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Method for hydro-thermal preparation of hydroxyapatite powder by calcium silicate precursor

A technology of hydroxyapatite and calcium silicate, used in chemical instruments and methods, prostheses, phosphorus compounds, etc., can solve the problems of HAp powder morphology and chemical composition that are rarely reported.

Active Publication Date: 2012-08-01
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simultaneous preparation and regulation of the morphology and chemical composition of HAp powders are rarely reported

Method used

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  • Method for hydro-thermal preparation of hydroxyapatite powder by calcium silicate precursor
  • Method for hydro-thermal preparation of hydroxyapatite powder by calcium silicate precursor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prepare 0.5mol / L calcium nitrate (Ca(NO 3 ) 2 4H 2 O) and sodium silicate (Na 2 SiO 3 9H 2 O) Aqueous solution. An equal volume of calcium nitrate aqueous solution was added dropwise to the sodium silicate aqueous solution with stirring. After the dropwise addition was complete, stirring was continued for 24 hours. After that, filter, wash and dry to obtain calcium silicate hydrate powder.

[0032] The prepared calcium silicate hydrate powder 1g and 85mL concentration are 0.2mol / L Na 3 PO 4 Mix the aqueous solution (the molar ratio of calcium to phosphorus is about 0.4), transfer to a 100mL reactor after mixing, and conduct hydrothermal treatment at 180°C for 24 hours. After the hydrothermal reaction, filter and wash to obtain the product. The X-ray diffraction pattern confirms that the product is pure hydroxyapatite powder (such as figure 1 Shown in S1); Scanning electron microscopy shows that the product is a nanoparticle, and the particle size is about 90 ...

Embodiment 2

[0034] The calcium silicate hydrate powder prepared in Example 1 was calcined at 800° C. for 2 hours to obtain calcium silicate powder. Mix 1 gram of calcined calcium silicate powder with 85 mL of 0.2 mol / L Na 3 PO 4 The aqueous solutions were mixed (the molar ratio of calcium to phosphorus was about 0.5), and after mixing, they were transferred to a 100mL reactor, and hydrothermally treated at 180°C for 24 hours. After the hydrothermal reaction, filter and wash to obtain the product. The X-ray diffraction pattern confirms that the product is pure hydroxyapatite powder (such as figure 1 Shown in S2); scanning electron microscopy shows that the product is a nanowire with a diameter of about 100 nanometers and a length of 2 microns (such as figure 2 shown in B). Chemical composition analysis showed that the mass percent contents of Na and Si in hydroxyapatite powder were 1.58% and 0.89%, respectively. It shows that the prepared product is hydroxyapatite powder doped with N...

Embodiment 3

[0036] The calcium silicate hydrate powder prepared in Example 1 was calcined at 800° C. for 2 hours to obtain calcium silicate powder. Mix 1 gram of calcined calcium silicate powder with 85 mL of NaH with a concentration of 0.2 mol / L 2 PO 4 The aqueous solutions were mixed (the molar ratio of calcium to phosphorus was about 0.5), and after mixing, they were transferred to a 100mL reactor, and hydrothermally treated at 180°C for 24 hours. After the hydrothermal reaction, filter and wash to obtain the product. The X-ray diffraction pattern confirms that the product is pure hydroxyapatite powder (such as figure 1 Shown in S3); Scanning electron microscopy shows that the product is a nanosheet, the thickness of the nanosheet is about 100 nanometers, the width is about 1-2 microns, and the length can reach 20 microns (such as figure 2 C shown). Chemical composition analysis showed that the mass percent contents of Na and Si in hydroxyapatite powder were 1.47% and 0.94%, respe...

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Abstract

The invention relates to a method for hydro-thermal preparation of hydroxyapatite powder by a calcium silicate precursor, which belongs to the biology medical material field. According to the invention, one of more of a calcium silicate hydrate, or a calcium silicate compound, or a calcium silicate compound doped elements-containing can be taken as a calcium silicate precursor solid, a calcium silicate precursor solid is mixed with an aqueous solution of soluble phosphate with concentration of 0.01-2.5mol / L, calcium and phosphor are mixed according to a mol ratio of 0.03-2.0 and then subjected to a hydro-thermal reaction to obtain the hydroxyapatite powder. The preparation method of the present invention has the advantages of easy operation, low cost, environment-friendly technology route, convenient popularization and the like, the hydroxyapatite powder with various morphologies and different chemical compositions can be obtained, and can be used for the aspects of hard tissue repairing materials, chromatogram separating reagents, drug carriers, high-molecular mechanical reinforcement materials and the like.

Description

technical field [0001] The invention relates to a method for hydrothermally preparing hydroxyapatite powder from a calcium silicate precursor, which belongs to the field of biomedical materials. Background technique [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , HAp] are widely used in biomedical materials, chemical engineering, gas sensors, catalysts, and environmental engineering and other fields. These application fields of HAp depend to a large extent on the morphology of the material. Such as linear or sheet-like HAp has good mechanical properties, can be used to strengthen the mechanical reinforcement components of composite biomaterials (J.Am.Ceram.Soc.2007,90,3694.; Nature 2004,431,287.; Mater . Sci. Eng. C 2009, 29, 2133.). [0003] However, hydroxyapatite (HAp), an inorganic mineral in the human body's natural bones or teeth, also contains carbonate ( ), sodium (Na), magnesium (Mg), strontium (Sr), silicon (Si), potassium (K), zinc (Zn), chlorine (Cl) an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00B01J20/281C08K3/32A61L27/02A61K47/02
Inventor 常江林开利金晓刚
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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