relevant. The World Health Organization (WHO) stipulates the adult hypertension standard: systolic blood pressure ≤ 18.7KPa (140mmHg), diastolic blood pressure ≤ 12.0KPa (90mmHg) is normal blood pressure; systolic blood pressure ≥ 21.3KPa (160mmHg) or diastolic blood pressure ≥ 12.7KPa (95mmHg) for high blood pressure. Currently, there are traditional Chinese medicines and western medicines used for the treatment of high blood pressure, and traditional Chinese medicines alone are often slow to take effect, and western medicines alone are more harmful to the body. Patients only choose to take western medicines when they have to. Therefore, it is neces...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K36/59A61K9/16A61P9/12A61K31/4439A61K31/609
Inventor 徐震
Owner 北京水圣木科技有限责任公司
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