Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing

A wound healing and wound dressing technology, which is applied in the field of medical dressings with the functions of cooling and promoting wound healing and the preparation thereof, and achieves the effects of facilitating absorption and retention, controlling wound microcirculation, and preventing the invasion of external bacteria.

Active Publication Date: 2012-07-25
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the dressings related to cold therapy use water and ice packs as cooling substances. There are patents that combine cooling and drug delivery to prepare an eye patch with cooling and drug delivery effects. The edge of the cooling part and the drug delivery part are bonded with industrial glue. But the eye patch can only reduce the temperature of the eye, and its function is similar to that of an ice pack

Method used

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  • Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing
  • Medical dressing with cooling function and wound healing prompting function and preparation method of medical dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Dissolve 8g of polyacrylic acid in deionized water to prepare a polyacrylic acid hydrogel with a mass concentration of 8%; the polyacrylic acid hydrogel is coated with a grammage of 10g / m 2 On the polylactic acid spunlace nonwoven support layer, the hydrogel has a grammage of 80 g / m 2 ; The polylactic acid nanofiber layer loaded with 20% (wt.) norfloxacin prepared by electrospinning is covered on the surface of polyacrylic acid hydrogel, and fixed with polylactic acid perforated non-woven fabric to obtain a cooling and cooling effect. Medical dressings that promote wound healing. The weight of the perforated non-woven layer is 10 g / m 2 , with circular holes with an average pore diameter of 0.8mm; the fiber diameter of the nanofiber layer is 50~200nm, and the gram weight is 0.2~0.4g / m 2 .

[0030] Such as figure 1 As shown, the wound dressing of the present invention includes a perforated non-woven fabric layer 1, a nanofiber layer 2, a hydrogel layer 3 and a support...

Embodiment 2

[0033] Dissolve 6g of sodium alginate in deionized water to prepare an aqueous solution of sodium alginate with a mass concentration of 6%, add 5% (wt.) calcium chloride solution and stir rapidly to form calcium sodium alginate gel; Gel drawdown at a grammage of 60 g / m 2 The surface of the thermoplastic elastomer Vistamaxx spunbonded non-woven support layer is obtained to obtain a double-layer composite of the hydrogel layer and the support layer; The surface of the sugar gel layer; fixed with a polypropylene perforated non-woven fabric to obtain a medical dressing with the effects of cooling down and promoting wound healing. The nanofiber layer has a grammage of 1.0 g / m 2， , the fiber diameter is 200~700nm; the perforated non-woven fabric layer has cross-shaped holes with a diameter of 0.5mm, and the weight is 15 g / m 2， ;The weight of the support layer is 30 g / m 2 .

[0034] The wound dressing keeps the wound temperature at 14-25°C.

Embodiment 3

[0036]Prepare a chitosan solution with a mass concentration of 10%, add 25% (wt.) glutaraldehyde solution to the solution at a mass fraction of 1.2%, stir and disperse quickly to partially cross-link chitosan to obtain a chitosan gel; Chitosan gel is coated on the surface of the support layer made of polypropylene terephthalate fabric by spin coating to obtain a double-layer composite of the hydrogel layer and the support layer. The support layer has a gram weight of 60 g / m 2 ; With 10% gelatin aqueous solution as raw material, the gelatin nanofiber layer loaded with norfloxacin was prepared by microphase separation method, and it was transferred to the surface of the chitosan gel layer of the double-layer composite; with polylactic acid A perforated nonwoven layer anchors the bilayer composite and the nanofiber layer, resulting in a medical dressing with cooling and wound-healing properties. The polylactic acid perforated non-woven fabric has a grammage of 30 g / m 2 , the hol...

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Abstract

The invention discloses a medical dressing with a cooling function and a wound healing promoting function, which at least comprises a perforated non-woven fabric layer, a nanometer fiber layer with a gradient structure, a hydrogel layer and a supporting layer. The preparation method of the medical dressing includes steps of covering hydrogel onto the supporting layer; covering the nanometer fiberlayer with the gradient structure on the hydrogel; and finally reinforcing the perforated non-woven fabric layer on the surface of the nanometer fiber layer so as to obtain the medical dressing. The nanometer fiber layer has the gradient structure, and facilitates absorption and retention of liquid of wound, and medicine can reach the surface of the wound after being released, so that wound healing is promoted; the perforated non-woven fabric layer has a physical isolating effect, avoids outside bacteria, can absorb effusion of the wound, can be easily removed from the surface of the wound and is not adhered with the wound; and the hydrogel layer can realize temperature regulation and reduces the temperature of the wound. The medical dressing comprehensively utilizes a medicine loading performance of nanometer fibers and capillary mobility of liquid, and promotes wound healing while cooling.

Description

technical field [0001] The invention belongs to the field of functional medical dressings, in particular to a medical dressing capable of cooling down and promoting wound healing and a preparation method thereof. Background technique [0002] Wound healing is an extremely complex physiological process. The physical fitness of the patient is the internal factor that determines wound healing, but the role of medical dressings cannot be ignored. Medical dressings are a very important class of medical textiles. With the advancement of science and technology and various needs in the medical field, new types of medical dressings with certain functions have attracted more and more attention. Functional medical dressings can provide special functions for wound healing according to the actual situation of the wound. Generally speaking, medical dressings should include the following functions: (1) Provide a physical barrier for the wound to prevent wound exudate from contaminating o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/32A61L15/28A61L15/26A61L15/24A61L15/44
Inventor 严玉蓉赵静宜邱志明洪舒寒
Owner SOUTH CHINA UNIV OF TECH
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