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Method for preparing unsaturated fatty acid plant sterol ester using alpha-linolenic acid as main component

A technology of unsaturated fatty acid and phytosterol ester, which is applied in the direction of fatty acid esterification, preparation of steroids, chemical instruments and methods, etc. It can solve the problems of low activity and poor solubility of free phytosterols, and achieve simple preparation methods and cancer inhibition Occurrence and transfer, medicinal and health function improvement effects

Inactive Publication Date: 2012-07-18
西安蓝天生物工程有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The unsaturated fatty acid phytosterol ester mainly composed of α-linolenic acid prepared by the method effectively combines phytosterols with α-linolenic acid, which can not only overcome the problems of poor solubility and low activity of free phytosterols in water and oil, but also It also has the active ingredient of α-linolenic acid, which has strong medicinal and health functions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step 1. Preparation of unsaturated fatty acid methyl esters mainly based on α-linolenic acid: using a reactor equipped with a condensing reflux device, adding linseed oil, methanol and catalyst sodium methoxide to the reactor, at a temperature of 65 ° C Under the conditions of alcoholysis reaction for 5 hours, during the alcoholysis reaction, the condensing reflux device will condense the volatilized lower aliphatic alcohol and return it to the reaction system; the product of the alcoholysis reaction is washed with water at a temperature of 50°C, then left to separate the water, and washed repeatedly And stand still to divide the water until the washing liquid is neutral, distill off the remaining water in the washed product, and then heat the distilled product to 70°C under the condition of a pressure not greater than 5000Pa and keep it warm until there are no air bubbles in the product Generate, continue to heat to 150 ℃, distill to obtain unsaturated fatty acid methyl...

Embodiment 2

[0042] Step 1. Preparation of unsaturated fatty acid methyl esters mainly based on α-linolenic acid: using a reactor equipped with a condensing reflux device, adding linseed oil, ethanol and catalyst sodium ethylate to the reactor, at a temperature of 75 ° C Under the conditions of alcoholysis reaction for 2 hours, during the alcoholysis reaction, the condensing reflux device will condense the volatilized lower aliphatic alcohol and return it to the reaction system; the product of the alcoholysis reaction is washed with water at a temperature of 80°C, and the water is separated, and the washing is repeated And stand still to divide the water until the washing liquid is neutral, distill off the remaining water in the washed product, and then heat the distilled product to 150°C under the condition of a pressure not greater than 5000Pa and keep it warm until there are no air bubbles in the product Generate, continue to heat to 210 ℃, distill and obtain unsaturated fatty acid methy...

Embodiment 3

[0054] Step 1. Preparation of unsaturated fatty acid methyl esters mainly based on α-linolenic acid: using a reactor equipped with a condensation reflux device, adding linseed oil, methanol and catalyst sodium methoxide to the reactor, at a temperature of 70 ° C Under the conditions of alcoholysis reaction for 4 hours, the condensing and reflux device will condense the volatilized lower aliphatic alcohol back into the reaction system during the alcoholysis reaction; wash the product of the alcoholysis reaction with water at a temperature of 65°C, let it stand to separate the water, and repeat the washing And stand still to divide the water until the washing liquid is neutral, distill off the remaining water in the washed product, and then heat the distilled product to 100°C under the condition of a pressure not greater than 5000Pa and keep it warm until there are no bubbles in the product Generate, continue to heat to 180 ℃, distill and obtain unsaturated fatty acid methyl este...

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Abstract

The invention discloses a method for preparing an unsaturated fatty acid plant sterol ester using alpha-linolenic acid as a main component. The method comprises the following steps of: 1, performing alcoholysis reaction by using linseed oil and lower fatty alcohol as raw materials to prepare an unsaturated fatty acid methyl ester and a methyl stearate which use alpha-linolenic acid as main components; 2, performing ester exchange reaction by using a plant sterol ester and the unsaturated fatty acid methyl ester and the methyl stearate which use the alpha-linolenic acid as the main components as raw materials to prepare crude unsaturated fatty acid plant sterol ester; and 3, adding activated clay into the crude unsaturated fatty acid plant sterol ester, reacting with stirring, filtering, then collecting filtrate, extracting, separating the lower oil layer, adding methanol for washing, drying, and thus obtaining the unsaturated fatty acid plant sterol ester using the alpha-linolenic acid as the main component. The unsaturated fatty acid plant sterol ester can solve the problems of poor dissolution in water and grease and low activity of free plant sterol esters, has active ingredients of the alpha-linolenic acid, and has strong medicinal and health-care functions.

Description

technical field [0001] The invention belongs to the technical field of preparation of phytosterol esters, and in particular relates to a preparation method of unsaturated fatty acid phytosterol esters mainly composed of α-linolenic acid. Background technique [0002] Phytosterols are ubiquitously present in soybean oil, rapeseed oil, sunflower oil and tallow oil, and can be divided into campesterol, brassicasterol, stigmasterol and β-sitosterol according to the side chain groups in their structural formulas. Phytosterols have a strong anti-inflammatory effect on the human body. It can inhibit the body's absorption of harmful low-density cholesterol, and at the same time ensure the amount of beneficial high-density cholesterol necessary for the human body, thus reducing coronary atherosclerosis and other heart diseases. incidence of disease. However, the solubility of free phytosterols in water and oil is not large, and their biological activity is small, which greatly reduc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J75/00C07J9/00C11C3/10
Inventor 于佑世强军锋王哲军黄伟强马芳
Owner 西安蓝天生物工程有限责任公司
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