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Active bone repair material and preparation method thereof

A technology for bone repair and activity, applied in medical science, prostheses, etc., can solve the problem of unstable biological activity

Inactive Publication Date: 2012-07-25
北京博恩康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological activity of natural BMP-2 cannot be stably exerted after being combined with materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Step 1: Put 1g of α-CSH powder into absolute ethanol at a solid-to-liquid ratio of 0.1g / ml, and stir thoroughly to disperse the α-CSH powder in absolute ethanol to prepare α-CSH—anhydrous Ethanol suspension A;

[0023] Step 2: Pour 1g of β-TCP particles into Suspension A and stir again for 20 minutes, and mix thoroughly to obtain Suspension B;

[0024] Step 3: Put the suspension B in a 37°C electric ventilation drying oven, let the absolute ethanol volatilize naturally, and dry it to a constant weight to prepare granular β-TCP / α-CSH composite artificial bone particles C.

[0025] Step 4: Mix the composite artificial bone particles C and distilled water respectively according to the solid-to-liquid ratio of 10g:1ml and then solidify to obtain the solid absorbable artificial bone D, which is then sterilized by irradiation with Co60.

[0026] Step 5: Dissolve 0.1 g of BMP-2 active polypeptide in 5 ml of double-distilled water under sterile conditions, soak the sterilized ...

Embodiment 2

[0028] Step 1: Put 1g of α-CSH powder into absolute ethanol at a solid-to-liquid ratio of 0.1g / ml, and stir thoroughly to disperse the α-CSH powder in absolute ethanol to prepare α-CSH—anhydrous Ethanol suspension A;

[0029] Step 2: Pour 1g of hydroxyapatite particles into the suspension A and fully stir again for 20 minutes, and fully mix to obtain the suspension B;

[0030] Step 3: Put the suspension B in a 37°C electric ventilation drying oven, let the absolute ethanol volatilize naturally, and dry to constant weight to prepare granular hydroxyapatite / α-CSH composite artificial bone particles C.

[0031] Step 4: Mix the composite artificial bone particles C and deionized water respectively according to the solid-to-liquid ratio of 10g:1ml, and then solidify to obtain solid absorbable artificial bone D, which is then sterilized by Co60 irradiation.

[0032] Step 5: Dissolve 50 mg of BMP-2 active polypeptide in 5 ml of double-distilled water under sterile conditions, soak t...

Embodiment 3

[0034] Step 1: Put 1g of α-CSH powder into absolute ethanol according to the solid-to-liquid ratio of 0.3g / ml, and stir thoroughly to disperse the α-CSH powder in absolute ethanol to prepare α-CSH—anhydrous Ethanol suspension A;

[0035] Step 2: Pour the β-TCP particles into suspension A and stir again for 20 minutes, and mix thoroughly to obtain suspension B;

[0036] Step 3: Put the suspension B in a 37°C electric ventilation drying oven, let the absolute ethanol volatilize naturally, and dry it to a constant weight to prepare granular β-TCP / α-CSH composite artificial bone particles C.

[0037] Step 4: Mix the composite artificial bone particles C and 2wt% citric acid solution respectively according to the solid-to-liquid ratio of 5g:1ml and then solidify to obtain solid absorbable artificial bone D, which is sterilized by irradiation with Co60.

[0038] Step 5: Dissolve 5 mg of BMP-2 active polypeptide in 1 ml of double-distilled water under sterile conditions, soak the st...

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Abstract

The invention provides an active bone repair material and a preparation method thereof. The material comprises a solid-state bone repair material matrix and BMP (bone morphogenetic proteins)-2 active peptide, wherein the solid-state bone repair material matrix is a product obtained after mixing a mixture of alpha calcium sulfate hemihydrate (alpha-CSH) and beta tertiary calcium phosphate (beta-TCP) with a curing liquid; and the weight ratio of alpha-CSH to beta-TCP to the curing liquid is (1-100):(1-100):1. The preparation method is simple in formula and the preparation process is practical; and the material is simple to prepare, has good biocompatibility, has the characteristics of low temperature, low vacuum, low energy consumption and low pollution, and conforms to the requirement of synthesizing the material by way of soft processing.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an injectable and absorbable bone repair material with simple preparation, good biocompatibility and remarkable effect and a preparation method thereof. Background technique [0002] Bone defect has always been a difficult problem in orthopedics. In recent years, with the development of minimally invasive surgery, injectable bone substitute (IBS) has attracted more and more attention from scholars from all over the world, and has become one of the research hotspots of biomaterials today. Injectable calcium sulfate bone substitute and calcium phosphate bone substitute are the most commonly used calcium-phosphorus system materials, which are easy to operate and have good biocompatibility. They can be injected into bone defects and solidified in situ to adapt to bone defects for shaping . But both have shortcomings. The absorption of injectable calcium sul...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/54A61L27/12A61L27/02
Inventor 甘少磊
Owner 北京博恩康生物科技有限公司
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